HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Related articles in The JI Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Robbins, C. S. Articles by Stampfli, M. R. Search for Related Content PubMed PubMed Citation Articles by Robbins, C. S. Articles by Stampfli, M. R. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Allergy

Mainstream Cigarette Smoke Exposure Attenuates Airway Immune Inflammatory Responses to Surrogate and Common Environmental Allergens in Mice, Despite Evidence of Increased Systemic Sensitization¹

Clinton S. Robbins^2,*,, Mahmoud A. Pouladi^2,*, Ramzi Fattouh^*, David E. Dawe^*, Neda Vujicic^*, Carl D. Richards^*,, Manel Jordana^*, Mark D. Inman and Martin R. Stampfli^3,*

^* Departments of Pathology and Molecular Medicine, Center for Gene Therapeutics, and Department of Biology and Department of Medicine, McMaster University, Hamilton, Ontario, Canada

The purpose of this study was to investigate the impact of mainstream cigarette smoke exposure (MTS) on allergic sensitization and the development of allergic inflammatory processes. Using two different experimental murine models of allergic airways inflammation, we present evidence that MTS increased cytokine production by splenocytes in response to OVA and ragweed challenge. Paradoxically, MTS exposure resulted in an overall attenuation of the immune inflammatory response, including a dramatic reduction in the number of eosinophils and activated (CD69⁺) and Th2-associated (T1ST2⁺) CD4 T lymphocytes in the lung. Although MTS did not impact circulating levels of OVA-specific IgE and IgG1, we observed a striking reduction in OVA-specific IgG2a production and significantly diminished airway hyperresponsiveness. MTS, therefore, plays a disparate role in the development of allergic responses, inducing a heightened state of allergen-specific sensitization, but dampening local immune inflammatory processes in the lung.

Related articles in The JI:

IN THIS ISSUE

The JI 2005 175: 2767-2768. [Full Text]  

This article has been cited by other articles:

				H. Yao, I. Edirisinghe, S.-R. Yang, S. Rajendrasozhan, A. Kode, S. Caito, D. Adenuga, and I. Rahman Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice Am. J. Pathol., May 1, 2008; 172(5): 1222 - 1237. [Abstract] [Full Text] [PDF]

				M. G. Min, D. J. Song, M. Miller, J. Y. Cho, S. McElwain, P. Ferguson, and D. H. Broide Coexposure to Environmental Tobacco Smoke Increases Levels of Allergen-Induced Airway Remodeling in Mice J. Immunol., April 15, 2007; 178(8): 5321 - 5328. [Abstract] [Full Text] [PDF]

				M. N. Hylkema, P. J. Sterk, W. I. de Boer, and D. S. Postma Tobacco use in relation to COPD and asthma Eur. Respir. J., March 1, 2007; 29(3): 438 - 445. [Abstract] [Full Text] [PDF]