| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
,
,¶
* Antiviral Innate Immunity Project, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan;
Department of Vascular Biology, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan;
21st Century Center of Excellence Program, Graduate School of Medicine, University of Tokyo, Tokyo, Japan;
National Institute of Advanced Industrial Science and Technology, Gene Function Research Center, Tsukuba Science City, Japan;
¶ Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, Tokyo, Japan;
|| Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390;
# Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan;
** Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan; and
Department of Virology III, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
The cellular protein retinoic acid-inducible gene I (RIG-I) senses intracellular viral infection and triggers a signal for innate antiviral responses including the production of type I IFN. RIG-I contains a domain that belongs to a DExD/H-box helicase family and exhibits an N-terminal caspase recruitment domain (CARD) homology. There are three genes encoding RIG-I-related proteins in human and mouse genomes. Melanoma differentiation associated gene 5 (MDA5), which consists of CARD and a helicase domain, functions as a positive regulator, similarly to RIG-I. Both proteins sense viral RNA with a helicase domain and transmit a signal downstream by CARD; thus, these proteins share overlapping functions. Another protein, LGP2, lacks the CARD homology and functions as a negative regulator by interfering with the recognition of viral RNA by RIG-I and MDA5. The nonstructural protein 3/4A protein of hepatitis C virus blocks the signaling by RIG-I and MDA5; however, the V protein of the Sendai virus selectively abrogates the MDA5 function. These results highlight ingenious mechanisms for initiating antiviral innate immune responses and the action of virus-encoded inhibitors.
This article has been cited by other articles:
|
|
 |
|
  J. Drahos and V. R. Racaniello Cleavage of IPS-1 in Cells Infected with Human Rhinovirus J. Virol., November 15, 2009; 83(22): 11581 - 11587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Olejniczak, P. Galka, and W. J. Krzyzosiak Sequence-non-specific effects of RNA interference triggers and microRNA regulators Nucleic Acids Res., October 20, 2009; (2009) gkp829v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Swedan, A. Musiyenko, and S. Barik Respiratory Syncytial Virus Nonstructural Proteins Decrease Levels of Multiple Members of the Cellular Interferon Pathways J. Virol., October 1, 2009; 83(19): 9682 - 9693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kenworthy, D. Lambert, F. Yang, N. Wang, Z. Chen, H. Zhu, F. Zhu, C. Liu, K. Li, and H. Tang Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation Nucleic Acids Res., October 1, 2009; 37(19): 6587 - 6599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Szretter, M. A. Samuel, S. Gilfillan, A. Fuchs, M. Colonna, and M. S. Diamond The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis J. Virol., September 15, 2009; 83(18): 9329 - 9338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Biacchesi, M. LeBerre, A. Lamoureux, Y. Louise, E. Lauret, P. Boudinot, and M. Bremont Mitochondrial Antiviral Signaling Protein Plays a Major Role in Induction of the Fish Innate Immune Response against RNA and DNA Viruses J. Virol., August 15, 2009; 83(16): 7815 - 7827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Miyake, Y. Kumagai, H. Kato, Z. Guo, K. Matsushita, T. Satoh, T. Kawagoe, H. Kumar, M. H. Jang, T. Kawai, et al. Poly I:C-Induced Activation of NK Cells by CD8{alpha}+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways J. Immunol., August 15, 2009; 183(4): 2522 - 2528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Abe, Y. Kaname, X. Wen, H. Tani, K. Moriishi, S. Uematsu, O. Takeuchi, K. J. Ishii, T. Kawai, S. Akira, et al. Baculovirus Induces Type I Interferon Production through Toll-Like Receptor-Dependent and -Independent Pathways in a Cell-Type-Specific Manner J. Virol., August 1, 2009; 83(15): 7629 - 7640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schmidt, T. Schwerd, W. Hamm, J. C. Hellmuth, S. Cui, M. Wenzel, F. S. Hoffmann, M.