| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
Production and Proliferation of CD8+ T Cells1
* Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan;
Faculty of Medicine, Brawijaya University, Malang, East-Java, Indonesia; and
Japan Society for the Promotion of Science, Tokyo, Japan
We recently identified CD8+CD122+ regulatory T cells that directly control CD8+ and CD4+ cells without intervention of APCs. In this study, we investigated the effector mechanism of CD8+CD122+ regulatory T cells by using an in vitro regulation system. The profile of cytokine expression revealed that IL-10 was predominantly produced by CD8+CD122+ cells, whereas other cytokines were similarly expressed in CD8+CD122+ cells and CD8+CD122– cells. Suppression of both proliferation and IFN-
production by CD8+CD122– cells by CD8+CD122+ cells was blocked by adding anti-IL-10 Ab to the culture but not by adding anti-TGF-
Ab. When IL-10 was removed from the conditioned medium from CD8+CD122+ cells, the conditioned medium no longer showed regulatory activity. Finally, CD8+CD122+ cells from IL-10-deficient mice had no regulatory activity in vitro and reduced regulatory activity in vivo. Our results clearly indicate that IL-10 is produced by CD8+CD122+ cells and mediates the regulatory activity of these cells.
This article has been cited by other articles:
|
|
 |
|
  A. Doganci, R. Karwot, J. H. Maxeiner, P. Scholtes, E. Schmitt, M. F. Neurath, H. A. Lehr, I-C. Ho, and S. Finotto IL-2 Receptor {beta}-Chain Signaling Controls Immunosuppressive CD4+ T Cells in the Draining Lymph Nodes and Lung during Allergic Airway Inflammation In Vivo J. Immunol., August 1, 2008; 181(3): 1917 - 1926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rifa'i, Z. Shi, S.-Y. Zhang, Y. H. Lee, H. Shiku, K.-i. Isobe, and H. Suzuki CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-{alpha}{beta}TCR interaction and become IL-10-producing active regulatory cells Int. Immunol., July 1, 2008; 20(7): 937 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Connerotte, A. Van Pel, D. Godelaine, E. Tartour, B. Schuler-Thurner, S. Lucas, K. Thielemans, G. Schuler, and P. G. Coulie Functions of Anti-MAGE T-Cells Induced in Melanoma Patients under Different Vaccination Modalities Cancer Res., May 15, 2008; 68(10): 3931 - 3940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chen, J. J. Priatel, M. T. Chow, and H.-S. Teh Preferential Development of CD4 and CD8 T Regulatory Cells in RasGRP1-Deficient Mice J. Immunol., May 1, 2008; 180(9): 5973 - 5982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Watchmaker, J. A. Urban, E. Berk, Y. Nakamura, R. B. Mailliard, S. C. Watkins, S. M. van Ham, and P. Kalinski Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing J. Immunol., March 15, 2008; 180(6): 3857 - 3865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Lee, Y. Ishida, M. Rifa'i, Z. Shi, K.-i. Isobe, and H. Suzuki Essential Role of CD8+CD122+ Regulatory T Cells in the Recovery from Experimental Autoimmune Encephalomyelitis J. Immunol., January 15, 2008; 180(2): 825 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Saitoh, N. Abiru, M. Nakahara, and Y. Nagayama CD8+CD122+ T Cells, a Newly Identified Regulatory T Subset, Negatively Regulate Graves' Hyperthyroidism in a Murine Model Endocrinology, December 1, 2007; 148(12): 6040 - 6046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fang, V. G. DeMarco, G. C. Sharp, and H. Braley-Mullen Expression of Transgenic FLIP on Thyroid Epithelial Cells Inhibits Induction and Promotes Resolution of Granulomatous Experimental Autoimmune Thyroiditis in CBA/J Mice Endocrinology, December 1, 2007; 148(12): 5734 - 5745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Hubert, N. Jacobs, J.-H. Caberg, J. Boniver, and P. Delvenne The cross-talk between dendritic and regulatory T cells: good or evil? J. Leukoc. Biol., October 1, 2007; 82(4): 781 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Izawa, K. Yamaura, M. J. Albin, M. Jurewicz, K. Tanaka, M. R. Clarkson, T. Ueno, A. Habicht, G. J. Freeman, H. Yagita, et al. A Novel Alloantigen-Specific CD8+PD1+ Regulatory T Cell Induced by ICOS-B7h Blockade In Vivo J. Immunol., July 15, 2007; 179(2): 786 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Billerbeck, H. E. Blum, and R. Thimme Parallel Expansion of Human Virus-Specific FoxP3- Effector Memory and De Novo-Generated FoxP3+ Regulatory CD8+ T Cells upon Antigen Recognition In Vitro J. Immunol., July 15, 2007; 179(2): 1039 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Alatrakchi, C. S. Graham, H. J. J. van der Vliet, K. E. Sherman, M. A. Exley, and M. J. Koziel Hepatitis C Virus (HCV)-Specific CD8+ Cells Produce Transforming Growth Factor {beta} That Can Suppress HCV-Specific T-Cell Responses J. Virol., June 1, 2007; 81(11): 5882 - 5892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Peng, H. Shao, Y. Ke, P. Zhang, G. Han, H. J. Kaplan, and D. Sun Minimally Activated CD8 Autoreactive T Cells Specific for IRBP Express a High Level of Foxp3 and Are Functionally Suppressive Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2178 - 2184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Dobrzanski, J. B. Reome, J. C. Hylind, and K. A. Rewers-Felkins CD8-Mediated Type 1 Antitumor Responses Selectively Modulate Endogenous Differentiated and Nondifferentiated T Cell Localization, Activation, and Function in Progressive Breast Cancer J. Immunol., December 1, 2006; 177(11): 8191 - 8201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Reibke, N. Garbi, R. Ganss, G. J. Hammerling, B. Arnold, and T. Oelert CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen PNAS, October 10, 2006; 103(41): 15142 - 15147. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
