| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Rheumatology and Inflammation Research,
The Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden; and
Department of Orthopaedics, University Hospital UMAS, University of Lund, Malmö, Sweden
The adipokine resistin is suggested to be an important link between obesity and insulin resistance. In the present study, we assessed the impact of resistin as inflammatogenic cytokine in the setting of arthritis. In vitro experiments on human PBMC were performed to assess cytokine response and transcription pathways of resistin-induced inflammation. Proinflammatory properties of resistin were evaluated in animal model by intra-articular injection of resistin followed by histological evaluation of the joint. Levels of resistin were assessed by ELISA in 74 paired blood and synovial fluid samples of patients with rheumatoid arthritis. Results were compared with the control group comprised blood samples from 34 healthy individuals and 21 synovial fluids from patients with noninflammatory joint diseases. We now show that resistin displays potent proinflammatory properties by 1) strongly up-regulating IL-6 and TNF-
, 2) responding to TNF- challenge, 3) enhancing its own activity by a positive feedback, and finally 4) inducing arthritis when injected into healthy mouse joints. Proinflammatory properties of resistin were abrogated by NF-
B inhibitor indicating the importance of NF-B signaling pathway for resistin-induced inflammation. Resistin is also shown to specifically accumulate in the inflamed joints of patients with rheumatoid arthritis and its levels correlate with other markers of inflammation. Our results indicate that resistin is a new and important member of the cytokine family with potent regulatory functions. Importantly, the identified properties of resistin make it a novel and interesting therapeutic target in chronic inflammatory diseases such as rheumatoid arthritis.
This article has been cited by other articles:
|
|
 |
|
  R. Gomez, F. Lago, J. Gomez-Reino, C. Dieguez, and O. Gualillo Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases J. Mol. Endocrinol., July 1, 2009; 43(1): 11 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Nair, Y. Du, J. G. Perrigoue, C. Zaph, J. J. Taylor, M. Goldschmidt, G. P. Swain, G. D. Yancopoulos, D. M. Valenzuela, A. Murphy, et al. Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung J. Exp. Med., April 13, 2009; 206(4): 937 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H. Chen, Y. Song, E. L. Ding, C. K. Roberts, J. E. Manson, N. Rifai, J. E. Buring, J. M. Gaziano, and S. Liu Circulating Levels of Resistin and Risk of Type 2 Diabetes in Men and Women: Results From Two Prospective Cohorts Diabetes Care, February 1, 2009; 32(2): 329 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Montecucco and F. Mach Common inflammatory mediators orchestrate pathophysiological processes in rheumatoid arthritis and atherosclerosis Rheumatology, January 1, 2009; 48(1): 11 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Qi, J. Wang, H. Li, Z. Yu, X. Ye, F. B Hu, O. H Franco, A. Pan, Y. Liu, and X. Lin Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese Eur. J. Endocrinol., November 1, 2008; 159(5): 585 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Forsblad d'Elia, R. Pullerits, H. Carlsten, and M. Bokarewa Resistin in serum is associated with higher levels of IL-1Ra in post-menopausal women with rheumatoid arthritis Rheumatology, July 1, 2008; 47(7): 1082 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. I. Beier, L. Guo, C. von Montfort, J. P. Kaiser, S. Joshi-Barve, and G. E. Arteel New Role of Resistin in Lipopolysaccharide-Induced Liver Damage in Mice J. Pharmacol. Exp. Ther., June 1, 2008; 325(3): 801 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Cave, R. T. Hurt, T. H. Frazier, P. J. Matheson, R. N. Garrison, C. J. McClain, and S. A. McClave Obesity, Inflammation, and the Potential Application of Pharmaconutrition Nutr Clin Pract, February 1, 2008; 23(1): 16 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Haugen and C. A. Drevon Activation of Nuclear Factor-{kappa}B by High Molecular Weight and Globular Adiponectin Endocrinology, November 1, 2007; 148(11): 5478 - 5486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Tang, Y.-C. Chiu, T.-W. Tan, R.-S. Yang, and W.-M. Fu Adiponectin Enhances IL-6 Production in Human Synovial Fibroblast via an AdipoR1 Receptor, AMPK, p38, and NF-{kappa}B Pathway J. Immunol., October 15, 2007; 179(8): 5483 - 5492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.-W. Wang, H.-F. Hung, H. Chang, P. Kuan, and K.-G. Shyu Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-{alpha} Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2305 - H2312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Ellington, A. R. Malik, G. G. Klee, S. T. Turner, A. D. Rule, T. H. Mosley Jr, and I. J. Kullo Association of Plasma Resistin With Glomerular Filtration Rate and Albuminuria in Hypertensive Adults Hypertension, October 1, 2007; 50(4): 708 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Y. Han, S. Subramanian, C. K. Chan, M. Omer, T. Chiba, T. N. Wight, and A. Chait Adipocyte-Derived Serum Amyloid A3 and Hyaluronan Play a Role in Monocyte Recruitment and Adhesion Diabetes, September 1, 2007; 56(9): 2260 - 2273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Muniyappa, M. Montagnani, K. K. Koh, and M. J. Quon Cardiovascular Actions of Insulin Endocr. Rev., August 1, 2007; 28(5): 463 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Peyrin-Biroulet, M. Chamaillard, F. Gonzalez, E. Beclin, C. Decourcelle, L. Antunes, J. Gay, C. Neut, J.-F. Colombel, and P. Desreumaux Mesenteric fat in Crohn's disease: a pathogenetic hallmark or an innocent bystander? Gut, April 1, 2007; 56(4): 577 - 583. [Full Text] [PDF]
