The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow A correction has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Related articles in The JI
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stuart, L. M.
Right arrow Articles by Ezekowitz, R. A. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stuart, L. M.
Right arrow Articles by Ezekowitz, R. A. B.
The Journal of Immunology, 2005, 174: 3220-3226.
Copyright © 2005 by The American Association of Immunologists

Mannose-Binding Lectin-Deficient Mice Display Defective Apoptotic Cell Clearance but No Autoimmune Phenotype1

Lynda M. Stuart2,3,*,{dagger}, Kazue Takahashi2,*, Lei Shi*, John Savill{dagger} and R. Alan B. Ezekowitz*

* Laboratory of Developmental Immunology, Harvard Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114; and {dagger} Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom

Mannose-binding lectin (MBL) is a circulating serum protein that is sequestered to sites of inflammation and infection. MBL is a member of the collectin family with structural similarities to the lung collectins and functional similarities to C1q. Both MBL and C1q activate complement; C1q activates the classical pathway and MBL the lectin pathway. Here we demonstrate that MBL binds apoptotic cells in vitro and confirm a role for MBL in clearance of apoptotic cells in vivo. Despite MBL null mice demonstrating defective apoptotic cell clearance they did not develop spontaneous autoimmunity, lymphoproliferation, or germinal center expansion although increased numbers of peritoneal B1 cells were detected. These data demonstrate an important in vivo role for MBL in clearance of dying cells and adds the MBL null animals to the few animals with demonstrable in vivo apoptotic cell clearance defects. Moreover, it demonstrates that failure of apoptotic cell clearance can be dissociated from autoimmunity.


Related articles in The JI:

Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype
L. M. Stuart, K. Takahashi, L. Shi, J. Savill, and R. A. B. Ezekowitz
The JI 2005 175: 3447. [Full Text]  



This article has been cited by other articles:


