HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fields, M. L. Articles by Erikson, J. Search for Related Content PubMed PubMed Citation Articles by Fields, M. L. Articles by Erikson, J.

CD4⁺CD25⁺ Regulatory T Cells Inhibit the Maturation but Not the Initiation of an Autoantibody Response¹

The Wistar Institute, Philadelphia, PA 19104

To investigate the mechanism by which T regulatory (Treg) cells may control the early onset of autoimmunity, we have used an adoptive transfer model to track Treg, Th, and anti-chromatin B cell interactions in vivo. We show that anti-chromatin B cells secrete Abs by day 8 in vivo upon provision of undeviated, Th1- or Th2-type CD4⁺ T cell help, but this secretion is blocked by the coinjection of CD4⁺CD25⁺ Treg cells. Although Treg cells do not interfere with the initial follicular entry or activation of Th or B cells at day 3, ICOS levels on Th cells are decreased. Furthermore, Treg cells must be administered during the initial phases of the Ab response to exert full suppression of autoantibody production. These studies indicate that CD25⁺ Treg cells act to inhibit the maturation, rather than the initiation, of autoantibody responses.

This article has been cited by other articles:

				Y. Li, L. Ma, D. Yin, J. Shen, and A. S. Chong Long-Term Control of Alloreactive B Cell Responses by the Suppression of T Cell Help J. Immunol., May 1, 2008; 180(9): 6077 - 6084. [Abstract] [Full Text] [PDF]

				Y. Li, L. Ma, J. Shen, and A. S. Chong Peripheral deletion of mature alloreactive B cells induced by costimulation blockade PNAS, July 17, 2007; 104(29): 12093 - 12098. [Abstract] [Full Text] [PDF]

				A.-M Cepika, I. Marinic, J. Morovic-Vergles, D. Soldo-Juresa, and A. Gagro Letter To the Editor: Effect of steroids on the frequency of regulatory T Cells and expression of FOXP3 in a patient with systemic lupus erythematosus: a two-year follow-up Lupus, May 1, 2007; 16(5): 374 - 377. [PDF]

				K. Horikawa, S. W. Martin, S. L. Pogue, K. Silver, K. Peng, K. Takatsu, and C. C. Goodnow Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors J. Exp. Med., April 16, 2007; 204(4): 759 - 769. [Abstract] [Full Text] [PDF]

				B. D. Hondowicz, S. T. Alexander, W. J. Quinn III, A. J. Pagan, M. H. Metzgar, M. P. Cancro, and J. Erikson The role of BLyS/BLyS receptors in anti-chromatin B cell regulation Int. Immunol., April 1, 2007; 19(4): 465 - 475. [Abstract] [Full Text] [PDF]

				W. Gurr, M. Shaw, Y. Li, and R. Sherwin RegII Is a {beta}-Cell Protein and Autoantigen in Diabetes of NOD Mice Diabetes, January 1, 2007; 56(1): 34 - 40. [Abstract] [Full Text] [PDF]

				G. C. Bosma, J. Oshinsky, K. Kiefer, P. B. Nakajima, D. Charan, C. Congelton, M. Radic, and M. J. Bosma Development of Functional B Cells in a Line of SCID Mice with Transgenes Coding for Anti-Double-Stranded DNA Antibody J. Immunol., January 15, 2006; 176(2): 889 - 898. [Abstract] [Full Text] [PDF]