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2B4/CD48-Mediated Regulation of Lymphocyte Activation and Function ¹

Erika Assarsson^2,*,, Taku Kambayashi, Catrine M. Persson^*, Benedict J. Chambers^* and Hans-Gustaf Ljunggren^2,*

^* Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, San Diego, CA 92122; and Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104

2B4 (CD244) is a member of the CD2 subset of the Ig superfamily. This molecule is expressed on innate immune cells, including NK cells, and on subsets of T cells. The 2B4 molecule interacts with CD48, which is widely expressed on hemopoietic cells. Although earlier reports demonstrated a role for 2B4 as an activating receptor in both mice and humans, recent studies of 2B4-deficient mice have suggested that 2B4 functions predominantly as an inhibitory receptor in mice. In addition, 2B4 may also act as a costimulatory ligand for cells expressing CD48. Thus, the 2B4 molecule is more multifunctional than previously understood. In this study, we delineate the current view of 2B4-CD48 interactions among lymphocytes and other cells.

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