| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,||,||
,||,||
* Department of Neurology and Center for Neurologic Disease and Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115; Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute; Multiple Sclerosis Patient Care and Research Clinic, University of Alberta, Edmonton, Alberta 12201, Canada; ¶ Wadsworth Center, New York State Department of Health, Albany, NY; and || Harvard Medical School, Boston, MA 02115
Autoantibodies to myelin oligodendrocyte glycoprotein (MOG) can induce demyelination and oligodendrocyte loss in models of multiple sclerosis (MS). Whether anti-MOG Abs play a similar role in patients with MS or inflammatory CNS diseases by epitope spreading is unclear. We have therefore examined whether autoantibodies that bind properly folded MOG protein are present in the CNS parenchyma of MS patients. IgG was purified from CNS tissue of 14 postmortem cases of MS and 8 control cases, including cases of encephalitis. Binding was assessed using two independent assays, a fluorescence-based solid-phase assay and a solution-phase RIA. MOG autoantibodies were identified in IgG purified from CNS tissue by solid-phase immunoassay in 7 of 14 cases with MS and 1 case of subacute sclerosing panencephalitis, but not in IgG from noninflamed control tissue. This finding was confirmed with a solution-phase RIA, which measures higher affinity autoantibodies. These data demonstrate that autoantibodies recognizing MOG are present in substantially higher concentrations in the CNS parenchyma compared with cerebrospinal fluid and serum in subjects with MS, indicating that local production/accumulation is an important aspect of autoantibody-mediated pathology in demyelinating CNS diseases. Moreover, chronic inflammatory CNS disease may induce autoantibodies by virtue of epitope spreading.
This article has been cited by other articles:
|
|
 |
|
  M H J Vogt, C E Teunissen, E Iacobaeus, D A M Heijnen, E C W Breij, T Olsson, L Brundin, J Killestein, and C. D Dijkstra Cerebrospinal fluid anti-myelin antibodies are related to magnetic resonance measures of disease activity in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, October 1, 2009; 80(10): 1110 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. McLaughlin, T. Chitnis, J. Newcombe, B. Franz, J. Kennedy, S. McArdel, J. Kuhle, L. Kappos, K. Rostasy, D. Pohl, et al. Age-Dependent B Cell Autoimmunity to a Myelin Surface Antigen in Pediatric Multiple Sclerosis J. Immunol., September 15, 2009; 183(6): 4067 - 4076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Wekerle Lessons from multiple sclerosis: models, concepts, observations Ann Rheum Dis, December 1, 2008; 67(Suppl_3): iii56 - iii60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Breithaupt, B. Schafer, H. Pellkofer, R. Huber, C. Linington, and U. Jacob Demyelinating Myelin Oligodendrocyte Glycoprotein-Specific Autoantibody Response Is Focused on One Dominant Conformational Epitope Region in Rodents J. Immunol., July 15, 2008; 181(2): 1255 - 1263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Hauser, E. Waubant, D. L. Arnold, T. Vollmer, J. Antel, R. J. Fox, A. Bar-Or, M. Panzara, N. Sarkar, S. Agarwal, et al. B-Cell Depletion with Rituximab in Relapsing-Remitting Multiple Sclerosis N. Engl. J. Med., February 14, 2008; 358(7): 676 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
The International Multiple Sclerosis Genetics Cons Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study N. Engl. J. Med., August 30, 2007; 357(9): 851 - 862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kuhle, C. Pohl, M. Mehling, G. Edan, M. S. Freedman, H.-P. Hartung, C. H. Polman, D. H. Miller, X. Montalban, F. Barkhof, et al. Lack of Association between Antimyelin Antibodies and Progression to Multiple Sclerosis N. Engl. J. Med., January 25, 2007; 356(4): 371 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S J Pittock, M Reindl, S Achenbach, T Berger, W Bruck, F Konig, Y Morales, H Lassmann, S Bryant, S B Moore, et al. Myelin oligodendrocyte glycoprotein antibodies in pathologically proven multiple sclerosis: frequency, stability and clinicopathologic correlations Multiple Sclerosis, January 1, 2007; 13(1): 7 - 16. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Zhou, R. Srivastava, S. Nessler, V. Grummel, N. Sommer, W. Bruck, H.-P. Hartung, C. Stadelmann, and B. Hemmer Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis PNAS, December 12, 2006; 103(50): 19057 - 19062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Kim, E. Y. Kim, J. Cerny, and K. D. Moudgil Antibody Responses to Mycobacterial and Self Heat Shock Protein 65 in Autoimmune Arthritis: Epitope Specificity and Implication in Pathogenesis J. Immunol., November 15, 2006; 177(10): 6634 - 6641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Dugas, Y. C. Tai, T. P. Speed, J. Ngai, and B. A. Barres Functional Genomic Analysis of Oligodendrocyte Differentiation J. Neurosci., October 25, 2006; 26(43): 10967 - 10983. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
