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Cutting Edge: In Vivo Blockade of Human IL-2 Receptor Induces Expansion of CD56^bright Regulatory NK Cells in Patients with Active Uveitis

Zhuqing Li^*, Wee Kiak Lim^1,*,, Sankaranarayana P. Mahesh^*, Baoying Liu^* and Robert B. Nussenblatt^2,*

^* Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892; and Singapore National Eye Center, Singapore

In vivo blockade of the human IL-2R by mAb has been used for immunosuppression in transplantation, therapy for leukemia, and autoimmune diseases. In this study, we report that administration of a humanized IL-2R blocking Ab induced a 4- to 20-fold expansion of CD56^bright regulatory NK cells in uveitis patients over time. The induced CD56^bright regulatory NK cells from patients exhibited similar phenotype as those naturally occurring CD56^bright cells. Patients with active uveitis had a significantly lower level of CD56^bright NK cells compared with normal donors (p < 0.01). In addition, the induced CD56^bright cells could secrete large amounts of IL-10 whereas CD56^dim NK cells could not, suggesting that the induction of the CD56^bright cells may have a beneficial effect on the remission of active uveitis. Our observation may have implications to IL-2R blockade therapy and for the potential role of CD56^bright regulatory NK cells in autoimmune diseases.

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Cutting edge: in vivo blockade of human IL-2 receptor induces expansion of CD56^bright regulatory NK cells in patients with active uveitis

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The JI 2005 175: 3447. [Full Text]  

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