| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-Defensin Expression in Human Skin by Microbial Stimuli1
Host Defense Laboratory, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095
In response to infection, epithelia mount an innate immune response that includes the production of antimicrobial peptides. However, the pathways that connect infection and inflammation with the induction of antimicrobial peptides in epithelia are not understood. We analyzed the molecular links between infection and the expression of three antimicrobial peptides of the 
-defensin family, human -defensin (hBD)-1, hBD-2, and hBD-3 in the human epidermis. After exposure to microbe-derived molecules, both monocytes and lymphocytes stimulated the epidermal expression of hBD-1, hBD-2, and hBD-3. The induced expression of hBD-3 was mediated by transactivation of the epidermal growth factor receptor. The mechanisms of induction of hBD-1 and hBD-3 were distinct from each other and from the IL-1-dependent induction of hBD-2 expression. Thus during inflammation, epidermal expression of -defensins is mediated by at least three different mechanisms.
This article has been cited by other articles:
|
|
 |
|
  P. Presicce, S. Giannelli, A. Taddeo, M. L. Villa, and S. Della Bella Human defensins activate monocyte-derived dendritic cells, promote the production of proinflammatory cytokines, and up-regulate the surface expression of CD91 J. Leukoc. Biol., October 1, 2009; 86(4): 941 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.Q. Lin, J.Y. Li, H.Y. Wang, J. Liu, C.L. Zhang, W.T. Wang, J. Liu, N. Li, and S.H. Jin Cloning and identification of a novel sperm binding protein, HEL-75, with antibacterial activity and expressed in the human epididymis Hum. Reprod., September 1, 2008; 23(9): 2086 - 2094. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Koff, M. X. G. Shao, I. F. Ueki, and J. A. Nadel Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium Am J Physiol Lung Cell Mol Physiol, June 1, 2008; 294(6): L1068 - L1075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Sperandio, B. Regnault, J. Guo, Z. Zhang, S. L. Stanley Jr., P. J. Sansonetti, and T. Pedron Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression J. Exp. Med., May 12, 2008; 205(5): 1121 - 1132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hinrichsen, R. Podschun, S. Schubert, J. M. Schroder, J. Harder, and E. Proksch Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3 Antimicrob. Agents Chemother., May 1, 2008; 52(5): 1876 - 1879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Taylor, D. J. Clarke, B. McCullough, W. Chin, E. Seo, D. Yang, J. Oppenheim, D. Uhrin, J. R. W. Govan, D. J. Campopiano, et al. Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of {beta}-Defensin 3 J. Biol. Chem., March 14, 2008; 283(11): 6631 - 6639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Harder, R. Glaser, and J.-M. Schroder Review: Human antimicrobial proteins effectors of innate immunity Innate Immunity, December 1, 2007; 13(6): 317 - 338. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Funderburg, M. M. Lederman, Z. Feng, M. G. Drage, J. Jadlowsky, C. V. Harding, A. Weinberg, and S. F. Sieg Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2 PNAS, November 20, 2007; 104(47): 18631 - 18635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Hubert, L. Herman, C. Maillard, J.-H. Caberg, A. Nikkels, G. Pierard, J.-M. Foidart, A. Noel, J. Boniver, and P. Delvenne Defensins induce the recruitment of dendritic cells in cervical human papillomavirus-associated (pre)neoplastic lesions formed in vitro and transplanted in vivo FASEB J, September 1, 2007; 21(11): 2765 - 2775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Koff, M. X. G. Shao, S. Kim, I. F. Ueki, and J. A. Nadel Pseudomonas Lipopolysaccharide Accelerates Wound Repair via Activation of a Novel Epithelial Cell Signaling Cascade J. Immunol., December 15, 2006; 177(12): 8693 - 8700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Huang, W. Du, S. A. McClellan, R. P. Barrett, and L. D. Hazlett TLR4 Is Required for Host Resistance in Pseudomonas aeruginosa Keratitis Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 4910 - 4916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Q. Sun, R. Arnold, C. Fernandez-Golarz, A. B. Parrish, T. Almekinder, J. He, S.-m. Ho, P. Svoboda, J. Pohl, F. F. Marshall, et al. Human {beta}-Defensin-1, a Potential Chromosome 8p Tumor Suppressor: Control of Transcription and Induction of Apoptosis in Renal Cell Carcinoma. Cancer Res., September 1, 2006; 66(17): 8542 - 8549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Boughan, R. H. Argent, M. Body-Malapel, J.-H. Park, K. E. Ewings, A. G. Bowie, S. J. Ong, S. J. Cook, O. E. Sorensen, B. A. Manzo, et al. Nucleotide-binding Oligomerization Domain-1 and Epidermal Growth Factor Receptor: CRITICAL REGULATORS OF beta-DEFENSINS DURING HELICOBACTER PYLORI INFECTION J. Biol. Chem., April 28, 2006; 281(17): 11637 - 11648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Voss, J. Wehkamp, K. Wehkamp, E. F. Stange, J. M. Schroder, and J. Harder NOD2/CARD15 Mediates Induction of the Antimicrobial Peptide Human Beta-defensin-2 J. Biol. Chem., January 27, 2006; 281(4): 2005 - 2011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zilbauer, N. Dorrell, P. K. Boughan, A. Harris, B. W. Wren, N. J. Klein, and M. Bajaj-Elliott Intestinal Innate Immunity to Campylobacter jejuni Results in Induction of Bactericidal Human Beta-Defensins 2 and 3 Infect. Immun., November 1, 2005; 73(11): 7281 - 7289. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
