The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vincent, M. S.
Right arrow Articles by Brenner, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vincent, M. S.
Right arrow Articles by Brenner, M. B.
The Journal of Immunology, 2005, 175: 6344-6351.
Copyright © 2005 by The American Association of Immunologists

CD1a-, b-, and c-Restricted TCRs Recognize Both Self and Foreign Antigens1

Michael S. Vincent2, Xiaowei Xiong, Ethan P. Grant, Wei Peng and Michael B. Brenner2

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA 02115

Individual CD1-restricted T cells can recognize either endogenous or foreign lipid Ags, but the extent to which the same CD1-restricted TCR can react to both self and microbial lipids is unknown. In this study, we have identified CD1a-, CD1b-, and CD1c-restricted T cells from normal human donors that induce cytolysis and secrete copious IFN-{gamma} in response to self-CD1 expressed on monocyte-derived dendritic cells. Remarkably, microbial Ags presented by CD1 are even more potent agonists for these same T cells. The {alpha}{beta} T cell receptors from such clones are diverse and confer specificity for both self-CD1 and foreign lipid Ags. The dual reactivity of these CD1-restricted cells suggests that the capacity for rapid responses to inflammatory stimuli without memory coexists with the capacity for strong Ag-specific responses and the generation of memory in vivo.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. M. Russano, G. Bassotti, E. Agea, O. Bistoni, A. Mazzocchi, A. Morelli, S. A. Porcelli, and F. Spinozzi
CD1-Restricted Recognition of Exogenous and Self-Lipid Antigens by Duodenal {gamma}{delta}+ T Lymphocytes
J. Immunol., March 15, 2007; 178(6): 3620 - 3626.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.