| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Immunology, Weizmann Institute of Science, Rehovot, Israel;
Department of Gastroenterology, E. Wolfson Medical Center, Holon, Israel; and
Department of Internal Medicine D, Assaf Harofe, Zerifin, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Extracellular heat shock protein 60 (HSP60) has been considered a proinflammatory danger signal. Yet, HSP60 can also down-regulate experimental immune arthritis and diabetes models by specific inhibition of Th1-like responses. We now report that HSP60 in vitro differentially modulates the expression of Th1/Th2 transcription factors in human T cells: HSP60 down-regulates T-bet, NF-
B, and NFATp and up-regulates GATA-3, leading to decreased secretion of TNF-
and IFN-
and enhanced secretion of IL-10. These effects depended on TLR2 signaling and could not be attributed to LPS or to other contaminants. In BALB/c mice, HSP60 in vivo inhibited the clinical, histological, and serological manifestations of Con A-induced hepatitis associated with up-regulated T cell expression of suppressor of cytokine signaling 3 and GATA-3 and down-regulated T-bet expression. These results provide a molecular explanation for the effects of HSP60 treatment on T cell inflammation via innate regulation of the inflammatory response.
This article has been cited by other articles:
|
|
 |
|
  M. Bevelander, J. Mayette, L. A. Whittaker, S. A. Paveglio, C. C. Jones, J. Robbins, D. Hemenway, S. Akira, S. Uematsu, and M. E. Poynter Nitrogen Dioxide Promotes Allergic Sensitization to Inhaled Antigen J. Immunol., September 15, 2007; 179(6): 3680 - 3688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zanin-Zhorov, G. Tal-Lapidot, L. Cahalon, M. Cohen-Sfady, M. Pevsner-Fischer, O. Lider, and I. R. Cohen Cutting Edge: T Cells Respond to Lipopolysaccharide Innately via TLR4 Signaling J. Immunol., July 1, 2007; 179(1): 41 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Shamaei-Tousi, J. P. Halcox, and B. Henderson Stressing the obvious? Cell stress and cell stress proteins in cardiovascular disease Cardiovasc Res, April 1, 2007; 74(1): 19 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Hauet-Broere, L Wieten, T Guichelaar, S Berlo, R van der Zee, and W Van Eden Heat shock proteins induce T cell regulation of chronic inflammation Ann Rheum Dis, November 1, 2006; 65(suppl_3): iii65 - iii68. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Nussbaum, A. Zanin-Zhorov, F. Quintana, O. Lider, and I. R. Cohen Peptide p277 of HSP60 signals T cells: inhibition of inflammatory chemotaxis Int. Immunol., October 1, 2006; 18(10): 1413 - 1419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cohen-Sfady, G. Nussbaum, M. Pevsner-Fischer, F. Mor, P. Carmi, A. Zanin-Zhorov, O. Lider, and I. R. Cohen Heat Shock Protein 60 Activates B Cells via the TLR4-MyD88 Pathway J. Immunol., September 15, 2005; 175(6): 3594 - 3602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Quintana and I. R. Cohen Heat Shock Proteins as Endogenous Adjuvants in Sterile and Septic Inflammation J. Immunol., September 1, 2005; 175(5): 2777 - 2782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zanin-Zhorov, G. Tal, S. Shivtiel, M. Cohen, T. Lapidot, G. Nussbaum, R. Margalit, I. R. Cohen, and O. Lider Heat Shock Protein 60 Activates Cytokine-Associated Negative Regulator Suppressor of Cytokine Signaling 3 in T Cells: Effects on Signaling, Chemotaxis, and Inflammation J. Immunol., July 1, 2005; 175(1): 276 - 285. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
