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The Journal of Immunology, 2005, 174: 3137-3142.
Copyright © 2005 by The American Association of Immunologists

BRIEF REVIEWS

Leptin in Immunology1

Giuseppe Matarese2,3,*, Stergios Moschos2,{dagger} and Christos S. Mantzoros3,{ddagger}

* Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimenttale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli, Italy; {dagger} Department of Medicine, Division of Hematology/Oncology, Pittsburgh Cancer Institute, Pittsburgh, PA 15232; and {ddagger} Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215

Leptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. As a cytokine, leptin also affects thymic homeostasis and, similar to other proinflammatory cytokines, leptin promotes Th1 cell differentiation and cytokine production. We review herein recent advances on the role of leptin in the pathophysiology of immune responses.




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