| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
IIb
3 Induces the Adhesion and Activation of Mast Cells through Interaction with Fibrinogen1
* Division of Cellular Therapy and Division of Hematopoietic Factors, Advanced Clinical Research Center, and
Laboratory of Stem Cell Therapy, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan;
National Institute of Vegetable and Tea Science, National Agriculture Research Organization, Shizuoka, Japan; and
Department of Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
Integrin 
IIb, a well-known marker of megakaryocyte-platelet lineage, has been recently recognized on hemopoietic progenitors. We now demonstrate that integrin IIb
3 is highly expressed on mouse and human mast cells including mouse bone marrow-derived mast cells, peritoneal mast cells, and human cord blood-derived mast cells, and that its binding to extracellular matrix proteins leads to enhancement of biological functions of mast cells in concert with various stimuli. With exposure to various stimuli, including cross-linking of Fc
RI and stem cell factor, mast cells adhered to extracellular matrix proteins such as fibrinogen and von Willebrand factor in an integrin IIb3-dependent manner. In addition, the binding of mast cells to fibrinogen enhanced proliferation, cytokine production, and migration and induced uptake of soluble fibrinogen in response to stem cell factor stimulation, implicating integrin IIb3 in a variety of mast cell functions. In conclusion, mouse and human mast cells express functional integrin IIb3.
This article has been cited by other articles:
|
|
 |
|
  T. Oki, K. Eto, K. Izawa, Y. Yamanishi, N. Inagaki, J. Frampton, T. Kitamura, and J. Kitaura Evidence That Integrin {alpha}IIb{beta}3-dependent Interaction of Mast Cells with Fibrinogen Exacerbates Chronic Inflammation J. Biol. Chem., November 6, 2009; 284(45): 31463 - 31472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Watanabe, T. Satoh, Y. Yamamoto, Y. Kanai, H. Karasuyama, and H. Yokozeki Overproduction of IgE Induces Macrophage-Derived Chemokine (CCL22) Secretion from Basophils J. Immunol., October 15, 2008; 181(8): 5653 - 5659. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yamanishi, J. Kitaura, K. Izawa, T. Matsuoka, T. Oki, Y. Lu, F. Shibata, S. Yamazaki, H. Kumagai, H. Nakajima, et al. Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells Blood, January 15, 2008; 111(2): 688 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Izawa, J. Kitaura, Y. Yamanishi, T. Matsuoka, T. Oki, F. Shibata, H. Kumagai, H. Nakajima, M. Maeda-Yamamoto, J. P. Hauchins, et al. Functional Analysis of Activating Receptor LMIR4 as a Counterpart of Inhibitory Receptor LMIR3 J. Biol. Chem., June 22, 2007; 282(25): 17997 - 18008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Leveille, M. Bouillon, W. Guo, J. Bolduc, E. Sharif-Askari, Y. El-Fakhry, C. Reyes-Moreno, R. Lapointe, Y. Merhi, J. A. Wilkins, et al. CD40 Ligand Binds to {alpha}5beta1 Integrin and Triggers Cell Signaling J. Biol. Chem., February 23, 2007; 282(8): 5143 - 5151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. von Hundelshausen and C. Weber Platelets as Immune Cells: Bridging Inflammation and Cardiovascular Disease Circ. Res., January 5, 2007; 100(1): 27 - 40. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
