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T Cell Homeostasis Is Controlled by IL-7 and IL-15 Together with Subset-Specific Factors¹

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037

Among T cell subsets, T cells uniquely display an Ag receptor-based tissue distribution, but what defines their preferential homing and homeostasis is unknown. To address this question, we studied the resources that control T cell homeostasis in secondary lymphoid organs. We found that and T cells are controlled by partially overlapping resources, because acute homeostatic proliferation of T cells was inhibited by an intact T cell compartment, and both populations were dependent on IL-7 and IL-15. Significantly, to undergo acute homeostatic proliferation, T cells also required their own depletion. Thus, T cell homeostasis is maintained by trophic cytokines commonly used by other types of lymphoid cells, as well as by additional, as yet unidentified, -specific factors.

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