-C. Michallet, R. Besch, K.-P. Hopfner, et al. 5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I PNAS, July 21, 2009; 106(29): 12067 - 12072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Parisien, D. Bamming, A. Komuro, A. Ramachandran, J. J. Rodriguez, G. Barber, R. D. Wojahn, and C. M. Horvath A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2 J. Virol., July 15, 2009; 83(14): 7252 - 7260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. B. Johnsen, T. T. Nguyen, B. Bergstroem, K. A. Fitzgerald, and M. W. Anthonsen The Tyrosine Kinase c-Src Enhances RIG-I (Retinoic Acid-inducible Gene I)-elicited Antiviral Signaling J. Biol. Chem., July 10, 2009; 284(28): 19122 - 19131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takahasi, H. Kumeta, N. Tsuduki, R. Narita, T. Shigemoto, R. Hirai, M. Yoneyama, M. Horiuchi, K. Ogura, T. Fujita, et al. Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains: IDENTIFICATION OF THE RNA RECOGNITION LOOP IN RIG-I-LIKE RECEPTORS J. Biol. Chem., June 26, 2009; 284(26): 17465 - 17474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Genin, R. Lin, J. Hiscott, and A. Civas Differential Regulation of Human Interferon A Gene Expression by Interferon Regulatory Factors 3 and 7 Mol. Cell. Biol., June 15, 2009; 29(12): 3435 - 3450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sioud and Y. Floisand NOD2/CARD15 on bone marrow CD34+ hematopoietic cells mediates induction of cytokines and cell differentiation J. Leukoc. Biol., June 1, 2009; 85(6): 939 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Sun, Y. Li, L. Chen, H. Chen, F. You, X. Zhou, Y. Zhou, Z. Zhai, D. Chen, and Z. Jiang ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization PNAS, May 26, 2009; 106(21): 8653 - 8658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yajima and K. U. Knowlton Viral Myocarditis: From the Perspective of the Virus Circulation, May 19, 2009; 119(19): 2615 - 2624. [Full Text] [PDF]
|
|
|
|
|
|
X. Li, C. T. Ranjith-Kumar, M. T. Brooks, S. Dharmaiah, A. B. Herr, C. Kao, and P. Li The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA J. Biol. Chem., May 15, 2009; 284(20): 13881 - 13891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shigemoto, M. Kageyama, R. Hirai, J. Zheng, M. Yoneyama, and T. Fujita Identification of Loss of Function Mutations in Human Genes Encoding RIG-I and MDA5: IMPLICATIONS FOR RESISTANCE TO TYPE I DIABETES J. Biol. Chem., May 15, 2009; 284(20): 13348 - 13354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Mikkelsen, S. B. Jensen, S. Chiliveru, J. Melchjorsen, I. Julkunen, M. Gaestel, J. S. C. Arthur, R. A. Flavell, S. Ghosh, and S. R. Paludan RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells: DEPENDENCE ON TRAF2 AND TAK1 J. Biol. Chem., April 17, 2009; 284(16): 10774 - 10782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bamming and C. M. Horvath Regulation of Signal Transduction by Enzymatically Inactive Antiviral RNA Helicase Proteins MDA5, RIG-I, and LGP2 J. Biol. Chem., April 10, 2009; 284(15): 9700 - 9712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Mogensen Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses Clin. Microbiol. Rev., April 1, 2009; 22(2): 240 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Prins, W. B. Cardenas, and C. F. Basler Ebola Virus Protein VP35 Impairs the Function of Interferon Regulatory Factor-Activating Kinases IKK{varepsilon} and TBK-1 J. Virol., April 1, 2009; 83(7): 3069 - 3077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Pippig, J. C. Hellmuth, S. Cui, A. Kirchhofer, K. Lammens, A. Lammens, A. Schmidt, S. Rothenfusser, and K.