The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lim, H. W.
Right arrow Articles by Kim, C. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lim, H. W.
Right arrow Articles by Kim, C. H.
The Journal of Immunology, 2005, 175: 4180-4183.
Copyright © 2005 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells1

Hyung W. Lim*, Peter Hillsamer{dagger}, Allison H. Banham{ddagger} and Chang H. Kim2,*

* Laboratory of Immunology and Hematopoiesis, Department of Pathobiology; Purdue Cancer Center; Bindley Bioscience Center; and Biochemistry and Molecular Biology Program, Purdue University, West Lafayette, IN 47907; {dagger} Sagamore Surgical Center, Lafayette, IN 47909; and {ddagger} Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom

Regulatory T cells (Tregs) can potentially migrate to the B cell areas of secondary lymphoid tissues and suppress T cell-dependent B cell Ig response. T cell-dependent Ig response requires B cell stimulation by Th cells. It has been unknown whether Tregs can directly suppress B cells or whether they must suppress Th cells to suppress B cell response. We report here that Foxp3+ Tregs are found in T-B area borders and within germinal centers of human lymphoid tissues and can directly suppress B cell Ig response. Although Tregs can effectively suppress T cells, they can also directly suppress B cell response without the need to first suppress Th cells. The direct suppression of B cell Ig production by Tregs is accompanied by inhibition of Ig class switch recombination.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
Y. Li, L. Ma, D. Yin, J. Shen, and A. S. Chong
Long-Term Control of Alloreactive B Cell Responses by the Suppression of T Cell Help
J. Immunol., May 1, 2008; 180(9): 6077 - 6084.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Rynda, M. Maddaloni, D. Mierzejewska, J. Ochoa-Reparaz, T. Maslanka, K. Crist, C. Riccardi, B. Barszczewska, K. Fujihashi, J. R. McGhee, et al.
Low-Dose Tolerance Is Mediated by the Microfold Cell Ligand, Reovirus Protein {sigma}1
J. Immunol., April 15, 2008; 180(8): 5187 - 5200.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Terme, N. Chaput, B. Combadiere, A. Ma, T. Ohteki, and L. Zitvogel
Regulatory T Cells Control Dendritic Cell/NK Cell Cross-Talk in Lymph Nodes at the Steady State by Inhibiting CD4+ Self-Reactive T Cells
J. Immunol., April 1, 2008; 180(7): 4679 - 4686.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
T. Bryn, S. Yaqub, M. Mahic, K. Henjum, E. M. Aandahl, and K. Tasken
LPS-activated monocytes suppress T-cell immune responses and induce FOXP3+ T cells through a COX-2-PGE2-dependent mechanism
Int. Immunol., February 1, 2008; 20(2): 235 - 245.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
A. Tzankov, C. Meier, P. Hirschmann, P. Went, S. A. Pileri, and S. Dirnhofer
Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma
Haematologica, February 1, 2008; 93(2): 193 - 200.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Li, E. J. Gowans, C. Chougnet, M. Plebanski, and U. Dittmer
Natural Regulatory T Cells and Persistent Viral Infection
J. Virol., January 1, 2008; 82(1): 21 - 30.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
H. W. Lim and C. H. Kim
Loss of IL-7 Receptor {alpha} on CD4+ T Cells Defines Terminally Differentiated B Cell-Helping Effector T Cells in a B Cell-Rich Lymphoid Tissue
J. Immunol., December 1, 2007; 179(11): 7448 - 7456.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C.-Q. Xia, R. Peng, Y. Qiu, M. Annamalai, D. Gordon, and M. J. Clare-Salzler
Transfusion of Apoptotic {beta}-Cells Induces Immune Tolerance to {beta}-Cell Antigens and Prevents Type 1 Diabetes in NOD Mice
Diabetes, August 1, 2007; 56(8): 2116 - 2123.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Li, L. Ma, J. Shen, and A. S. Chong
Peripheral deletion of mature alloreactive B cells induced by costimulation blockade
PNAS, July 17, 2007; 104(29): 12093 - 12098.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. Herve, I. Isnardi, Y.-s. Ng, J. B. Bussel, H. D. Ochs, C. Cunningham-Rundles, and E. Meffre
CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance
J. Exp. Med., July 9, 2007; 204(7): 1583 - 1593.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Pabst, H. Schirutschke, G. Ehninger, M. Bornhauser, and U. Platzbecker
The Graft Content of Donor T Cells Expressing {gamma}{delta}TCR+ and CD4+foxp3+ Predicts the Risk of Acute Graft versus Host Disease after Transplantation of Allogeneic Peripheral Blood Stem Cells from Unrelated Donors
Clin. Cancer Res., May 15, 2007; 13(10): 2916 - 2922.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
K. Horikawa, S. W. Martin, S. L. Pogue, K. Silver, K. Peng, K. Takatsu, and C. C. Goodnow
Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors
J. Exp. Med., April 16, 2007; 204(4): 759 - 769.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
I L Huibregtse, A U van Lent, and S J H van Deventer
Immunopathogenesis of IBD: insufficient suppressor function in the gut?
Gut, April 1, 2007; 56(4): 584 - 592.
[Full Text] [PDF]

