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The Journal of Immunology, 2005, 175: 7791-7795.
Copyright © 2005 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Lectin-Like Transcript 1 Is a Ligand for the CD161 Receptor1

Hatice Aldemir2,3,*, Virginie Prod’homme2,4,*, Marie-Jeanne Dumaurier*, Christelle Retiere{dagger}, Gwenola Poupon*, Julie Cazareth*, Franck Bihl* and Veronique M. Braud5,*

* Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique/Université de Nice-Sophia Antipolis Unité Mixte de Recherche 6097, Sophia Antipolis, France; and {dagger} Etablissement Francais du Sang, Nantes, France

Human NK cells and subsets of T cells or NKT cells express the orphan C-type lectin receptor CD161 (NKR-P1A) of unknown function. In contrast to rodents that possess several NKR-P1 genes coding for either activating or inhibitory receptors, the nature of signals delivered by the single human NKR-P1A receptor is still to be clarified. In this article, we show that the lectin-like transcript 1 (LLT1) molecule is a ligand for the CD161 receptor. Engagement of CD161 on NK cells with LLT1 expressed on target cells inhibited NK cell-mediated cytotoxicity and IFN-{gamma} secretion. Conversely, LLT1/CD161 interaction in the presence of a TCR signal enhanced IFN-{gamma} production by T cells. These findings identify a novel ligand/receptor pair that differentially regulate NK and T cell functions.




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