HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Williams, M. A. Articles by Bevan, M. J. Search for Related Content PubMed PubMed Citation Articles by Williams, M. A. Articles by Bevan, M. J.

Cutting Edge: A Single MHC Class Ia Is Sufficient for CD8 Memory T Cell Differentiation ¹

Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195

Recent studies have suggested a role for MHC class Ib molecules in providing signals for memory T cell differentiation during the early phases of acute infection. To test this hypothesis, we assessed the development of effector and memory CD8 T cells in transgenic mice expressing a single chain H-2D^d/₂-microglobulin (₂M) fusion protein on a ₂M-deficient background. These mice thus express a single MHC class Ia in the absence of all other ₂M-dependent class Ia and Ib molecules. Following infection with a recombinant vaccinia virus expressing a known D^d-restricted epitope from HIV-1 gp160, the development of effector and memory cells CD8 T cells was comparable to control mice. Furthermore, these memory cells responded rapidly and robustly to antigenic restimulation. Therefore, we conclude that full CD8 memory differentiation requires only a single MHC class Ia chain, ruling out a requirement for MHC class Ib molecules in this process.

This article has been cited by other articles:

				N. Pardigon, K. Takeda, B. Saunier, F. Hornung, J. Gibbs, A. Weisberg, N. Contractor, B. Kelsall, J. R. Bennink, and J. W. Yewdell CD8{alpha}{alpha}-Mediated Intraepithelial Lymphocyte Snatching of Thymic Leukemia MHC Class Ib Molecules In Vitro and In Vivo J. Immunol., August 1, 2006; 177(3): 1590 - 1598. [Abstract] [Full Text] [PDF]

				A. Jabbari and J. T. Harty The generation and modulation of antigen-specific memory CD8 T cell responses J. Leukoc. Biol., July 1, 2006; 80(1): 16 - 23. [Abstract] [Full Text] [PDF]

				A. Chandele and S. M. Kaech Cutting Edge: Memory CD8 T Cell Maturation Occurs Independently of CD8{alpha}{alpha} J. Immunol., November 1, 2005; 175(9): 5619 - 5623. [Abstract] [Full Text] [PDF]