The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cailhier, J. F.
Right arrow Articles by Lang, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cailhier, J. F.
Right arrow Articles by Lang, R. A.
The Journal of Immunology, 2005, 174: 2336-2342.
Copyright © 2005 by The American Association of Immunologists

Conditional Macrophage Ablation Demonstrates That Resident Macrophages Initiate Acute Peritoneal Inflammation1

Jean Francois Cailhier2,*, Marina Partolina2,3,{dagger}, Srilatha Vuthoori2,4,{dagger}, Shengji Wu2,{dagger}, Kyung Ko5,{dagger}, Simon Watson*, John Savill*, Jeremy Hughes2,6,* and Richard A. Lang2,{dagger}

* Phagocyte Laboratory, Medical Research Council Center for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom; and {dagger} Dr. Richard A. Lang Division of Developmental Biology and Department of Ophthalmology, Children’s Hospital Research Foundation, Cincinnati, OH 45229

The role played by resident macrophages (M{phi}) in the initiation of peritoneal inflammation is currently unclear. We have used a conditional M{phi} ablation strategy to determine the role of resident peritoneal M{phi} in the regulation of neutrophil (PMN) recruitment in experimental peritonitis. We developed a novel conditional M{phi} ablation transgenic mouse (designated CD11bDTR) based upon CD11b promoter-mediated expression of the human diphtheria toxin (DT) receptor. The murine DT receptor binds DT poorly such that expression of the human receptor confers toxin sensitivity. Intraperitoneal injection of minute (nanogram) doses of DT results in rapid and marked ablation of F4/80-positive M{phi} populations in the peritoneum as well as the kidney, and ovary. In experimental peritonitis, resident M{phi} ablation resulted in a dramatic attenuation of PMN infiltration that was rescued by the adoptive transfer of resident nontransgenic M{phi}. Attenuation of PMN infiltration was associated with diminished CXC chemokine production at 1 h. These studies indicate a key role for resident peritoneal M{phi} in sensing perturbation to the peritoneal microenvironment and regulating PMN infiltration.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
S. L. Lin, A. P. Castano, B. T. Nowlin, M. L. Lupher Jr., and J. S. Duffield
Bone Marrow Ly6Chigh Monocytes Are Selectively Recruited to Injured Kidney and Differentiate into Functionally Distinct Populations
J. Immunol., November 15, 2009; 183(10): 6733 - 6743.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Z. He, B. Dursun, D.-J. Oh, L. Lu, S. Faubel, and C. L. Edelstein
Macrophages are not the source of injurious interleukin-18 in ischemic acute kidney injury in mice
Am J Physiol Renal Physiol, March 1, 2009; 296(3): F535 - F542.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. N. Gorgani, J. Q. He, K. J. Katschke Jr., K. Y. Helmy, H. Xi, M. Steffek, P. E. Hass, and M. van Lookeren Campagne
Complement Receptor of the Ig Superfamily Enhances Complement-Mediated Phagocytosis in a Subpopulation of Tissue Resident Macrophages
J. Immunol., December 1, 2008; 181(11): 7902 - 7908.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Dioszeghy, M. Rosas, B. H. Maskrey, C. Colmont, N. Topley, P. Chaitidis, H. Kuhn, S. A. Jones, P. R. Taylor, and V. B. O'Donnell
12/15-Lipoxygenase Regulates the Inflammatory Response to Bacterial Products In Vivo
J. Immunol., November 1, 2008; 181(9): 6514 - 6524.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Gelati, A. C. Aplin, E. Fogel, K. D. Smith, and R. F. Nicosia
The Angiogenic Response of the Aorta to Injury and Inflammatory Cytokines Requires Macrophages
J. Immunol., October 15, 2008; 181(8): 5711 - 5719.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
H. Kitamura, M. Ito, T. Yuasa, C. Kikuguchi, A. Hijikata, M. Takayama, Y. Kimura, R. Yokoyama, T. Kaji, and O. Ohara
Genome-wide identification and characterization of transcripts translationally regulated by bacterial lipopolysaccharide in macrophage-like J774.1 cells
