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The Journal of Immunology, 2005, 175: 3262-3267.
Copyright © 2005 by The American Association of Immunologists

Regulation of Aged Humoral Immune Defense against Pneumococcal Bacteria by IgM Memory B Cell

Yuhui Shi*, Takashi Yamazaki*, Yoshio Okubo{dagger}, Yoshio Uehara{ddagger}, Kazuo Sugane* and Kazunaga Agematsu1,*

* Department of Infectious Immunology and {dagger} First Department of Internal Medicine, Shinshu University, Graduate School of Medicine, Matsumoto, Japan; and {ddagger} Department of General Medicine, Kochi Medical School, Koch, Japan

Elderly persons have a high incidence of lethal infections by encapsulated bacteria. However, mechanisms involved in their poor defense and maintenance of immunological memory have been poorly understood. The present study characterized the population of B cells known as IgM memory B cell compartment and their response by pneumococcal vaccine in elderly people. CD27+ memory B cells, particularly IgD+IgM+CD27+ IgM memory B cells, had dramatically declined in the aged. Their Ig syntheses by B cells and the differentiation into plasma cells were diminished in vitro compared with those in adults. A rise of anti-pneumococcal IgM in sera of elderly persons was found with lower levels compared with those in adults after pneumococcal vaccination. Although diminished function itself of aged B cells surely exist, decline of the IgM memory B cell pool is expected to result in a poor humoral immunity against pneumococcal infection in elderly people.




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