HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Related articles in The JI Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Campos-Martín, Y. Articles by Martínez-Naves, E. Search for Related Content PubMed PubMed Citation Articles by Campos-Martín, Y. Articles by Martínez-Naves, E.

Immature Human Dendritic Cells Infected with Leishmania infantum Are Resistant to NK-Mediated Cytolysis but Are Efficiently Recognized by NKT Cells¹

Yolanda Campos-Martín^*, María Colmenares, Beatriz Gozalbo-López^*, Marta López-Núñez^*, Paul B. Savage and Eduardo Martínez-Naves^2,*

^* Unidad de Inmunología, Facultad de Medicina, Universidad Complutense, Madrid, Spain; Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain; and Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602

Dendritic cells (DC) play an important role in innate and adaptive immunity, interacting with T cells, NK, and NKT cells. A critical step in the interaction of the parasitic protozoa Leishmania with their host is the evasion of both innate and adaptive immunity, producing a long-lasting chronic infection. There is growing evidence that these parasites can modify the Ag-presenting and immunoregulatory functions of DCs. The cells and mechanisms involved in innate immune response against Leishmania are still poorly understood. In this study, we investigated how Leishmania infantum infection affects DC interactions with NK and invariant NKT (iNKTs) cells in humans. We found that infected immature DCs (iDCs) do not up-regulate HLA class I molecules. Despite this, iDCs become resistant to killing mediated by autologous NK cells due to the up-regulation of HLA-E expression, which protects target cells from NK-mediated lysis through interaction with the inhibitory receptor CD94/NKG2A. Furthermore, iDCs infected with L. infantum up-regulate CD1d cell surface expression and consequently can be efficiently recognized and killed by iNKT cells that produce IFN-. These data suggest that L. infantum could be able to evade NK recognition; in contrast, iNKTs may play an important role in the immune response against Leishmania.

Related articles in The JI:

IN THIS ISSUE

The JI 2006 176: 5699-5700. [Full Text]  

This article has been cited by other articles:

				M. X. H. Sanabria, D. A. Vargas-Inchaustegui, L. Xin, and L. Soong Role of Natural Killer Cells in Modulating Dendritic Cell Responses to Leishmania amazonensis Infection Infect. Immun., November 1, 2008; 76(11): 5100 - 5109. [Abstract] [Full Text] [PDF]

				C. Wiethe, A. Debus, M. Mohrs, A. Steinkasserer, M. Lutz, and A. Gessner Dendritic Cell Differentiation State and Their Interaction with NKT Cells Determine Th1/Th2 Differentiation in the Murine Model of Leishmania major Infection J. Immunol., April 1, 2008; 180(7): 4371 - 4381. [Abstract] [Full Text] [PDF]