| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
via Autocrine IL-121
Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021
We have isolated rare cells bearing the NK cell surface marker NK1.1, as well as the dendritic cell (DC) marker CD11c, from the spleen, liver, lymph nodes, and thymus of normal mice. These cells possess both NK cell and DC function because they can lyse tumor cells and subsequently present Ags to naive Ag-specific T cells. Interestingly, in response to IL-4 plus either IL-2 or CpG, NKDC produce more IFN-
than do DC, or even NK cells. We determined that CpG, but not IL-2, induces NKDC to secrete IFN- via the autocrine effects of IL-12. In vivo, CpG dramatically increases the number of NKDC. Furthermore, NKDC induce greater Ag-specific T cell activation than do DC after adoptive transfer. Their unique ability to lyse tumor cells, present Ags, and secrete inflammatory cytokines suggests that NKDC may play a crucial role in linking innate and adaptive immunity.
This article has been cited by other articles:
|
|
 |
|
  C. Chauvin, J.-M. Philippeau, C. Hemont, F.-X. Hubert, Y. Wittrant, F. Lamoureux, B. Trinite, D. Heymann, F. Redini, and R. Josien Killer Dendritic Cells Link Innate and Adaptive Immunity against Established Osteosarcoma in Rats Cancer Res., November 15, 2008; 68(22): 9433 - 9440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Welner, R. Pelayo, Y. Nagai, K. P. Garrett, T. R. Wuest, D. J. Carr, L. A. Borghesi, M. A. Farrar, and P. W. Kincade Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection Blood, November 1, 2008; 112(9): 3753 - 3761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Burt, G. Plitas, J. A. Stableford, H. M. Nguyen, Z. M. Bamboat, V. G. Pillarisetty, and R. P. DeMatteo CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis J. Leukoc. Biol., October 1, 2008; 84(4): 1039 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. P. Nishimoto, A. K. Laust, and E. L. Nelson A Human Dendritic Cell Subset Receptive to the Venezuelan Equine Encephalitis Virus-Derived Replicon Particle Constitutively Expresses IL-32 J. Immunol., September 15, 2008; 181(6): 4010 - 4018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chauvin and R. Josien Dendritic Cells as Killers: Mechanistic Aspects and Potential Roles J. Immunol., July 1, 2008; 181(1): 11 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cook, N. Miyahara, N. Jin, J. M. Wands, C. Taube, C. L. Roark, T. A. Potter, E. W. Gelfand, R. L. O'Brien, and W. K. Born Evidence That CD8+ Dendritic Cells Enable the Development of {gamma}{delta} T Cells That Modulate Airway Hyperresponsiveness J. Immunol., July 1, 2008; 181(1): 309 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ullrich, M. Bonmort, G. Mignot, B. Jacobs, D. Bosisio, S. Sozzani, A. Jalil, F. Louache, E. Bulanova, F. Geissman, et al. Trans-Presentation of IL-15 Dictates IFN-Producing Killer Dendritic Cells Effector Functions J. Immunol., June 15, 2008; 180(12): 7887 - 7897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Pilbeam, P. Basse, L. Brossay, N. Vujanovic, R. Gerstein, A. N. Vallejo, and L. Borghesi The Ontogeny and Fate of NK Cells Marked by Permanent DNA Rearrangements J. Immunol., February 1, 2008; 180(3): 1432 - 1441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. McAleer, D. J. Zammit, L. Lefrancois, R. J. Rossi, and A. T. Vella The Lipopolysaccharide Adjuvant Effect on T Cells Relies on Nonoverlapping Contributions from the MyD88 Pathway and CD11c+ Cells J. Immunol., November 15, 2007; 179(10): 6524 - 6535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Caminschi, F. Ahmet, K. Heger, J. Brady, S. L. Nutt, D. Vremec, S. Pietersz, M. H. Lahoud, L. Schofield, D. S. Hansen, et al. Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells J. Exp. Med., October 29, 2007; 204(11): 2579 - 2590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Coelho, M. A. Schaller, C. F. Benjamim, A. Z. Orlofsky, C. M. Hogaboam, and S. L. Kunkel The Chemokine CCL6 Promotes Innate Immunity via Immune Cell Activation and Recruitment J. Immunol., October 15, 2007; 179(8): 5474 - 5482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. I. Chaudhry, G. Plitas, B. M. Burt, T. P. Kingham, J. R. Raab, and R. P. DeMatteo NK Dendritic Cells Expanded in IL-15 Exhibit Antitumor Responses In Vivo J. Immunol., October 1, 2007; 179(7): 4654 - 4660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, E. Calomeni, J. Wen, K. Ozato, R. Shen, and J.