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Dendritic Cells Induce MUC1 Expression and Polarization on Human T Cells by an IL-7-Dependent Mechanism¹

Baldev Vasir^*, David Avigan, Zekui Wu^*, Keith Crawford, Shawn Turnquist, Jian Ren^* and Donald Kufe^2,*

^* Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, and Center for Blood Research, Harvard Medical School, Boston, MA 02115

The MUC1 transmembrane mucin is expressed on the surface of activated human T cells; however, the physiologic signals responsible for the regulation of MUC1 in T cells are not known. The present studies demonstrate that IL-7, but not IL-2 or IL-4, markedly induces MUC1 expression on CD3⁺ T cells. MUC1 was also up-regulated by IL-15, but to a lesser extent than that found with IL-7. The results show that IL-7 up-regulates MUC1 on CD4⁺, CD8⁺, CD25⁺, CD69⁺, naive CD45RA⁺, and memory CD45RO⁺ T cells. In concert with induction of MUC1 expression by IL-7, activated dendritic cells (DC) that produce IL-7 up-regulate MUC1 on allogeneic CD3⁺ T cells. DC also induce MUC1 expression on autologous CD3⁺ T cells in the presence of recall Ag. Moreover, DC-induced MUC1 expression on T cells is blocked by a neutralizing anti-IL-7 Ab. The results also demonstrate that DC induce polarization of MUC1 on T cells at sites opposing the DC-T cell synapse. These findings indicate that DC-mediated activation of Ag-specific T cells is associated with induction and polarization of MUC1 expression by an IL-7-dependent mechanism.

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