| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Institute of Immunology and
Institute of Toxicology, Hannover Medical School, Hannover, Germany
Sphingosine-1-phosphate (S1P) represents a potent modulator of diverse cellular activities, including lymphocyte trafficking and maintenance of lymphocyte homeostasis. The five known receptors for S1P (S1P1–5) belong to the family of G protein-coupled receptors. Upon binding S1P, they act downstream via heterotrimeric G proteins on members of the small GTPase family (Cdc42/Rac/Rho), evoking a S1P receptor-dependent activation pattern of Cdc42, Rac, and Rho, respectively. This, in turn, triggers cytoskeletal rearrangements determining cellular morphology and movement. In this study we investigated the effects of S1P on murine dendritic cells (DC). Mature DC, but not immature in vitro differentiated DC, were found to migrate to S1P, a phenomenon that correlated to the up-regulation of S1P1 and S1P3 in maturing DC. The same pattern of S1P receptor regulation could be observed in vivo on skin DC after their activation and migration into the lymph node. The migration-inducing effect of S1P could be severely hampered by application of the S1P analogon FTY720 in vitro and in vivo. A similar, yet more pronounced, block was observed upon preventing Cdc42/Rac and/or Rho activation by specific inhibitors. These results suggest that S1P-mediated signaling plays a pivotal role in the life cycle of DC.
This article has been cited by other articles:
|
|
 |
|
  S. Seth, A.-M. Georgoudaki, B. J. Chambers, Q. Qiu, E. Kremmer, M. K. Maier, N. Czeloth, I. Ravens, R. Foerster, and G. Bernhardt Heterogeneous expression of the adhesion receptor CD226 on murine NK and T cells and its function in NK-mediated killing of immature dendritic cells J. Leukoc. Biol., July 1, 2009; 86(1): 91 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Meyer, S. Seth, J. Albrecht, M. K. Maier, L. d. Pasquier, I. Ravens, L. Dreyer, R. Burger, M. Gramatzki, R. Schwinzer, et al. CD96 Interaction with CD155 via Its First Ig-like Domain Is Modulated by Alternative Splicing or Mutations in Distal Ig-like Domains J. Biol. Chem., January 23, 2009; 284(4): 2235 - 2244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. I. Hammerschmidt, M. Ahrendt, U. Bode, B. Wahl, E. Kremmer, R. Forster, and O. Pabst Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo J. Exp. Med., October 27, 2008; 205(11): 2483 - 2490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Marsolais, B. Hahm, K. H. Edelmann, K. B. Walsh, M. Guerrero, Y. Hatta, Y. Kawaoka, E. Roberts, M. B. A. Oldstone, and H. Rosen Local Not Systemic Modulation of Dendritic Cell S1P Receptors in Lung Blunts Virus-Specific Immune Responses to Influenza Mol. Pharmacol., September 1, 2008; 74(3): 896 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Gollmann, H. Neuwirt, C. H. Tripp, H. Mueller, G. Konwalinka, C. Heufler, N. Romani, and M. Tiefenthaler Sphingosine-1-phosphate receptor type-1 agonism impairs blood dendritic cell chemotaxis and skin dendritic cell migration to lymph nodes under inflammatory conditions Int. Immunol., July 1, 2008; 20(7): 911 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. M. Davalos-Misslitz, T. Worbs, S. Willenzon, G. Bernhardt, and R. Forster Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice Blood, December 15, 2007; 110(13): 4351 - 4359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Chan, W. Peters, Y. Xu, J. Chun, R. V. Farese Jr, and S. Cases LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA) J. Leukoc. Biol., November 1, 2007; 82(5): 1193 - 1200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Czeloth, A. Schippers, N. Wagner, W. Muller, B. Kuster, G. Bernhardt, and R. Forster Sphingosine-1 Phosphate Signaling Regulates Positioning of Dendritic Cells within the Spleen J. Immunol., November 1, 2007; 179(9): 5855 - 5863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Taylor, M. J. Ehrhardt, C. J. Lees, J. Tolar, B. J. Weigel, A. Panoskaltsis-Mortari, J. S. Serody, V. Brinkmann, and B. R. Blazar Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD) Blood, November 1, 2007; 110(9): 3480 - 3488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kurashima, J. Kunisawa, M. Higuchi, M. Gohda, I. Ishikawa, N. Takayama, M. Shimizu, and H. Kiyono Sphingosine 1-Phosphate-Mediated Trafficking of Pathogenic Th2 and Mast Cells for the Control of Food Allergy J. Immunol., August 1, 2007; 179(3): 1577 - 1585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. D. Jung, J. S. Lee, Y. J. Kim, Y.-I. Jeong, C.-M. Lee, T. Baumruker, A. Billlich, Y. Banno, M. G. Lee, S.-C. Ahn, et al. Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells Int. Immunol., April 1, 2007; 19(4): 411 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Maeda, H. Matsuyuki, K. Shimano, H. Kataoka, K. Sugahara, and K. Chiba Migration of CD4 T Cells and Dendritic Cells toward Sphingosine 1-Phosphate (S1P) Is Mediated by Different Receptor Subtypes: S1P Regulates the Functions of Murine Mature Dendritic Cells via S1P Receptor Type 3 J. Immunol., March 15, 2007; 178(6): 3437 - 3446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Thurnher Lipids in dendritic cell biology: messengers, effectors, and antigens J. Leukoc. Biol., January 1, 2007; 81(1): 154 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Pabst, H. Herbrand, S. Willenzon, T. Worbs, A. Schippers, W. Muller, G. Bernhardt, and R. Forster Enhanced FTY720-Mediated Lymphocyte Homing Requires G{alpha}i Signaling and Depends on beta2 and beta7 Integrin J. Immunol., February 1, 2006; 176(3): 1474 - 1480. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
