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The Journal of Immunology, 2005, 175: 196-200.
Copyright © 2005 by The American Association of Immunologists

CD8{alpha}+ Dendritic Cells Selectively Present MHC Class I-Restricted Noncytolytic Viral and Intracellular Bacterial Antigens In Vivo1

Gabrielle T. Belz2,*,{dagger}, Ken Shortman*, Michael J. Bevan{ddagger} and William R. Heath*,{dagger}

* Division of Immunology and {dagger} Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia; and {ddagger} Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195

CD8{alpha}+ dendritic cells (DCs) have been shown to be the principal DC subset involved in priming MHC class I-restricted CTL immunity to a variety of cytolytic viruses, including HSV type 1, influenza, and vaccinia virus. Whether priming of CTLs by CD8{alpha}+ DCs is limited to cytolytic viruses, which may provide dead cellular material for this DC subset, or whether these DCs selectively present intracellular Ags, is unknown. To address this question, we examined Ag presentation to a noncytolytic virus, lymphocytic choriomeningitis virus, and to an intracellular bacterium, Listeria monocytogenes. We show that regardless of the type of intracellular infection, CD8{alpha}+ DCs are the principal DC subset that initiate CD8+ T cell immunity.




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