HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hashizume, H. Articles by Takigawa, M. Search for Related Content PubMed PubMed Citation Articles by Hashizume, H. Articles by Takigawa, M. Pubmed/NCBI databases Substance via MeSH

Compartmental Imbalance and Aberrant Immune Function of Blood CD123⁺ (Plasmacytoid) and CD11c⁺ (Myeloid) Dendritic Cells in Atopic Dermatitis¹

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan

Atopic dermatitis (AD) is a pruritic, chronically relapsing skin disease in which Th2 cells play a crucial role in cutaneous and extracutaneous immune reactions. In humans, CD11c⁺CD123^– myeloid dendritic cells (mDC) and CD11c^–CD123⁺ plasmacytoid DC (pDC) orchestrate the decision-making process in innate and acquired immunity. Since the number and function of these blood dendritic cell (DC) subsets reportedly reflect the host immune status, we studied the involvement of the DC subsets in the pathogenesis of AD. Patients with AD had an increased DC number and a low mDC:pDC ratio with pDC outnumbering mDC in the peripheral blood compared with normal subjects and psoriasis patients (a Th1 disease model group). The mDC:pDC ratio was correlated with the total serum IgE level, the ratio of IFN--producing blood cells:IL-4-producing blood cells, and the disease severity. In vitro allogeneic stimulation of naive CD4⁺ cells with atopic DC showed that the ability of pDC for Th1 induction was superior or comparable to that of mDC. In skin lesions, pDC infiltration was in close association with blood vessels expressing peripheral neural addressins. Therefore, compartmental imbalance and aberrant immune function of the blood DC subsets may deviate the Th1/Th2 differentiation and thus induce protracted allergic responses in AD.

This article has been cited by other articles:

				K. Bratke, M. Lommatzsch, P. Julius, M. Kuepper, H.-D. Kleine, W. Luttmann, and J Christian Virchow Dendritic cell subsets in human bronchoalveolar lavage fluid after segmental allergen challenge Thorax, February 1, 2007; 62(2): 168 - 175. [Abstract] [Full Text] [PDF]

				J. T. Schroeder, A. P. Bieneman, H. Xiao, K. L. Chichester, K. Vasagar, S. Saini, and M. C. Liu TLR9- and Fc{epsilon}RI-Mediated Responses Oppose One Another in Plasmacytoid Dendritic Cells by Down-Regulating Receptor Expression J. Immunol., November 1, 2005; 175(9): 5724 - 5731. [Abstract] [Full Text] [PDF]