| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
,
,
* Department of Environmental and Molecular Toxicology,
Department of Microbiology, and
Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331; and
AVI Biopharma, Corvallis, OR 97333
Activation of the aryl hydrocarbon receptor (AhR) by its most potent ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), leads to immune suppression in mice. Although the underlying mechanisms responsible for AhR-mediated immune suppression are not known, previous studies have shown that activation of the AhR must occur within the first 3 days of an immune response and that CD4+ T cells are primary targets. Using the B6-into-B6D2F1 model of an acute graft-vs-host response, we show that activation of AhR in donor T cells leads to the generation of a subpopulation of CD4+ T cells that expresses high levels of CD25, along with CD62Llow, CTLA-4, and glucocorticoid-induced TNFR. These donor-derived CD4+CD25+ cells also display functional characteristics of regulatory T cells in vitro. These findings suggest a novel role for AhR in the induction of regulatory T cells and provide a new perspective on the mechanisms that underlie the profound immune suppression induced by exposure to TCDD.
This article has been cited by other articles:
|
|
 |
|
  J Li and R. McMurray Effects of chronic exposure to DDT and TCDD on disease activity in murine systemic lupus erythematosus Lupus, October 1, 2009; 18(11): 941 - 949. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Kimura, T. Naka, T. Nakahama, I. Chinen, K. Masuda, K. Nohara, Y. Fujii-Kuriyama, and T. Kishimoto Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses J. Exp. Med., August 31, 2009; 206(9): 2027 - 2035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nohara, T. Suzuki, K. Ao, H. Murai, Y. Miyamoto, K. Inouye, X. Pan, H. Motohashi, Y. Fujii-Kuriyama, M. Yamamoto, et al. Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-{gamma} production in mice but does not suppress Th2-cytokine production or antibody production Int. Immunol., July 1, 2009; 21(7): 769 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Jux, S. Kadow, and C. Esser Langerhans Cell Maturation and Contact Hypersensitivity Are Impaired in Aryl Hydrocarbon Receptor-Null Mice J. Immunol., June 1, 2009; 182(11): 6709 - 6717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Veldhoen, K. Hirota, J. Christensen, A. O'Garra, and B. Stockinger Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells J. Exp. Med., January 16, 2009; 206(1): 43 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. B. Marshall, W. R. Vorachek, L. B. Steppan, D. V. Mourich, and N. I. Kerkvliet Functional Characterization and Gene Expression Analysis of CD4+CD25+ Regulatory T Cells Generated in Mice Treated with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin J. Immunol., August 15, 2008; 181(4): 2382 - 2391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Lawrence, M. S. Denison, H. Novak, B. A. Vorderstrasse, N. Harrer, W. Neruda, C. Reichel, and M. Woisetschlager Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound Blood, August 15, 2008; 112(4): 1158 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hauben, S. Gregori, E. Draghici, B. Migliavacca, S. Olivieri, M. Woisetschlager, and M. G. Roncarolo Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells Blood, August 15, 2008; 112(4): 1214 - 1222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kimura, T. Naka, K. Nohara, Y. Fujii-Kuriyama, and T. Kishimoto Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells PNAS, July 15, 2008; 105(28): 9721 - 9726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Hogaboam, A. J. Moore, and B. P. Lawrence The Aryl Hydrocarbon Receptor Affects Distinct Tissue Compartments during Ontogeny of the Immune System Toxicol. Sci., March 1, 2008; 102(1): 160 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Z. Shi, N. G. Faith, Y. Nakayama, M. Suresh, H. Steinberg, and C. J. Czuprynski The Aryl Hydrocarbon Receptor Is Required for Optimal Resistance to Listeria monocytogenes Infection in Mice J. Immunol., November 15, 2007; 179(10): 6952 - 6962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Andrew, V. Bernardo, L. A. Warnke, J. C. Davey, T. Hampton, R. A. Mason, J. E. Thorpe, M. A. Ihnat, and J. W. Hamilton Exposure to Arsenic at Levels Found in U.S. Drinking Water Modifies Expression in the Mouse Lung Toxicol. Sci., November 1, 2007; 100(1): 75 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Lawrence, A. D. Roberts, J. J. Neumiller, J. A. Cundiff, and D. L. Woodland Aryl Hydrocarbon Receptor Activation Impairs the Priming but Not the Recall of Influenza Virus-Specific CD8+ T Cells in the Lung J. Immunol., November 1, 2006; 177(9): 5819 - 5828. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
