| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Physiology Program, Harvard School of Public Health, Boston, MA 02115
The macrophage class A scavenger receptors, macrophage receptor with a collagenous structure (MARCO) and type I/II class A scavenger receptor (SR-AI/II), share structural features and roles in host defense, but little is known about their regulation and signaling properties. Ligation of MARCO on mouse thioglycollate-elicited peritoneal macrophages (PEMs) with immobilized mAb costimulated IL-12 production, in contrast to previously reported inhibition by SR-AI/II. PEMs from MARCO-deficient mice exhibited 2.7 times lower IL-12 production in responses to stimulation with LPS and IFN-
and lack of significant IL-12 production on stimulation with LPS alone. Conversely, SR-AI/II-deficient PEMs produced 2.4 and 1.8 times more IL-12 than wild-type PEMs in response to LPS or LPS and IFN-, respectively. Corresponding differences in regulation of SR-A and MARCO expression were also observed. Th1 adjuvants (LPS, a CpG motif-containing oligodeoxynucleotide (CpG-ODN), IL-12, and GM-CSF) increased, whereas Th2-polarizing factors (IL-4, M-CSF, and non-CpG ODN) decreased expression of MARCO on J774 macrophage-like cells. Expression of SR-A was regulated in the opposite manner to MARCO or not affected. Whereas MARCO was involved in opsonin-independent phagocytosis in CpG-ODN-pretreated but not in IL-4-pretreated J774 cells, anti-SR-A Abs inhibited particle uptake in untreated and IL-4-pretreated but not in CpG-ODN-pretreated cells. SR-A and MARCO are regulated differently and mediate distinct negative and positive effects on IL-12 production in macrophages. These differences may contribute to sustained Th1 or Th2 polarization of ongoing immune responses.
This article has been cited by other articles:
|
|
 |
|
  J. C. Todt, B. Hu, and J. L. Curtis The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages J. Leukoc. Biol., August 1, 2008; 84(2): 510 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. V. Limmon, M. Arredouani, K. L. McCann, R. A. C. Minor, L. Kobzik, and F. Imani Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA FASEB J, January 1, 2008; 22(1): 159 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-Y. Wang, J. Facciponte, X. Chen, J. R. Subjeck, and E. A. Repasky Scavenger Receptor-A Negatively Regulates Antitumor Immunity Cancer Res., May 15, 2007; 67(10): 4996 - 5002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Hamilton Jr., S. A. Thakur, J. K. Mayfair, and A. Holian MARCO Mediates Silica Uptake and Toxicity in Alveolar Macrophages from C57BL/6 Mice J. Biol. Chem., November 10, 2006; 281(45): 34218 - 34226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jozefowski, T. H. Sulahian, M. Arredouani, and L. Kobzik Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides J. Leukoc. Biol., October 1, 2006; 80(4): 870 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Arredouani, Z. Yang, A. Imrich, Y. Ning, G. Qin, and L. Kobzik The Macrophage Scavenger Receptor SR-AI/II and Lung Defense against Pneumococci and Particles Am. J. Respir. Cell Mol. Biol., October 1, 2006; 35(4): 474 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Schulert and L.-A. H. Allen Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor J. Leukoc. Biol., September 1, 2006; 80(3): 563 - 571. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