-X. Gao Natural killer dendritic cells are an intermediate of developing dendritic cells J. Leukoc. Biol., June 1, 2007; 81(6): 1422 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Copin, P. De Baetselier, Y. Carlier, J.-J. Letesson, and E. Muraille MyD88-Dependent Activation of B220-CD11b+LY-6C+ Dendritic Cells during Brucella melitensis Infection J. Immunol., April 15, 2007; 178(8): 5182 - 5191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Plitas, U. I. Chaudhry, T. P. Kingham, J. R. Raab, and R. P. DeMatteo NK Dendritic Cells Are Innate Immune Responders to Listeria monocytogenes Infection J. Immunol., April 1, 2007; 178(7): 4411 - 4416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-R. Chang, K.-J. Wang, Y.-F. Lu, L.-J. Yang, W.-J. Chen, Y.-H. Lin, H.-H. Chang, and S.-L. Wang Characterization of Early Gamma Interferon (IFN-{gamma}) Expression during Murine Listeriosis: Identification of NK1.1+ CD11c+ Cells as the Primary IFN-{gamma}-Expressing Cells Infect. Immun., March 1, 2007; 75(3): 1167 - 1176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fujii, J. D. Trudeau, D. T. Teachey, J. D. Fish, S. A. Grupp, K. R. Schultz, and G. S. D. Reid In vivo control of acute lymphoblastic leukemia by immunostimulatory CpG oligonucleotides Blood, March 1, 2007; 109(5): 2008 - 2013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ullrich, M. Bonmort, G. Mignot, N. Chaput, J. Taieb, C. Menard, S. Viaud, T. Tursz, G. Kroemer, and L. Zitvogel Therapy-Induced Tumor Immunosurveillance Involves IFN-Producing Killer Dendritic Cells Cancer Res., February 1, 2007; 67(3): 851 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Vremec, M. O'Keeffe, H. Hochrein, M. Fuchsberger, I. Caminschi, M. Lahoud, and K. Shortman Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells Blood, February 1, 2007; 109(3): 1165 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yadav, D. J. Zammit, L. Lefrancois, and A. T. Vella Effects of LPS-mediated bystander activation in the innate immune system J. Leukoc. Biol., December 1, 2006; 80(6): 1251 - 1261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. I. Chaudhry, T. P. Kingham, G. Plitas, S. C. Katz, J. R. Raab, and R. P. DeMatteo Combined Stimulation with Interleukin-18 and CpG Induces Murine Natural Killer Dendritic Cells to Produce IFN-{gamma} and Inhibit Tumor Growth Cancer Res., November 1, 2006; 66(21): 10497 - 10504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Aranami, S. Miyake, and T. Yamamura Differential Expression of CD11c by Peripheral Blood NK Cells Reflects Temporal Activity of Multiple Sclerosis J. Immunol., October 15, 2006; 177(8): 5659 - 5667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-i. Fujii, K. Shimizu, H. Hemmi, M. Fukui, A. J. Bonito, G. Chen, R. W. Franck, M. Tsuji, and R. M. Steinman Glycolipid {alpha}-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice PNAS, July 25, 2006; 103(30): 11252 - 11257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Holl, M. Peressin, S. Schmidt, T. Decoville, S. Zolla-Pazner, A.-M. Aubertin, and C. Moog Efficient inhibition of HIV-1 replication in human immature monocyte-derived dendritic cells by purified anti-HIV-1 IgG without induction of maturation Blood, June 1, 2006; 107(11): 4466 - 4474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. I. Chaudhry, S. C. Katz, T. P. Kingham, V. G. Pillarisetty, J. R. Raab, A. B. Shah, and R. P. DeMatteo In vivo overexpression of Flt3 ligand expands and activates murine spleen natural killer dendritic cells FASEB J, May 1, 2006; 20(7): 982 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Shaw and M. N. Starnbach Stimulation of CD8+ T Cells following Diphtheria Toxin-Mediated Antigen Delivery into Dendritic Cells Infect. Immun., February 1, 2006; 74(2): 1001 - 1008. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