Home page
 BloodHome page
V. H. Nguyen, R. Zeiser, D. L. daSilva, D. S. Chang, A. Beilhack, C. H. Contag, and R. S. Negrin
In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation
Blood, March 15, 2007; 109(6): 2649 - 2656.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. J. Callaghan, F. J. Rouhani, M. C. Negus, A. J. Curry, E. M. Bolton, J. A. Bradley, and G. J. Pettigrew
Abrogation of Antibody-Mediated Allograft Rejection by Regulatory CD4 T Cells with Indirect Allospecificity
J. Immunol., February 15, 2007; 178(4): 2221 - 2228.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Valencia, C. Yarboro, G. Illei, and P. E. Lipsky
Deficient CD4+CD25high T Regulatory Cell Function in Patients with Active Systemic Lupus Erythematosus
J. Immunol., February 15, 2007; 178(4): 2579 - 2588.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
W. Gurr, M. Shaw, Y. Li, and R. Sherwin
RegII Is a {beta}-Cell Protein and Autoantigen in Diabetes of NOD Mice
Diabetes, January 1, 2007; 56(1): 34 - 40.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
N. Ralainirina, A. Poli, T. Michel, L. Poos, E. Andres, F. Hentges, and J. Zimmer
Control of NK cell functions by CD4+CD25+ regulatory T cells
J. Leukoc. Biol., January 1, 2007; 81(1): 144 - 153.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. H. Lee, S. G. Kang, and C. H. Kim
FoxP3+ T Cells Undergo Conventional First Switch to Lymphoid Tissue Homing Receptors in Thymus but Accelerated Second Switch to Nonlymphoid Tissue Homing Receptors in Secondary Lymphoid Tissues
J. Immunol., January 1, 2007; 178(1): 301 - 311.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z.-X. Zhang, Y. Ma, H. Wang, J. Arp, J. Jiang, X. Huang, K. M. He, B. Garcia, J. Madrenas, and R. Zhong
Double-Negative T Cells, Activated by Xenoantigen, Lyse Autologous B and T Cells Using a Perforin/Granzyme-Dependent, Fas-Fas Ligand-Independent Pathway
J. Immunol., November 15, 2006; 177(10): 6920 - 6929.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Carreras, A. Lopez-Guillermo, B. C. Fox, L. Colomo, A. Martinez, G. Roncador, E. Montserrat, E. Campo, and A. H. Banham
High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma
Blood, November 1, 2006; 108(9): 2957 - 2964.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Beyer and J. L. Schultze
Regulatory T cells in cancer
Blood, August 1, 2006; 108(3): 804 - 811.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. W. Lim, H. E. Broxmeyer, and C. H. Kim
Regulation of Trafficking Receptor Expression in Human Forkhead Box P3+ Regulatory T Cells
J. Immunol., July 15, 2006; 177(2): 840 - 851.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
K. Wing, Z. Fehervari, and S. Sakaguchi
Emerging possibilities in the development and function of regulatory T cells
Int. Immunol., July 1, 2006; 18(7): 991 - 1000.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D.-M. Zhao, A. M. Thornton, R. J. DiPaolo, and E. M. Shevach
Activated CD4+CD25+ T cells selectively kill B lymphocytes
Blood, May 15, 2006; 107(10): 3925 - 3932.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Z.-Z. Yang, A. J. Novak, M. J. Stenson, T. E. Witzig, and S. M. Ansell
Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma
Blood, May 1, 2006; 107(9): 3639 - 3646.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.