| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
9V
2 T Cells by NKG2D1
* Institut für Virologie und Immunobiologie,
Medizinische Poliklinik, Julius-Maximilians Universität, Würzburg, Germany;
Institut für Immunologie, Universitätsklinikum Schleswig-Holstein Campus Kiel, Kiel, Germany; and
Institut für Zellbiologie, Eberhard-Karls-Universität Tübingen, Tübingen, Germany
Human V
9V
2 T cells recognize phosphorylated nonpeptide Ags (so called phosphoantigens), certain tumor cells, and cells treated with aminobisphosphonates. NKG2D, an activating receptor for NK cells, has been described as a potent costimulatory receptor in the Ag-specific activation of and CD8 T cells. This study provides evidence that V9V2 T cells may also be directly activated by NKG2D. Culture of PBMC with immobilized NKG2D-specific mAb or NKG2D ligand MHC class I related protein A (MICA) induces the up-regulation of CD69 and CD25 in NK and V9V2 but not in CD8 T cells. Furthermore, NKG2D triggers the production of TNF-
but not of IFN-, as well as the release of cytolytic granules by V9V2 T cells. Purified V9V2 T cells kill MICA-transfected RMA mouse cells but not control cells. Finally, DAP10, which mediates NKG2D signaling in human NK cells, was detected in resting and activated V9V2 T cells. These remarkable similarities in NKG2D function in NK and V9V2 T cells may open new perspectives for V9V2 T cell-based immunotherapy, e.g., by Ag-independent killing of NKG2D ligand-expressing tumors.
This article has been cited by other articles:
|
|
 |
|
  Y. Kong, W. Cao, X. Xi, C. Ma, L. Cui, and W. He The NKG2D ligand ULBP4 binds to TCR{gamma}9/{delta}2 and induces cytotoxicity to tumor cells through both TCR{gamma}{delta} and NKG2D Blood, July 9, 2009; 114(2): 310 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, M. J. Herold, B. Kimmel, I. Muller, B. Rincon-Orozco, V. Kunzmann, and T. Herrmann Reduced Expression of the Mevalonate Pathway Enzyme Farnesyl Pyrophosphate Synthase Unveils Recognition of Tumor Cells by V{gamma}9V{delta}2 T Cells J. Immunol., June 15, 2009; 182(12): 8118 - 8124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Devaud, E. Bilhere, S. Loizon, V. Pitard, C. Behr, J.-F. Moreau, J. Dechanet-Merville, and M. Capone Antitumor Activity of {gamma}{delta} T Cells Reactive against Cytomegalovirus-Infected Cells in a Mouse Xenograft Tumor Model Cancer Res., May 1, 2009; 69(9): 3971 - 3978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Sarikonda, H. Wang, K.-J. Puan, X.-h. Liu, H. K. Lee, Y. Song, M. D. Distefano, E. Oldfield, G. D. Prestwich, and C. T. Morita Photoaffinity Antigens for Human {gamma}{delta} T Cells J. Immunol., December 1, 2008; 181(11): 7738 - 7750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Cao, X. Xi, Z. Wang, L. Dong, Z. Hao, L. Cui, C. Ma, and W. He Four novel ULBP splice variants are ligands for human NKG2D Int. Immunol., August 1, 2008; 20(8): 981 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bessoles, F. Fouret, S. Dudal, G. S. Besra, F. Sanchez, and V. Lafont IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines J. Leukoc. Biol., July 1, 2008; 84(1): 224 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A.Z. Alexander, A. Maniar, J.-S. Cummings, A. M. Hebbeler, D. H. Schulze, B. R. Gastman, C. D. Pauza, S. E. Strome, and A. I. Chapoval Isopentenyl Pyrophosphate-Activated CD56+ {gamma}{delta} T Lymphocytes Display Potent Antitumor Activity toward Human Squamous Cell Carcinoma Clin. Cancer Res., July 1, 2008; 14(13): 4232 - 4240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Cao, X. Xi, Z. Hao, W. Li, Y. Kong, L. Cui, C. Ma, D. Ba, and W. He RAET1E2, a Soluble Isoform of the UL16-binding Protein RAET1E Produced by Tumor Cells, Inhibits NKG2D-mediated NK Cytotoxicity J. Biol. Chem., June 29, 2007; 282(26): 18922 - 18928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Saikali, J. P. Antel, J. Newcombe, Z. Chen, M. Freedman, M. Blain, R. Cayrol, A. Prat, J. A. Hall, and N. Arbour NKG2D-Mediated Cytotoxicity toward Oligodendrocytes Suggests a Mechanism for Tissue Injury in Multiple Sclerosis J. Neurosci., January 31, 2007; 27(5): 1220 - 1228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kabelitz, D. Wesch, and W. He Perspectives of {gamma}{delta} T Cells in Tumor Immunology Cancer Res., January 1, 2007; 67(1): 5 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Caccamo, F. Dieli, D. Wesch, H. Jomaa, and M. Eberl Sex-specific phenotypical and functional differences in peripheral human V{gamma}9/V{delta}2 T cells J. Leukoc. Biol., April 1, 2006; 79(4): 663 - 666. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
