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Receptor-Dependent Genes in Lymph Node and Follicular Dendritic Cell Transcriptomes 1
* Institute of Neuropathology, University Hospital of Zürich, Zürich, Switzerland;
Institute of Human Histology, University of Liège, Liège, Belgium;
School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia; and
Department of Pathology, University of Chicago, Chicago, IL 60637
Affinity maturation and Ab class switches occur in lymphoid germinal centers (GCs), in which differentiation and maintenance depend on lymphotoxin (LT) signaling and include differentiation of follicular dendritic cells (FDCs). The events leading to FDC and GC maturation are poorly defined. Using several approaches of functional genomics, we enumerated transcripts affected in mice by suppressing LT 
receptor (LTR) signaling and/or overrepresented in FDC-enriched GC isolates. Protein expression analysis of 3 of 12 genes both enriched in FDCs and down-regulated by LTR signaling suppression validated them as FDC markers. Functional analysis of one of these three, clusterin, suggests a role as an FDC-derived trophic factor for GC B cells. Hence, the set of genes presented in this study includes markers emanating from LTR signaling and transcripts relevant to GC and FDC function.
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