| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206; and Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Charlestown, MA 02129
Recent studies in both human and rodents have indicated that in addition to CD4+ T cells, CD8+ T cells play an important role in allergic inflammation. We previously demonstrated that allergen-sensitized and -challenged CD8-deficient (CD8–/–) mice develop significantly lower airway hyperresponsiveness (AHR), eosinophilic inflammation, and IL-13 levels in bronchoalveolar lavage fluid compared with wild-type mice, and that all these responses were restored by adoptive transfer of in vivo-primed CD8+ T cells or in vitro-generated effector CD8+ T cells (TEFF). Recently, leukotriene B4 and its high affinity receptor, BLT1, have been shown to mediate in vitro-generated TEFF recruitment into inflamed tissues. In this study we investigated whether BLT1 is essential for the development of CD8+ T cell-mediated allergic AHR and inflammation. Adoptive transfer of in vivo-primed BLT1+/+, but not BLT1–/–, CD8+ T cells into sensitized and challenged CD8–/– mice restored AHR, eosinophilic inflammation, and IL-13 levels. Moreover, when adoptively transferred into sensitized CD8–/– mice, in vitro-generated BLT1+/+, but not BLT1–/–, TEFF accumulated in the lung and mediated these altered airway responses to allergen challenge. These data are the first to show both a functional and an essential role for BLT1 in allergen-mediated CD8+ TEFF recruitment into the lung and development of AHR and airway inflammation.
This article has been cited by other articles:
|
|
 |
|
  N. Miyahara, H. Ohnishi, H. Matsuda, S. Miyahara, K. Takeda, T. Koya, S. Matsubara, M. Okamoto, A. Dakhama, B. Haribabu, et al. Leukotriene B4 Receptor 1 Expression on Dendritic Cells Is Required for the Development of Th2 Responses and Allergen-Induced Airway Hyperresponsiveness J. Immunol., July 15, 2008; 181(2): 1170 - 1178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Joetham, S. Matsubara, M. Okamoto, K. Takeda, N. Miyahara, A. Dakhama, and E. W. Gelfand Plasticity of Regulatory T Cells: Subversion of Suppressive Function and Conversion to Enhancement of Lung Allergic Responses J. Immunol., June 1, 2008; 180(11): 7117 - 7124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Okamoto, K. Takeda, A. Joetham, H. Ohnishi, H. Matsuda, C. H. Swasey, B. J. Swanson, K. Yasutomo, A. Dakhama, and E. W. Gelfand Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation J. Exp. Med., May 12, 2008; 205(5): 1087 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. Henderson Jr., E. Y. Chi, J. G. Bollinger, Y.-t. Tien, X. Ye, L. Castelli, Y. P. Rubtsov, A. G. Singer, G. K.S. Chiang, T. Nevalainen, et al. Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model J. Exp. Med., April 16, 2007; 204(4): 865 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Liao, Y. Ke, W.-H. Shao, B. Haribabu, H. J. Kaplan, D. Sun, and H. Shao Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis. Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1543 - 1549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Taube, N. Miyahara, V. Ott, B. Swanson, K. Takeda, J. Loader, L. D. Shultz, A. M. Tager, A. D. Luster, A. Dakhama, et al. The Leukotriene B4 Receptor (BLT1) Is Required for Effector CD8+ T Cell-Mediated, Mast Cell-Dependent Airway Hyperresponsiveness. J. Immunol., March 1, 2006; 176(5): 3157 - 3164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Matsubara, G. Li, K. Takeda, J. E. Loader, P. Pine, E. S. Masuda, N. Miyahara, S. Miyahara, J. J. Lucas, A. Dakhama, et al. Inhibition of Spleen Tyrosine Kinase Prevents Mast Cell Activation and Airway Hyperresponsiveness Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 56 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. D. Medoff, A. M. Tager, R. Jackobek, T. K. Means, L. Wang, and A. D. Luster Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1 Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L170 - L178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Peebles Jr, K. Hashimoto, J. R. Sheller, M. L. Moore, J. D. Morrow, S. Ji, J. A. Elias, K. Goleniewska, J. O'Neal, D. B. Mitchell, et al. Allergen-Induced Airway Hyperresponsiveness Mediated by Cyclooxygenase Inhibition Is Not Dependent on 5-Lipoxygenase or IL-5, but Is IL-13 Dependent J. Immunol., December 15, 2005; 175(12): 8253 - 8259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Terawaki, T. Yokomizo, T. Nagase, A. Toda, M. Taniguchi, K. Hashizume, T. Yagi, and T. Shimizu Absence of Leukotriene B4 Receptor 1 Confers Resistance to Airway Hyperresponsiveness and Th2-Type Immune Responses J. Immunol., October 1, 2005; 175(7): 4217 - 4225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Okuno, T. Yokomizo, T. Hori, M. Miyano, and T. Shimizu Leukotriene B4 Receptor and the Function of Its Helix 8 J. Biol. Chem., September 16, 2005; 280(37): 32049 - 32052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Miyahara, K. Takeda, S. Miyahara, S. Matsubara, T. Koya, A. Joetham, E. Krishnan, A. Dakhama, B. Haribabu, and E. W. Gelfand Requirement for Leukotriene B4 Receptor 1 in Allergen-induced Airway Hyperresponsiveness Am. J. Respir. Crit. Care Med., July 15, 2005; 172(2): 161 - 167. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