|
|
|
|
 |
|
 L Senolt, D Housa, Z Vernerova, T Jirasek, R Svobodova, D Veigl, K Anderlova, U Muller-Ladner, K Pavelka, and M Haluzik Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum Ann Rheum Dis, April 1, 2007; 66(4): 458 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Majuri, M Santaniemi, K Rautio, A Kunnari, J Vartiainen, A Ruokonen, Y A Kesaniemi, J S Tapanainen, O Ukkola, and L Morin-Papunen Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight women with PCOS: a randomized placebo-controlled study Eur. J. Endocrinol., February 1, 2007; 156(2): 263 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Willemsen, M. van Dijk, Y. B. de Rijke, A. W. van Toorenenbergen, P. G. Mulder, and A. C. Hokken-Koelega Effect of Growth Hormone Therapy on Serum Adiponectin and Resistin Levels in Short, Small-for-Gestational-Age Children and Associations with Cardiovascular Risk Parameters J. Clin. Endocrinol. Metab., January 1, 2007; 92(1): 117 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Kusminski, N. F. da Silva, S. J. Creely, F. M. Fisher, A. L. Harte, A. R. Baker, S. Kumar, and P. G. McTernan The in Vitro Effects of Resistin on the Innate Immune Signaling Pathway in Isolated Human Subcutaneous Adipocytes J. Clin. Endocrinol. Metab., January 1, 2007; 92(1): 270 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Perseghin, G. Lattuada, F. De Cobelli, G. Ntali, A. Esposito, A. Burska, E. Belloni, T. Canu, F. Ragogna, P. Scifo, et al. Serum Resistin and Hepatic Fat Content in Nondiabetic Individuals J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 5122 - 5125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bertolani, P. Sancho-Bru, P. Failli, R. Bataller, S. Aleffi, R. DeFranco, B. Mazzinghi, P. Romagnani, S. Milani, P. Gines, et al. Resistin as an Intrahepatic Cytokine: Overexpression during Chronic Injury and Induction of Proinflammatory Actions in Hepatic Stellate Cells Am. J. Pathol., December 1, 2006; 169(6): 2042 - 2053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Pottie, N Presle, B Terlain, P Netter, D Mainard, and F Berenbaum Obesity and osteoarthritis: more complex than predicted! Ann Rheum Dis, November 1, 2006; 65(11): 1403 - 1405. [Full Text] [PDF]
|
|
|
|
|
|
M Otero, R Lago, R Gomez, F Lago, C Dieguez, J J Gomez-Reino, and O Gualillo Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis Ann Rheum Dis, September 1, 2006; 65(9): 1198 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schaffler, U. Muller-Ladner, J. Scholmerich, and C. Buchler Role of Adipose Tissue as an Inflammatory Organ in Human Diseases Endocr. Rev., August 1, 2006; 27(5): 449 - 467. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tedgui and Z. Mallat Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways Physiol Rev, April 1, 2006; 86(2): 515 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Burlak, A. R. Whitney, D. J. Mead, T. Hackstadt, and F. R. DeLeo Maturation of Human Neutrophil Phagosomes Includes Incorporation of Molecular Chaperones and Endoplasmic Reticulum Quality Control Machinery Mol. Cell. Proteomics, April 1, 2006; 5(4): 620 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ehling, A. Schaffler, H. Herfarth, I. H. Tarner, S. Anders, O. Distler, G. Paul, J. Distler, S. Gay, J. Scholmerich, et al. The Potential of Adiponectin in Driving Arthritis J. Immunol., April 1, 2006; 176(7): 4468 - 4478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. H. Shen, L. Zhang, Y. Gan, X. Wang, J. Wang, S. A. LeMaire, J. S. Coselli, and X. L. Wang Up-regulation of PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome Ten) Mediates p38 MAPK Stress Signal-induced Inhibition of Insulin Signaling: A CROSS-TALK BETWEEN STRESS SIGNALING AND INSULIN SIGNALING IN RESISTIN-TREATED HUMAN ENDOTHELIAL CELLS J. Biol. Chem., March 24, 2006; 281(12): 7727 - 7736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pagano, G. Soardo, C. Pilon, C. Milocco, L. Basan, G. Milan, D. Donnini, D. Faggian, M. Mussap, M. Plebani, et al. Increased Serum Resistin in Nonalcoholic Fatty Liver Disease Is Related to Liver Disease Severity and Not to Insulin Resistance J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 1081 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Arner Editorial: Visfatin--A True Or False Trail To Type 2 Diabetes Mellitus J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 28 - 30. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Herrmann Large meals and large arteries: Is resistin the link? Cardiovasc Res, January 1, 2006; 69(1): 9 - 12. [Full Text] [PDF]
|
|
|
|
|
|
H. S. Jung, K.-H. Park, Y. M. Cho, S. S. Chung, H. J. Cho, S. Y. Cho, S. J. Kim, S. Y. Kim, H. K. Lee, and K. S. Park Resistin is secreted from macrophages in atheromas and promotes atherosclerosis Cardiovasc Res, January 1, 2006; 69(1): 76 - 85. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