-P. Hopfner The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA Nucleic Acids Res., April 1, 2009; 37(6): 2014 - 2025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yang, H.-X. Shi, X.-Y. Liu, Y.-F. Shan, B. Wei, S. Chen, and C. Wang TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response J. Immunol., March 15, 2009; 182(6): 3782 - 3792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Miyahira, A. Shahangian, S. Hwang, R. Sun, and G. Cheng TANK-Binding Kinase-1 Plays an Important Role during In Vitro and In Vivo Type I IFN Responses to DNA Virus Infections J. Immunol., February 15, 2009; 182(4): 2248 - 2257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Xu, N. Xiao, F. Liu, H. Ren, and J. Gu Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria PNAS, February 3, 2009; 106(5): 1530 - 1535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Childs, J. Andrejeva, R. E. Randall, and S. Goodbourn Mechanism of mda-5 Inhibition by Paramyxovirus V Proteins J. Virol., February 1, 2009; 83(3): 1465 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Guo, D. Jiang, D. Ma, J. Chang, A. M. Dougherty, A. Cuconati, T. M. Block, and J.-T. Guo Activation of Pattern Recognition Receptor-Mediated Innate Immunity Inhibits the Replication of Hepatitis B Virus in Human Hepatocyte-Derived Cells J. Virol., January 15, 2009; 83(2): 847 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Oshiumi, M. Matsumoto, S. Hatakeyama, and T. Seya Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-{beta} Induction during the Early Phase of Viral Infection J. Biol. Chem., January 9, 2009; 284(2): 807 - 817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yoshida, G. Takaesu, H. Yoshida, F. Okamoto, T. Yoshioka, Y. Choi, S. Akira, T. Kawai, A. Yoshimura, and T. Kobayashi TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway J. Biol. Chem., December 26, 2008; 283(52): 36211 - 36220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Deng, M. Shi, M. Han, J. Zhong, Z. Li, W. Li, Y. Hu, L. Yan, J. Wang, Y. He, et al. Negative Regulation of Virus-triggered IFN-{beta} Signaling Pathway by Alternative Splicing of TBK1 J. Biol. Chem., December 19, 2008; 283(51): 35590 - 35597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Escribese, T. Kraus, E. Rhee, A. Fernandez-Sesma, C. B. Lopez, and T. M. Moran Estrogen inhibits dendritic cell maturation to RNA viruses Blood, December 1, 2008; 112(12): 4574 - 4584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Fensterl, C. L. White, M. Yamashita, and G. C. Sen Novel Characteristics of the Function and Induction of Murine p56 Family Proteins J. Virol., November 15, 2008; 82(22): 11045 - 11053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Kim and J.-Y. Yoo Active Caspase-1-Mediated Secretion of Retinoic Acid Inducible Gene-I J. Immunol., November 15, 2008; 181(10): 7324 - 7331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sarkar, R. DeSalle, and P. B. Fisher Evolution of MDA-5/RIG-I-dependent innate immunity: Independent evolution by domain grafting PNAS, November 4, 2008; 105(44): 17040 - 17045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Tamassia, V. Le Moigne, M. Rossato, M. Donini, S. McCartney, F. Calzetti, M. Colonna, F. Bazzoni, and M. A. Cassatella Activation of an Immunoregulatory and Antiviral Gene Expression Program in Poly(I:C)-Transfected Human Neutrophils J. Immunol., November 1, 2008; 181(9): 6563 - 6573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Roth-Cross, S. J. Bender, and S. R. Weiss Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia J. Virol., October 15, 2008; 82(20): 9829 - 9838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Bitko, A. Musiyenko, M. A. Bayfield, R. J. Maraia, and S. Barik Cellular La Protein Shields Nonsegmented Negative-Strand RNA Viral Leader RNA from RIG-I and Enhances Virus Growth by Diverse