| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh PA 15261
The primary goal of this study was to determine how chronic exposure to Ag influences the functionality of Mycobacterium tuberculosis-specific T cell responses. The frequency of IFN-
-producing effector CD4+ and CD8+ T cells dynamically changed during persistent M. tuberculosis infection. CD8+ T cells used differential effector functions during acute and chronic phases of the immune response, where CD8+ T cells produced negligible amounts of IFN- early in infection, but switched to cytokine production during the chronic stage of infection. Using limiting dilution analysis, CD8+ T cells isolated during the initial phase of infection demonstrated lytic potential, but this waned in the chronic stage. The apparent loss of cytotoxic activity was not associated with the lack of perforin. Ag dose could potentially govern the functional program of CD8+ T cells. Collectively, these results depict a host immune response mounted against M. tuberculosis of a significantly more dynamic nature than previously recognized.
This article has been cited by other articles:
|
|
 |
|
  T. Einarsdottir, E. Lockhart, and J. L. Flynn Cytotoxicity and Secretion of Gamma Interferon Are Carried Out by Distinct CD8 T Cells during Mycobacterium tuberculosis Infection Infect. Immun., October 1, 2009; 77(10): 4621 - 4630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. G. Cirillo, S. Subbian, B. Chen, T. R. Weisbrod, W. R. Jacobs Jr., and J. D. Cirillo Protection of Mycobacterium tuberculosis from Reactive Oxygen Species Conferred by the mel2 Locus Impacts Persistence and Dissemination Infect. Immun., June 1, 2009; 77(6): 2557 - 2567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Sharma, P. K. Saha, A. Singh, S. K. Sharma, B. Ghosh, and D. K. Mitra FoxP3+ Regulatory T Cells Suppress Effector T-Cell Function at Pathologic Site in Miliary Tuberculosis Am. J. Respir. Crit. Care Med., June 1, 2009; 179(11): 1061 - 1070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. J. Ray, J. L. Flynn, and D. E. Kirschner Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection J. Immunol., March 15, 2009; 182(6): 3706 - 3717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Dharmadhikari and E. A. Nardell What Animal Models Teach Humans about Tuberculosis Am. J. Respir. Cell Mol. Biol., November 1, 2008; 39(5): 503 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Beamer, D. K. Flaherty, B. D. Assogba, P. Stromberg, M. Gonzalez-Juarrero, R. de Waal Malefyt, B. Vesosky, and J. Turner Interleukin-10 Promotes Mycobacterium tuberculosis Disease Progression in CBA/J Mice J. Immunol., October 15, 2008; 181(8): 5545 - 5550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Gallegos, E. G. Pamer, and M. S. Glickman Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection J. Exp. Med., September 29, 2008; 205(10): 2359 - 2368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Billeskov, C. Vingsbo-Lundberg, P. Andersen, and J. Dietrich Induction of CD8 T Cells against a Novel Epitope in TB10.4: Correlation with Mycobacterial Virulence and the Presence of a Functional Region of Difference-1 J. Immunol., September 15, 2007; 179(6): 3973 - 3981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Scott-Browne, S. Shafiani, G. Tucker-Heard, K. Ishida-Tsubota, J. D. Fontenot, A. Y. Rudensky, M. J. Bevan, and K. B. Urdahl Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis J. Exp. Med., September 3, 2007; 204(9): 2159 - 2169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Ngai, S. McCormick, C. Small, X. Zhang, A. Zganiacz, N. Aoki, and Z. Xing Gamma Interferon Responses of CD4 and CD8 T-Cell Subsets Are Quantitatively Different and Independent of Each Other during Pulmonary Mycobacterium bovis BCG Infection Infect. Immun., May 1, 2007; 75(5): 2244 - 2252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Hogan, E. Heninger, R. A. Elsner, H. A. Vonderheid, P. Hulseberg, D. Co, and M. Sandor Requirements for CD4+ T cell levels in acute Mycobacterium bovis strain bacille Calmette Guerin (BCG)-induced granulomas differ for optimal mycobacterial control versus granuloma formation Int. Immunol., May 1, 2007; 19(5): 627 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Garg, V. Vitvitsky, H. E. Gendelman, and R. Banerjee Monocyte Differentiation, Activation, and Mycobacterial Killing Are Linked to Transsulfuration-dependent Redox Metabolism J. Biol. Chem., December 15, 2006; 281(50): 38712 - 38720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lockhart, A. M. Green, and J. L. Flynn IL-17 Production Is Dominated by {gamma}{delta} T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection J. Immunol., October 1, 2006; 177(7): 4662 - 4669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sud, C. Bigbee, J. L. Flynn, and D. E. Kirschner Contribution of CD8+ T Cells to Control of Mycobacterium tuberculosis Infection J. Immunol., April 1, 2006; 176(7): 4296 - 4314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Carranza, E. Juarez, M. Torres, J. J. Ellner, E. Sada, and S. K. Schwander Mycobacterium tuberculosis Growth Control by Lung Macrophages and CD8 Cells from Patient Contacts Am. J. Respir. Crit. Care Med., January 15, 2006; 173(2): 238 - 245. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