Home page
 J. Immunol.Home page
D. A. Fraser, A. K. Laust, E. L. Nelson, and A. J. Tenner
C1q Differentially Modulates Phagocytosis and Cytokine Responses during Ingestion of Apoptotic Cells by Human Monocytes, Macrophages, and Dendritic Cells
J. Immunol., November 15, 2009; 183(10): 6175 - 6185.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
V. W.Y. Leung, S. Yun, M. Botto, J. C. Mason, T. H. Malik, W. Song, D. Paixao-Cavalcante, M. C. Pickering, J. J. Boyle, and D. O. Haskard
Decay-Accelerating Factor Suppresses Complement C3 Activation and Retards Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice
Am. J. Pathol., October 1, 2009; 175(4): 1757 - 1767.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Chen, S. Khanna, C. S. Goodyear, Y. B. Park, E. Raz, S. Thiel, C. Gronwall, J. Vas, D. L. Boyle, M. Corr, et al.
Regulation of Dendritic Cells and Macrophages by an Anti-Apoptotic Cell Natural Antibody that Suppresses TLR Responses and Inhibits Inflammatory Arthritis
J. Immunol., July 15, 2009; 183(2): 1346 - 1359.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
O. B. Christiansen, H. S. Nielsen, M. Lund, R. Steffensen, and K. Varming
Mannose-binding lectin-2 genotypes and recurrent late pregnancy losses
Hum. Reprod., February 1, 2009; 24(2): 291 - 299.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Hemmi, J. Idoyaga, K. Suda, N. Suda, K. Kennedy, M. Noda, A. Aderem, and R. M. Steinman
A New Triggering Receptor Expressed on Myeloid Cells (Trem) Family Member, Trem-Like 4, Binds to Dead Cells and Is a DNAX Activation Protein 12-Linked Marker for Subsets of Mouse Macrophages and Dendritic Cells
J. Immunol., February 1, 2009; 182(3): 1278 - 1286.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
M. Ramos-Casals, P. Brito-Zeron, N. Soria, N. Nardi, A. Vargas, S. Munoz, A. Bove, B. Suarez, and F. Lozano
Mannose-binding lectin-low genotypes are associated with milder systemic and immunological disease expression in primary Sjogren's syndrome
Rheumatology, January 1, 2009; 48(1): 65 - 69.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. P. Lillis, M. C. Greenlee, I. Mikhailenko, S. V. Pizzo, A. J. Tenner, D. K. Strickland, and S. S. Bohlson
Murine Low-Density Lipoprotein Receptor-Related Protein 1 (LRP) Is Required for Phagocytosis of Targets Bearing LRP Ligands but Is Not Required for C1q-Triggered Enhancement of Phagocytosis
J. Immunol., July 1, 2008; 181(1): 364 - 373.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L.-P. Erwig and P. M. Henson
Immunological Consequences of Apoptotic Cell Phagocytosis
Am. J. Pathol., July 1, 2007; 171(1): 2 - 8.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Carter, M. Sumiya, K. Reilly, R. Ahmed, P. Sobieszczuk, J. A. Summerfield, and R. A. Lawrence
Mannose-Binding Lectin A-Deficient Mice Have Abrogated Antigen-Specific IgM Responses and Increased Susceptibility to a Nematode Infection
J. Immunol., April 15, 2007; 178(8): 5116 - 5123.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
F.E. van de Geijn, A. Roos, Y.A. de Man, J.D. Laman, C.J.M. de Groot, M.R. Daha, J.M.W. Hazes, and R.J.E.M. Dolhain
Mannose-binding lectin levels during pregnancy: a longitudinal study
Hum. Reprod., February 1, 2007; 22(2): 362 - 371.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
V. K. Bhatia, S. Yun, V. Leung, D. C. Grimsditch, G. M. Benson, M. B. Botto, J. J. Boyle, and D. O. Haskard
Complement C1q Reduces Early Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice
Am. J. Pathol., January 1, 2007; 170(1): 416 - 426.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. S. Levine, R. Subang, S. H. Nasr, S. Fournier, G. Lajoie, J. Wither, and J. Rauch
Immunization with an Apoptotic Cell-Binding Protein Recapitulates the Nephritis and Sequential Autoantibody Emergence of Systemic Lupus Erythematosus
J. Immunol., November 1, 2006; 177(9): 6504 - 6516.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
S Saevarsdottir, H Kristjansdottir, G Grondal, T Vikingsdottir, K Steinsson, and H Valdimarsson
Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosus
Ann Rheum Dis, November 1, 2006; 65(11): 1462 - 1467.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Zhang, K. Takahashi, E. M. Alicot, T. Vorup-Jensen, B. Kessler, S. Thiel, J. C. Jensenius, R. A. B. Ezekowitz, F. D. Moore, and M. C. Carroll
Activation of the Lectin Pathway by Natural IgM in a Model of Ischemia/Reperfusion Injury
J. Immunol., October 1, 2006; 177(7): 4727 - 4734.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Lucas, L. M. Stuart, A. Zhang, K. Hodivala-Dilke, M. Febbraio, R. Silverstein, J. Savill, and A. Lacy-Hulbert
Requirements for Apoptotic Cell Contact in Regulation of Macrophage Responses
J. Immunol., September 15, 2006; 177(6): 4047 - 4054.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
D. A. Fraser, S. S. Bohlson, N. Jasinskiene, N. Rawal, G. Palmarini, S. Ruiz, R. Rochford, and A. J. Tenner
C1q and MBL, components of the innate immune system, influence monocyte cytokine expression
J. Leukoc. Biol., July 1, 2006; 80(1): 107 - 116.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. A. Patel, A. Longacre, K. Hsiao, H. Fan, F. Meng, J. E. Mitchell, J. Rauch, D. S. Ucker, and J. S. Levine
Apoptotic Cells, at All Stages of the Death Process, Trigger Characteristic Signaling Events That Are Divergent from and Dominant over Those Triggered by Necrotic Cells: IMPLICATIONS FOR THE DELAYED CLEARANCE MODEL OF AUTOIMMUNITY
J. Biol. Chem., February 24, 2006; 281(8): 4663 - 4670.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Moller-Kristensen, W. K. E. Ip, L. Shi, L. D. Gowda, M. R. Hamblin, S. Thiel, J. Chr. Jensenius, R. A. B. Ezekowitz, and K. Takahashi
Deficiency of Mannose-Binding Lectin Greatly Increases Susceptibility to Postburn Infection with Pseudomonas aeruginosa
J. Immunol., February 1, 2006; 176(3): 1769 - 1775.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Takahashi, L. Shi, L. D. Gowda, and R. A. B. Ezekowitz
Relative Roles of Complement Factor 3 and Mannose-Binding Lectin in Host Defense against Infection
Infect. Immun., December 1, 2005; 73(12): 8188 - 8193.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. C. Walsh, T. Bourcier, K. Takahashi, L. Shi, M. N. Busche, R. P. Rother, S. D. Solomon, R. A. B. Ezekowitz, and G. L. Stahl
Mannose-Binding Lectin Is a Regulator of Inflammation That Accompanies Myocardial Ischemia and Reperfusion Injury
J. Immunol., July 1, 2005; 175(1): 541 - 546.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.