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Effects of Increasing IL-7 Availability on Lymphocytes during and after Lymphopenia-Induced Proliferation¹

Nabil Bosco^*, Fabien Agenès^* and Rhodri Ceredig^2,

^* Institut National de la Santé et de la Recherche Médicale Unité 548, Département de Réponse et Dynamique Cellulaire, Commissariat à l’Energie Atomique-G, Grenoble, France; and Institut National de la Santé et de la Recherche Médicale Unité 645, Institut Federatif de Recherche 133, Etablissement Français du Sang, Besançon, France

IL-7 is critically involved in regulating peripheral T cell homeostasis. To investigate the role of IL-7 on lymphopenia-induced proliferation of polyclonal lymphocytes, we have transferred CFSE-labeled cells into a novel T-lymphopenic, IL-7-transgenic mouse line. Results obtained indicate that T and B cells do not respond in the same way to IL-7-homeostatic signals. Overexpression of IL-7 enhances proliferation of both CD4⁺ and CD8⁺ T cells but with distinctly temporal effects. Expansion of naturally arising CD4⁺-regulatory T cells was like that of conventional CD4⁺ T cells. IL-7 had no effect on B cell proliferation. By immunohistology, transferred T cells homed to T cell areas of spleen lymphoid follicles. Increasing IL-7 availability enhanced T cell recovery by promoting cell proliferation and reducing apoptosis during early stages of lymphopenia-induced proliferation. Taken together, these results provide new insights into the pleiotropic effects of IL-7 on lymphopenia-induced T cell proliferation.

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