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Cutting Edge: Murine CD59a Modulates Antiviral CD4⁺ T Cell Activity in a Complement-Independent Manner¹

Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Wales, United Kingdom

CD59 blocks formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex. To investigate a role for CD59 in promoting T cell responses, we compared T cell activation in CD59a-deficient (Cd59a^–/–) and wild-type (WT) mice after in vitro stimulation and after infection with rVV. Virus-specific CD4⁺ T cell responses were significantly enhanced in Cd59a^–/– mice compared with WT mice. Similarly, Cd59a^–/– T cells responded more vigorously to in vitro stimulation with CD3-specific Abs compared with WT mice. This effect of CD59a on T cell proliferation was found to be complement-independent. Collectively, these results demonstrate that CD59a down-modulates CD4⁺ T cell activity in vitro and in vivo, thereby revealing another link between complement regulators and T cell activation.

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