Physiol Genomics, October 8, 2008; 33(1): 121 - 132.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C. H. Y. Fong, M. Bebien, A. Didierlaurent, R. Nebauer, T. Hussell, D. Broide, M. Karin, and T. Lawrence
An antiinflammatory role for IKK{beta} through the inhibition of "classical" macrophage activation
J. Exp. Med., June 9, 2008; 205(6): 1269 - 1276.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. De Filippo, R. B. Henderson, M. Laschinger, and N. Hogg
Neutrophil Chemokines KC and Macrophage-Inflammatory Protein-2 Are Newly Synthesized by Tissue Macrophages Using Distinct TLR Signaling Pathways
J. Immunol., March 15, 2008; 180(6): 4308 - 4315.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
N. C. Henderson, A. C. Mackinnon, S. L. Farnworth, T. Kipari, C. Haslett, J. P. Iredale, F.-T. Liu, J. Hughes, and T. Sethi
Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis
Am. J. Pathol., February 1, 2008; 172(2): 288 - 298.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Rajakariar, M. Hilliard, T. Lawrence, S. Trivedi, P. Colville-Nash, G. Bellingan, D. Fitzgerald, M. M. Yaqoob, and D. W. Gilroy
From the Cover: Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxy{Delta}12-14 PGJ2
PNAS, December 26, 2007; 104(52): 20979 - 20984.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. M. DiPasquale, M. Cheng, W. Billich, S. A. Huang, N. van Rooijen, T. A. Hornberger, and T. J. Koh
Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in mice
Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1278 - C1285.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C. Varol, L. Landsman, D. K. Fogg, L. Greenshtein, B. Gildor, R. Margalit, V. Kalchenko, F. Geissmann, and S. Jung
Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
J. Exp. Med., January 22, 2007; 204(1): 171 - 180.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. S. Duffield, S. Hong, V. S. Vaidya, Y. Lu, G. Fredman, C. N. Serhan, and J. V. Bonventre
Resolvin D Series and Protectin D1 Mitigate Acute Kidney Injury
J. Immunol., November 1, 2006; 177(9): 5902 - 5911.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Kipari, J.-F. Cailhier, D. Ferenbach, S. Watson, K. Houlberg, D. Walbaum, S. Clay, J. Savill, and J. Hughes
Nitric Oxide Is an Important Mediator of Renal Tubular Epithelial Cell Death in Vitro and in Murine Experimental Hydronephrosis
Am. J. Pathol., August 1, 2006; 169(2): 388 - 399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. F. Cailhier, D. A. Sawatzky, T. Kipari, K. Houlberg, D. Walbaum, S. Watson, R. A. Lang, S. Clay, D. Kluth, J. Savill, et al.
Resident Pleural Macrophages Are Key Orchestrators of Neutrophil Recruitment in Pleural Inflammation
Am. J. Respir. Crit. Care Med., March 1, 2006; 173(5): 540 - 547.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. A. Shaw and M. N. Starnbach
Stimulation of CD8+ T Cells following Diphtheria Toxin-Mediated Antigen Delivery into Dendritic Cells
Infect. Immun., February 1, 2006; 74(2): 1001 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. S. Duffield, P. G. Tipping, T. Kipari, J.-F. Cailhier, S. Clay, R. Lang, J. V. Bonventre, and J. Hughes
Conditional Ablation of Macrophages Halts Progression of Crescentic Glomerulonephritis
Am. J. Pathol., November 1, 2005; 167(5): 1207 - 1219.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. J. Cummings, N. Uchida, S. J. Tamaki, D. L. Salazar, M. Hooshmand, R. Summers, F. H. Gage, and A. J. Anderson
Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice
PNAS, September 27, 2005; 102(39): 14069 - 14074.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Matsukawa, S. Kudo, T. Maeda, K. Numata, H. Watanabe, K. Takeda, S. Akira, and T. Ito
Stat3 in Resident Macrophages as a Repressor Protein of Inflammatory Response
J. Immunol., September 1, 2005; 175(5): 3354 - 3359.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.