|
|
||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Induces Early Lethal Lupus in Preautoimmune (New Zealand Black x New Zealand White)F1 but Not in BALB/c Mice1

* Baylor Institute for Immunology Research, Dallas, TX 75204; and
Department of Pathology, Childrens Hospital, Dallas, TX 75235
Recent studies indicate that IFN-
is involved in pathogenesis of systemic lupus erythematosus. However, direct proof that IFN-
is not only necessary, but also sufficient to induce lupus pathogenicity is lacking. In this study, we show that in vivo adenovector-mediated delivery of murine IFN-
results in preautoimmune (New Zealand Black (NZB) x New Zealand White (NZW))F1, but not in normal, mice, in a rapid and severe disease with all characteristics of systemic lupus erythematosus. Anti-dsDNA Abs appeared as soon as day 10 after initiation of IFN-
treatment. Proteinuria and death caused by glomerulonephritis occurred in all treated mice within, respectively,
9 and
18 wk, at a time when all untreated (NZB x NZW)F1 did not show any sign of disease. IFN-
in vivo induced an overexpression of B lymphocyte stimulator in circulation at similar levels in both the preautoimmune and the normal mouse strains. All effects elicited by IFN-
were dose dependent. (NZB x NZW)F1 infused with purified murine IFN-
also showed acceleration of lupus. Thus, prolonged expression of IFN-
in vivo induces early lethal lupus in susceptible animals.
Related articles in The JI:
This article has been cited by other articles:
![]() |
L. Adalid-Peralta, V. Godot, C. Colin, R. Krzysiek, T. Tran, P. Poignard, A. Venet, A. Hosmalin, P. Lebon, C. Rouzioux, et al. Stimulation of the primary anti-HIV antibody response by IFN-{alpha} in patients with acute HIV-1 infection J. Leukoc. Biol., April 1, 2008; 83(4): 1060 - 1067. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Mason and J. Berden Pathogenic factors for the development of lupus nephritis Lupus, March 1, 2008; 17(3): 251 - 255. [PDF] |
||||
![]() |
A. Rahman and D. A. Isenberg Systemic Lupus Erythematosus N. Engl. J. Med., February 28, 2008; 358(9): 929 - 939. [Full Text] [PDF] |
||||
![]() |
M. Yamauchi, M. Hashimoto, K. Ichiyama, R. Yoshida, T. Hanada, T. Muta, S. Komune, T. Kobayashi, and A. Yoshimura Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-{kappa}B activation in dendritic cells Int. Immunol., August 16, 2007; (2007) dxm054v1. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Wan, C. Xia, and L. Morel IL-6 Produced by Dendritic Cells from Lupus-Prone Mice Inhibits CD4+CD25+ T Cell Regulatory Functions J. Immunol., January 1, 2007; 178(1): 271 - 279. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Savarese, O.-w. Chae, S. Trowitzsch, G. Weber, B. Kastner, S. Akira, H. Wagner, R. M. Schmid, S. Bauer, and A. Krug U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7 Blood, April 15, 2006; 107(8): 3229 - 3234. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. C. Nacionales, K. M. Kelly, P. Y. Lee, H. Zhuang, Y. Li, J. S. Weinstein, E. Sobel, Y. Kuroda, J. Akaogi, M. Satoh, et al. Type I Interferon Production by Tertiary Lymphoid Tissue Developing in Response to 2,6,10,14-Tetramethyl-Pentadecane (Pristane) Am. J. Pathol., April 1, 2006; 168(4): 1227 - 1240. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Rutella, F. Zavala, S. Danese, H. Kared, and G. Leone Granulocyte Colony-Stimulating Factor: A Novel Mediator of T Cell Tolerance J. Immunol., December 1, 2005; 175(11): 7085 - 7091. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Schwarting, K. Paul, S. Tschirner, J. Menke, T. Hansen, W. Brenner, V. R. Kelley, M. Relle, and P. R. Galle Interferon-{beta}: A Therapeutic for Autoimmune Lupus in MRL-Faslpr Mice J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3264 - 3272. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Rahman, S. J. Bowman, I. P. Giles, Y. Ioannou, and D. A. Isenberg Annus mirabilis--a guide to the 6th European Lupus Meeting, 3-5 March 2005 Rheumatology, August 1, 2005; 44(8): 962 - 964. [Full Text] [PDF] |
||||
![]() |
Y Ioannou, S J Bowman, A Rahman, and I P Giles Review of presentations at the 6th European Lupus Meeting 3-5 March 2005 Lupus, June 1, 2005; 14(6): 467 - 478. [Abstract] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |