| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of*
Pediatrics, Internal Medicine, Pathology, and Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555; and ¶ Department of Medicine, Baylor College of Medicine, Houston, TX 77030
CD74, or the class II MHC-associated invariant chain, is best known for the regulation of Ag presentation. However, recent studies have suggested other important roles for this protein in inflammation and cancer studies. We have shown that CD74 is expressed on the surface of gastric cells, and Helicobacter pylori can use this receptor as a point of attachment to gastric epithelial cells, which lead to IL-8 production. This study investigates the ability of H. pylori to up-regulate one of its receptors in vivo and with a variety of gastric epithelial cell lines during infection with H. pylori. CD74 expression was increased dramatically on gastric biopsies from H. pylori-positive patients and gastric cell lines exposed to the bacteria. Gastric cells exposed to H. pylori-conditioned medium revealed that the host cell response was responsible for the up-regulation of CD74. IL-8 was found to up-regulate CD74 cell surface expression because blocking IL-8Rs or neutralizing IL-8 with Abs counteracted the increased expression of CD74 observed during infection with H. pylori. These studies demonstrate how H. pylori up-regulates one of its own receptors via an autocrine mechanism involving one of the products induced from host cells.
This article has been cited by other articles:
|
|
 |
|
  J. L. Martin-Ventura, J. Madrigal-Matute, B. Munoz-Garcia, L. M. Blanco-Colio, M. Van Oostrom, G. Zalba, A. Fortuno, C. Gomez-Guerrero, L. Ortega, A. Ortiz, et al. Increased CD74 expression in human atherosclerotic plaques: contribution to inflammatory responses in vascular cells Cardiovasc Res, August 1, 2009; 83(3): 586 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L.W. Wong, S.-L. Zhu, X. R. Huang, J. Ma, H. H.X. Xia, R. Bucala, B. C.Y. Wong, and H. Y. Lan Essential Role for Macrophage Migration Inhibitory Factor in Gastritis Induced by Helicobacter pylori Am. J. Pathol., April 1, 2009; 174(4): 1319 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ye, X. Liu, S. N. Rout, Z. Li, Y. Yan, L. Lu, T. Kamala, N. K. Nanda, W. Song, S. K. Samal, et al. The MHC Class II-Associated Invariant Chain Interacts with the Neonatal Fc{gamma} Receptor and Modulates Its Trafficking to Endosomal/Lysosomal Compartments J. Immunol., August 15, 2008; 181(4): 2572 - 2585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Beswick and V. E. Reyes Macrophage Migration Inhibitory Factor and Interleukin-8 Produced by Gastric Epithelial Cells during Helicobacter pylori Exposure Induce Expression and Activation of the Epidermal Growth Factor Receptor Infect. Immun., July 1, 2008; 76(7): 3233 - 3240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lu, J. Y. Wu, E. J. Beswick, T. Ohno, S. Odenbreit, R. Haas, V. E. Reyes, M. Kita, D. Y. Graham, and Y. Yamaoka Functional and Intracellular Signaling Differences Associated with the Helicobacter pylori AlpAB Adhesin from Western and East Asian Strains J. Biol. Chem., March 2, 2007; 282(9): 6242 - 6254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Beswick, I. V. Pinchuk, G. Suarez, J. C. Sierra, and V. E. Reyes Helicobacter pylori CagA-Dependent Macrophage Migration Inhibitory Factor Produced by Gastric Epithelial Cells Binds to CD74 and Stimulates Procarcinogenic Events. J. Immunol., June 1, 2006; 176(11): 6794 - 6801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Beswick, I. V. Pinchuk, K. Minch, G. Suarez, J. C. Sierra, Y. Yamaoka, and V. E. Reyes The Helicobacter pylori Urease B Subunit Binds to CD74 on Gastric Epithelial Cells and Induces NF-{kappa}B Activation and Interleukin-8 Production Infect. Immun., February 1, 2006; 74(2): 1148 - 1155. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
