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Cutting Edge: Bacterial Modulation of Epithelial Signaling via Changes in Neddylation of Cullin-1¹

Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta GA, 30322

The human enteric flora plays a significant role in intestinal health and disease. Certain enteric bacteria can inhibit the NF-B pathway by blockade of IB- ubiquitination. IB- ubiquitination is catalyzed by the E3-SCF^TrCP ubiquitin ligase, which is itself regulated via covalent modification of the cullin-1 subunit by the ubiquitin-like protein NEDD8. Neddylation is a biochemical event associated with diverse cellular processes related to cell signaling, however, physiological regulation of cullin neddylation has not been described in mammalian systems. We report that interaction of nonpathogenic bacteria with epithelial cells resulted in a rapid loss of neddylated Cul-1 and consequent repression of the NF-B pathway. This observation may explain the ability of intestinal bacterial communities to influence diverse eukaryotic processes in general and inflammatory tolerance of the mammalian intestinal epithelia specifically.

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The JI 2005 175: 4159-4160. [Full Text]  

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