Mechanisms J. Virol., August 15, 2008; 82(16): 7977 - 7987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. N. Kalali, G. Kollisch, J. Mages, T. Muller, S. Bauer, H. Wagner, J. Ring, R. Lang, M. Mempel, and M. Ollert Double-Stranded RNA Induces an Antiviral Defense Status in Epidermal Keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-Mediated Differential Signaling J. Immunol., August 15, 2008; 181(4): 2694 - 2704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kato, O. Takeuchi, E. Mikamo-Satoh, R. Hirai, T. Kawai, K. Matsushita, A. Hiiragi, T. S. Dermody, T. Fujita, and S. Akira Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 J. Exp. Med., July 7, 2008; 205(7): 1601 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Saito and M. Gale Jr. Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity J. Exp. Med., July 7, 2008; 205(7): 1523 - 1527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, S. Wu, X. Jin, M. Li, S. Chen, J. L. Teeling, V. H. Perry, and J. Gu Retinoic Acid-Inducible Gene-I Mediates Late Phase Induction of TNF-{alpha} by Lipopolysaccharide J. Immunol., June 15, 2008; 180(12): 8011 - 8019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Murali, X. Li, C. T. Ranjith-Kumar, K. Bhardwaj, A. Holzenburg, P. Li, and C. C. Kao Structure and Function of LGP2, a DEX(D/H) Helicase That Regulates the Innate Immunity Response J. Biol. Chem., June 6, 2008; 283(23): 15825 - 15833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Day, I. A. Ramshaw, A. J. Ramsay, and C. Ranasinghe Differential Effects of the Type I Interferons {alpha}4, {beta}, and {epsilon} on Antiviral Activity and Vaccine Efficacy J. Immunol., June 1, 2008; 180(11): 7158 - 7166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Paun, J. T. Reinert, Z. Jiang, C. Medin, M. Y. Balkhi, K. A. Fitzgerald, and P. M. Pitha Functional Characterization of Murine Interferon Regulatory Factor 5 (IRF-5) and Its Role in the Innate Antiviral Response J. Biol. Chem., May 23, 2008; 283(21): 14295 - 14308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Wang, M. K. Choi, T. Ban, H. Yanai, H. Negishi, Y. Lu, T. Tamura, A. Takaoka, K. Nishikura, and T. Taniguchi Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules PNAS, April 8, 2008; 105(14): 5477 - 5482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gee, P. K. Chua, J. Gevorkyan, K. Klumpp, I. Najera, D. C. Swinney, and J. Deval Essential Role of the N-terminal Domain in the Regulation of RIG-I ATPase Activity J. Biol. Chem., April 4, 2008; 283(14): 9488 - 9496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Yount, L. Gitlin, T. M. Moran, and C. B. Lopez MDA5 Participates in the Detection of Paramyxovirus Infection and Is Essential for the Early Activation of Dendritic Cells in Response to Sendai Virus Defective Interfering Particles J. Immunol., April 1, 2008; 180(7): 4910 - 4918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kramer, B. M. Schulte, L. W. J. Toonen, P. M. Barral, P. B. Fisher, K. H. W. Lanke, J. M. D. Galama, F. J. M. van Kuppeveld, and G. J. Adema Phagocytosis of Picornavirus-Infected Cells Induces an RNA-Dependent Antiviral State in Human Dendritic Cells J. Virol., March 15, 2008; 82(6): 2930 - 2937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Kim, S.-Y. Hwang, T. Imaizumi, and J.-Y. Yoo Negative Feedback Regulation of RIG-I-Mediated Antiviral Signaling by Interferon-Induced ISG15 Conjugation J. Virol., February 1, 2008; 82(3): 1474 - 1483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Fredericksen, B. C. Keller, J. Fornek, M. G. Katze, and M. Gale Jr. Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1 J. Virol., January 15, 2008; 82(2): 609 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Randall and S. Goodbourn Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures J. Gen. Virol., January 1, 2008; 89(1): 1 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-M. Loo, J. Fornek, N. Crochet, G. Bajwa, O. Perwitasari, L. Martinez-Sobrido, S. Akira, M. A. Gill, A. Garcia-Sastre, M. G. Katze, et al. Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity J. Virol., January 1, 2008; 82(1): 335 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jung, H. Kato, Y. Kumagai, H. Kumar, T. Kawai, O. Takeuchi, and S. Akira Lymphocytoid Choriomeningitis Virus Activates Plasmacytoid Dendritic Cells and Induces a Cytotoxic T-Cell Response via MyD88 J. Virol., January 1, 2008; 82(1): 196 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Martinez, J Varade, J R Lamas, M Fernandez-Arquero, J A Jover, E G de la Concha, B Fernandez-Gutierrez, and E Urcelay Association of the IFIH1-GCA-KCNH7 chromosomal region with rheumatoid arthritis Ann Rheum Dis, January 1, 2008; 67(1): 137 - 138. [Full Text] [PDF]
|
|
|
|
|
|
M. Tasaka, N. Sakamoto, Y. Itakura, M. Nakagawa, Y. Itsui, Y. Sekine-Osajima, Y. Nishimura-Sakurai, C.-H. Chen, M. Yoneyama, T. Fujita, et al. Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response J. Gen. Virol., December 1, 2007; 88(12): 3323 - 3333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kanda, R. Steele, R. Ray, and R. B. Ray Hepatitis C Virus Infection Induces the Beta Interferon Signaling Pathway in Immortalized Human Hepatocytes J. Virol., November 15, 2007; 81(22): 12375 - 12381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Seago, L. Hilton, E. Reid, V. Doceul, J. Jeyatheesan, K. Moganeradj, J. McCauley, B. Charleston, and S. Goodbourn The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3 J. Gen. Virol., November 1, 2007; 88(11): 3002 - 3006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hirata, A. H. Broquet, L. Menchen, and M. F. Kagnoff Activation of Innate Immune Defense Mechanisms by Signaling through RIG-I/IPS-1 in Intestinal Epithelial Cells J. Immunol., October 15, 2007; 179(8): 5425 - 5432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gong, S. Hay, K. R. Marshall, A. W. Munro, and N. S. Scrutton DNA Binding Suppresses Human AIF-M2 Activity and Provides a Connection between Redox Chemistry, Reactive Oxygen Species, and Apoptosis J. Biol. Chem., October 12, 2007; 282(41): 30331 - 30340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsumiya, S. M. Prescott, and D. M. Stafforini IFN-{epsilon} Mediates TNF-{alpha}-Induced STAT1 Phosphorylation and Induction of Retinoic Acid-Inducible Gene-I in Human Cervical Cancer Cells J. Immunol., October 1, 2007; 179(7): 4542 - 4549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Abe, Y. Kaname, I. Hamamoto, Y. Tsuda, X. Wen, S. Taguwa, K. Moriishi, O. Takeuchi, T. Kawai, T. Kanto, et al. Hepatitis C Virus Nonstructural Protein 5A Modulates the Toll-Like Receptor-MyD88-Dependent Signaling Pathway in Macrophage Cell Lines J. Virol., September 1, 2007; 81(17): 8953 - 8966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nakamura, R. Ando, T. Nakazawa, T. Yudazono, N. Tsutsumi, N. Hatanaka, T. Ohgake, F. Hanaoka, and T. Eki Dicer-related drh-3 gene functions in germ-line development by maintenance of chromosomal integrity in Caenorhabditis elegans Genes Cells, September 1, 2007; 12(9): 997 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Jounai, F. Takeshita, K. Kobiyama, A. Sawano, A. Miyawaki, K.-Q. Xin, K. J. Ishii, T. Kawai, S. Akira, K. Suzuki, et al. The Atg5 Atg12 conjugate associates with innate antiviral immune responses PNAS, August 28, 2007; 104(35): 14050 - 14055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Terenzi, C. White, S. Pal, B. R. G. Williams, and G. C. Sen Tissue-Specific and Inducer-Specific Differential Induction of ISG56 and ISG54 in Mice J. Virol., August 15, 2007; 81(16): 8656 - 8665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sutherland, J. Davies, C. J. Owen, S. Vaikkakara, C. Walker, T. D. Cheetham, R. A. James, P. Perros, P. T. Donaldson, H. J. Cordell, et al. Genomic Polymorphism at the Interferon-Induced Helicase (IFIH1) Locus Contributes to Graves' Disease Susceptibility J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3338 - 3341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Prescott, P. R. Hall, V. S. Bondu-Hawkins, C. Ye, and B. Hjelle Early Innate Immune Responses to Sin Nombre Hantavirus Occur Independently of IFN Regulatory Factor 3, Characterized Pattern Recognition Receptors, and Viral Entry J. Immunol., August 1, 2007; 179(3): 1796 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Diao, S. Li, Y. Tian, M. Zhang, L.