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The Journal of Immunology, 2005, 175: 1974-1982.
Copyright © 2005 by The American Association of Immunologists

Antibodies from Inflamed Central Nervous System Tissue Recognize Myelin Oligodendrocyte Glycoprotein1

Kevin C. O’Connor2,*,||, Heiner Appel{ddagger},||, Lisa Bregoli*, Matthew E. Call{ddagger},||, Ingrid Catz§, Jennifer A. Chan{dagger},||, Nicole H. Moore*, Kenneth G. Warren§, Susan J. Wong, David A. Hafler3,*,|| and Kai W. Wucherpfennig3,{ddagger},||

* Department of Neurology and Center for Neurologic Disease and {dagger} Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115; {ddagger} Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute; § Multiple Sclerosis Patient Care and Research Clinic, University of Alberta, Edmonton, Alberta 12201, Canada; Wadsworth Center, New York State Department of Health, Albany, NY; and || Harvard Medical School, Boston, MA 02115

Autoantibodies to myelin oligodendrocyte glycoprotein (MOG) can induce demyelination and oligodendrocyte loss in models of multiple sclerosis (MS). Whether anti-MOG Abs play a similar role in patients with MS or inflammatory CNS diseases by epitope spreading is unclear. We have therefore examined whether autoantibodies that bind properly folded MOG protein are present in the CNS parenchyma of MS patients. IgG was purified from CNS tissue of 14 postmortem cases of MS and 8 control cases, including cases of encephalitis. Binding was assessed using two independent assays, a fluorescence-based solid-phase assay and a solution-phase RIA. MOG autoantibodies were identified in IgG purified from CNS tissue by solid-phase immunoassay in 7 of 14 cases with MS and 1 case of subacute sclerosing panencephalitis, but not in IgG from noninflamed control tissue. This finding was confirmed with a solution-phase RIA, which measures higher affinity autoantibodies. These data demonstrate that autoantibodies recognizing MOG are present in substantially higher concentrations in the CNS parenchyma compared with cerebrospinal fluid and serum in subjects with MS, indicating that local production/accumulation is an important aspect of autoantibody-mediated pathology in demyelinating CNS diseases. Moreover, chronic inflammatory CNS disease may induce autoantibodies by virtue of epitope spreading.




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