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The Journal of Immunology, 2005, 175: 7098-7102.
Copyright © 2005 by The American Association of Immunologists


CUTTING EDGE

Cutting Edge: Murine CD59a Modulates Antiviral CD4+ T Cell Activity in a Complement-Independent Manner1

M. Paula Longhi2, Baalasubramanian Sivasankar, Nader Omidvar, B. Paul Morgan and Awen Gallimore

Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Wales, United Kingdom

CD59 blocks formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex. To investigate a role for CD59 in promoting T cell responses, we compared T cell activation in CD59a-deficient (Cd59a–/–) and wild-type (WT) mice after in vitro stimulation and after infection with rVV. Virus-specific CD4+ T cell responses were significantly enhanced in Cd59a–/– mice compared with WT mice. Similarly, Cd59a–/– T cells responded more vigorously to in vitro stimulation with CD3-specific Abs compared with WT mice. This effect of CD59a on T cell proliferation was found to be complement-independent. Collectively, these results demonstrate that CD59a down-modulates CD4+ T cell activity in vitro and in vivo, thereby revealing another link between complement regulators and T cell activation.




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C. Fang, T. Miwa, H. Shen, and W.-C. Song
Complement-Dependent Enhancement of CD8+ T Cell Immunity to Lymphocytic Choriomeningitis Virus Infection in Decay-Accelerating Factor-Deficient Mice
J. Immunol., September 1, 2007; 179(5): 3178 - 3186.
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