-G. Xu, Y. Zhang, R.-P. Wang, D. Chen, Z. Zhai, B. Zhong, et al. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase PNAS, July 10, 2007; 104(28): 11706 - 11711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Yount, T. M. Moran, and C. B. Lopez Cytokine-Independent Upregulation of MDA5 in Viral Infection J. Virol., July 1, 2007; 81(13): 7316 - 7319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yamazaki, K. Suzuki, E. Yamada, T. Yamada, F. Takeshita, M. Matsumoto, T. Mitsuhashi, T. Obara, K. Takano, and K. Sato Suppression of Iodide Uptake and Thyroid Hormone Synthesis with Stimulation of the Type I Interferon System by Double-Stranded Ribonucleic Acid in Cultured Human Thyroid Follicles Endocrinology, July 1, 2007; 148(7): 3226 - 3235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yasuda, C. Richez, J. W. Maciaszek, N. Agrawal, S. Akira, A. Marshak-Rothstein, and I. R. Rifkin Murine Dendritic Cell Type I IFN Production Induced by Human IgG-RNA Immune Complexes Is IFN Regulatory Factor (IRF)5 and IRF7 Dependent and Is Required for IL-6 Production J. Immunol., June 1, 2007; 178(11): 6876 - 6885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hiscott Triggering the Innate Antiviral Response through IRF-3 Activation J. Biol. Chem., May 25, 2007; 282(21): 15325 - 15329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yoneyama and T. Fujita Function of RIG-I-like Receptors in Antiviral Innate Immunity J. Biol. Chem., May 25, 2007; 282(21): 15315 - 15318. [Full Text] [PDF]
|
|
|
|
|
|
G. Cheng, J. Zhong, J. Chung, and F. V. Chisari Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells PNAS, May 22, 2007; 104(21): 9035 - 9040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Johnson, V. Albarani, M. Nguyen, M. Goldman, F. Willems, and E. Aksoy Protein Kinase C{alpha} Is Involved in Interferon Regulatory Factor 3 Activation and Type I Interferon-beta Synthesis J. Biol. Chem., May 18, 2007; 282(20): 15022 - 15032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Venkataraman, M. Valdes, R. Elsby, S. Kakuta, G. Caceres, S. Saijo, Y. Iwakura, and G. N. Barber Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses J. Immunol., May 15, 2007; 178(10): 6444 - 6455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Vitour and E. F. Meurs Regulation of Interferon Production by RIG-I and LGP2: A Lesson in Self-Control Sci. Signal., May 1, 2007; 2007(384): pe20 - pe20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yang, Y. Liang, L. Qu, Z. Chen, M. Yi, K. Li, and S. M. Lemon Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor PNAS, April 24, 2007; 104(17): 7253 - 7258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Johnson, D. M. Owen, and M. Gale Jr. Functional and Therapeutic Analysis of Hepatitis C Virus NS3{middle dot}4A Protease Control of Antiviral Immune Defense J. Biol. Chem., April 6, 2007; 282(14): 10792 - 10803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Onoguchi, M. Yoneyama, A. Takemura, S. Akira, T. Taniguchi, H. Namiki, and T. Fujita Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism J. Biol. Chem., March 9, 2007; 282(10): 7576 - 7581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Guo, L.