HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gruber, A. Articles by Brocker, T. Search for Related Content PubMed PubMed Citation Articles by Gruber, A. Articles by Brocker, T.

MHC Class I-Positive Dendritic Cells (DC) Control CD8 T Cell Homeostasis In Vivo: T Cell Lymphopenia as a Prerequisite for DC-Mediated Homeostatic Proliferation of Naive CD8 T Cells ¹

Institute for Immunology, Ludwig Maximilians University, Munich, Germany

The sizes of peripheral T cell pools are regulated by competition for environmental signals within a given ecological T cell niche. Cytokines and MHC molecules have been identified as resources for which naive T cells compete to proliferate homeostatically in lymphopenic hosts to fill up their respective compartments. However, it still remains unclear to what extent CD4 and CD8 T cells intercompete for these resources and which role dendritic cells (DC) play in this scenario. Using transgenic mice in which only DC express MHC class I, we demonstrate that this type of APC is sufficient to trigger complete homeostatic proliferation of CD8 T cells in vivo. However, normal numbers of endogenous naive CD4 T cells, but not CD25⁺CD4⁺ T regulatory cells, efficiently suppress this expansion in vivo. These findings identify DC as a major resource and a possible target for homeostatic competition between naive CD4 and CD8 T cells.

This article has been cited by other articles:

				J. D. French, C. L. Roark, W. K. Born, and R. L. O'Brien {gamma}{delta} T Lymphocyte Homeostasis Is Negatively Regulated by {beta}2-Microglobulin J. Immunol., February 15, 2009; 182(4): 1892 - 1900. [Abstract] [Full Text] [PDF]

				S. E. Hamilton and S. C. Jameson The nature of the lymphopenic environment dictates protective function of homeostatic-memory CD8+ T cells PNAS, November 25, 2008; 105(47): 18484 - 18489. [Abstract] [Full Text] [PDF]

				D. C. Jay, L. M. Reed-Loisel, and P. E. Jensen Polyclonal MHC Ib-Restricted CD8+ T Cells Undergo Homeostatic Expansion in the Absence of Conventional MHC-Restricted T Cells J. Immunol., March 1, 2008; 180(5): 2805 - 2814. [Abstract] [Full Text] [PDF]

				T. Zaft, A. Sapoznikov, R. Krauthgamer, D. R. Littman, and S. Jung CD11chigh Dendritic Cell Ablation Impairs Lymphopenia-Driven Proliferation of Naive and Memory CD8+ T Cells J. Immunol., November 15, 2005; 175(10): 6428 - 6435. [Abstract] [Full Text] [PDF]