| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Guy-Bernier Research Center, Maisonneuve-Rosemont Hospital and Department of Medicine, University of Montreal, Montreal, Quebec, Canada
Identification of the mechanisms underlying the survival of effector T cells and their differentiation into memory T lymphocytes are critically important to understanding memory development. Because cytokines regulate proliferation, differentiation, and survival of T lymphocytes, we hypothesized that cytokine signaling dictates the fate of effector T cells. To follow cytokine receptor expression during T cell responses, we transferred murine TCR transgenic T cells into naive recipients followed by immunization with peptide emulsified in adjuvant or pulsed on dendritic cells. Our findings did not correlate IL-7R 
-chain and IL-2R 
-chain expression on effector CD8+ cells with the generation of memory T lymphocytes. However, we could correlate the extent of IL-7R expression down-regulation on effector T cells with the level of inflammation generated by the immunization. Furthermore, our findings showed that the maintenance of a high level of IL-7R expression by effector T cells at the peak of the response does not preclude their death. This suggests that maintenance of IL-7R expression is not sufficient to prevent T cell contraction. Thus, our results indicate that expression of the IL-7R is not always a good marker for identifying precursors of memory T cells among effectors and that selective expression of the IL-7R by effector T cells should not be used to predict the success of vaccination.
This article has been cited by other articles:
|
|
 |
|
  S. Colombetti, F. Levy, and L. Chapatte IL-7 adjuvant treatment enhances long-term tumor antigen-specific CD8+ T-cell responses after immunization with recombinant lentivector Blood, June 25, 2009; 113(26): 6629 - 6637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Quigley, J. Martinez, X. Huang, and Y. Yang A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection Blood, March 5, 2009; 113(10): 2256 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Crawley, T. Katz, K. Parato, and J. B. Angel IL-2 receptor {gamma} chain cytokines differentially regulate human CD8+CD127+ and CD8+CD127- T cell division and susceptibility to apoptosis Int. Immunol., January 1, 2009; 21(1): 29 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Leignadier, M.-P. Hardy, M. Cloutier, J. Rooney, and N. Labrecque Memory T-lymphocyte survival does not require T-cell receptor expression PNAS, December 23, 2008; 105(51): 20440 - 20445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Shaw and M. N. Starnbach Antigen Delivered by Anthrax Lethal Toxin Induces the Development of Memory CD8+ T Cells That Can Be Rapidly Boosted and Display Effector Functions Infect. Immun., March 1, 2008; 76(3): 1214 - 1222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Haring, X. Jing, J. Bollenbacher-Reilley, H.-H. Xue, W. J. Leonard, and J. T. Harty Constitutive Expression of IL-7 Receptor {alpha} Does Not Support Increased Expansion or Prevent Contraction of Antigen-Specific CD4 or CD8 T Cells following Listeria monocytogenes Infection J. Immunol., March 1, 2008; 180(5): 2855 - 2862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Hammerbeck and M. F. Mescher Antigen Controls IL-7R{alpha} Expression Levels on CD8 T Cells during Full Activation or Tolerance Induction J. Immunol., February 15, 2008; 180(4): 2107 - 2116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Joshi and S. M. Kaech Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation J. Immunol., February 1, 2008; 180(3): 1309 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-H. Hovav, M. W. Panas, S. Rahman, P. Sircar, G. Gillard, M. J. Cayabyab, and N. L. Letvin Duration of Antigen Expression In Vivo following DNA Immunization Modifies the Magnitude, Contraction, and Secondary Responses of CD8+ T Lymphocytes J. Immunol., November 15, 2007; 179(10): 6725 - 6733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Quigley, X. Huang, and Y. Yang Extent of Stimulation Controls the Formation of Memory CD8 T Cells J. Immunol., November 1, 2007; 179(9): 5768 - 5777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Blair and L. Lefrancois Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells PNAS, September 18, 2007; 104(38): 15045 - 15050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Hand, M. Morre, and S. M. Kaech Expression of IL-7 receptor {alpha} is necessary but not sufficient for the formation of memory CD8 T cells during viral infection PNAS, July 10, 2007; 104(28): 11730 - 11735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Xiao, J. M. Curtsinger, M. Prlic, S. C. Jameson, and M. F. Mescher The CD8 T cell response to vaccinia virus exhibits site-dependent heterogeneity of functional responses Int. Immunol., June 1, 2007; 19(6): 733 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Tripathi, T. C. Mitchell, F. Finkelman, and D. A. Hildeman Cutting Edge: Limiting Amounts of IL-7 Do Not Control Contraction of CD4+ T Cell Responses J. Immunol., April 1, 2007; 178(7): 4027 - 4031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Castellino and R. N. Germain Chemokine-Guided CD4+ T Cell Help Enhances Generation of IL-6R{alpha}highIL-7R{alpha}high Prememory CD8+ T Cells J. Immunol., January 15, 2007; 178(2): 778 - 787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Klonowski, K. J. Williams, A. L. Marzo, and L. Lefrancois Cutting Edge: IL-7-Independent Regulation of IL-7 Receptor {alpha} Expression and Memory CD8 T Cell Development J. Immunol., October 1, 2006; 177(7): 4247 - 4251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Sun, S. M. Lehar, and M. J. Bevan Augmented IL-7 Signaling during Viral Infection Drives Greater Expansion of Effector T Cells but Does Not Enhance Memory J. Immunol., October 1, 2006; 177(7): 4458 - 4463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Buentke, A. Mathiot, M. Tolaini, J. Di Santo, R. Zamoyska, and B. Seddon Do CD8 effector cells need IL-7R expression to become resting memory cells? Blood, September 15, 2006; 108(6): 1949 - 1956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. N. D'Souza and S. M. Hedrick Cutting Edge: Latecomer CD8 T Cells Are Imprinted with a Unique Differentiation Program J. Immunol., July 15, 2006; 177(2): 777 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. R. Moulton, N. D. Bushar, D. B. Leeser, D. S. Patke, and D. L. Farber Divergent Generation of Heterogeneous Memory CD4 T Cells J. Immunol., July 15, 2006; 177(2): 869 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jabbari and J. T. Harty The generation and modulation of antigen-specific memory CD8 T cell responses J. Leukoc. Biol., July 1, 2006; 80(1): 16 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shi and J. Xiang CD4+ T cell-independent maintenance and expansion of memory CD8+ T cells derived from in vitro dendritic cell activation Int. Immunol., June 1, 2006; 18(6): 887 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. MacLeod, M. J. Kwakkenbos, A. Crawford, S. Brown, B. Stockinger, K. Schepers, T. Schumacher, and D. Gray CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40 J. Exp. Med., April 17, 2006; 203(4): 897 - 906. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