-m. Chen, H. Zeng, J. A. Gomez, J. Plowden, T. Fujita, J. M. Katz, R. O. Donis, and S. Sambhara NS1 Protein of Influenza A Virus Inhibits the Function of Intracytoplasmic Pathogen Sensor, RIG-I Am. J. Respir. Cell Mol. Biol., March 1, 2007; 36(3): 263 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Balachandran, T. Venkataraman, P. B. Fisher, and G. N. Barber Fas-Associated Death Domain-Containing Protein-Mediated Antiviral Innate Immune Signaling Involves the Regulation of Irf7 J. Immunol., February 15, 2007; 178(4): 2429 - 2439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kawai and S. Akira Antiviral Signaling Through Pattern Recognition Receptors J. Biochem., February 1, 2007; 141(2): 137 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhou and S. Perlman Mouse Hepatitis Virus Does Not Induce Beta Interferon Synthesis and Does Not Inhibit Its Induction by Double-Stranded RNA J. Virol., January 15, 2007; 81(2): 568 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Saito, R. Hirai, Y.-M. Loo, D. Owen, C. L. Johnson, S. C. Sinha, S. Akira, T. Fujita, and M. Gale Jr. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2 PNAS, January 9, 2007; 104(2): 582 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Feng, M. Cerveny, Z. Yan, and B. He The VP35 Protein of Ebola Virus Inhibits the Antiviral Effect Mediated by Double-Stranded RNA-Dependent Protein Kinase PKR J. Virol., January 1, 2007; 81(1): 182 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Song, F. W Bazer, and T. E Spencer Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus Reproduction, January 1, 2007; 133(1): 285 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Komuro and C. M. Horvath RNA- and Virus-Independent Inhibition of Antiviral Signaling by RNA Helicase LGP2 J. Virol., December 15, 2006; 80(24): 12332 - 12342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sasai, M. Shingai, K. Funami, M. Yoneyama, T. Fujita, M. Matsumoto, and T. Seya NAK-Associated Protein 1 Participates in Both the TLR3 and the Cytoplasmic Pathways in Type I IFN Induction J. Immunol., December 15, 2006; 177(12): 8676 - 8683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hilton, K. Moganeradj, G. Zhang, Y.-H. Chen, R. E. Randall, J. W. McCauley, and S. Goodbourn The NPro Product of Bovine Viral Diarrhea Virus Inhibits DNA Binding by Interferon Regulatory Factor 3 and Targets It for Proteasomal Degradation J. Virol., December 1, 2006; 80(23): 11723 - 11732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Paladino, D. T. Cummings, R. S. Noyce, and K. L. Mossman The IFN-Independent Response to Virus Particle Entry Provides a First Line of Antiviral Defense That Is Independent of TLRs and Retinoic Acid-Inducible Gene I J. Immunol., December 1, 2006; 177(11): 8008 - 8016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pichlmair, O. Schulz, C. P. Tan, T. I. Naslund, P. Liljestrom, F. Weber, and C. Reis e Sousa RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates Science, November 10, 2006; 314(5801): 997 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Matsui, Y. Kumagai, H. Kato, S. Sato, T. Kawagoe, S. Uematsu, O. Takeuchi, and S. Akira Cutting Edge: Role of TANK-Binding Kinase 1 and Inducible I{kappa}B Kinase in IFN Responses against Viruses in Innate Immune Cells J. Immunol., November 1, 2006; 177(9): 5785 - 5789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Audige, M. Urosevic, E. Schlaepfer, R. Walker, D. Powell, S. Hallenberger, H. Joller, H.-U. Simon, R. Dummer, and R. F. Speck Anti-HIV State but Not Apoptosis Depends on IFN Signature in CD4+ T Cells J. Immunol., November 1, 2006; 177(9): 6227 - 6237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Samuel and M. S. Diamond Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral Evasion J. Virol., October 1, 2006; 80(19): 9349 - 9360. [Full Text] [PDF]
|
|
|
|
|
|
M. Severa, E. M. Coccia, and K. A. Fitzgerald Toll-like Receptor-dependent and -independent Viperin Gene Expression and Counter-regulation by PRDI-binding Factor-1/BLIMP1 J. Biol. Chem., September 8, 2006; 281(36): 26188 - 26195. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
