HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Imamura, R. Articles by Inaba, S. Search for Related Content PubMed PubMed Citation Articles by Imamura, R. Articles by Inaba, S.

Mobilization of Human Lymphoid Progenitors after Treatment with Granulocyte Colony-Stimulating Factor ¹

Rie Imamura^3,*,,, Toshihiro Miyamoto^2,3,, Goichi Yoshimoto, Kenjiro Kamezaki^*,, Fumihiko Ishikawa, Hideho Henzan^*,, Koji Kato, Ken Takase^*,, Akihiko Numata^*,, Koji Nagafuji, Takashi Okamura, Michio Sata, Mine Harada and Shoichi Inaba^4,*

^* Blood Transfusion Service, Kyushu University Hospital, Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, and Second Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan

Hemopoietic stem and progenitor cells ordinarily residing within bone marrow are released into the circulation following G-CSF administration. Such mobilization has a great clinical impact on hemopoietic stem cell transplantation. Underlying mechanisms are incompletely understood, but may involve G-CSF-induced modulation of chemokines, adhesion molecules, and proteolytic enzymes. We studied G-CSF-induced mobilization of CD34⁺CD10⁺CD19^–Lin^– and CD34⁺CD10⁺CD19⁺Lin^– cells (early B and pro-B cells, respectively). These mobilized lymphoid populations could differentiate only into B/NK cells or B cells equivalent to their marrow counterparts. Mobilized lymphoid progenitors expressed lymphoid- but not myeloid-related genes including the G-CSF receptor gene, and displayed the same pattern of Ig rearrangement status as their bone marrow counterparts. Decreased expression of VLA-4 and CXCR-4 on mobilized lymphoid progenitors as well as multipotent and myeloid progenitors indicated lineage-independent involvement of these molecules in G-CSF-induced mobilization. The results suggest that by acting through multiple trans-acting signals, G-CSF can mobilize not only myeloid-committed populations but a variety of resident marrow cell populations including lymphoid progenitors.

This article has been cited by other articles:

				N. Ledee, R. Lombroso, L. Lombardelli, J. Selva, S. Dubanchet, G. Chaouat, F. Frankenne, J.M. Foidart, E. Maggi, S. Romagnani, et al. Cytokines and chemokines in follicular fluids and potential of the corresponding embryo: the role of granulocyte colony-stimulating factor Hum. Reprod., September 1, 2008; 23(9): 2001 - 2009. [Abstract] [Full Text] [PDF]

				U. Mahlknecht and C. Schonbein Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells Haematologica, March 1, 2008; 93(3): 443 - 446. [Abstract] [Full Text] [PDF]

				M. E. Hystad, J. H. Myklebust, T. H. Bo, E. A. Sivertsen, E. Rian, L. Forfang, E. Munthe, A. Rosenwald, M. Chiorazzi, I. Jonassen, et al. Characterization of Early Stages of Human B Cell Development by Gene Expression Profiling J. Immunol., September 15, 2007; 179(6): 3662 - 3671. [Abstract] [Full Text] [PDF]