| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814;
University of Cincinnati College of Medicine and the Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45267; and
Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, U.S. Department of Agriculture, Beltsville, MD 20705
The intestinal nematode parasite, Nippostrongylus brasiliensis, triggers potent type 2 immunity. Using OVA peptide as a model Ag, we have examined the adjuvant effects of this parasite on the in vivo development of Ag-specific Th2 cells from naive DO11.10 T cells. Our findings show that Th2 cells can develop from transferred naive OVA-specific DO11.10 T cells in recipient IL-4–/– mice inoculated with N. brasiliensis plus OVA. However, autocrine IL-4 is required for in situ Th2 cell differentiation since transferred IL-4R
-deficient DO11.10 T cells showed greatly reduced Th2 cell development in inoculated IL-4–/– recipient mice. Surprisingly, we also found that IL-2 blockade promoted B7-dependent T cell cycling, but inhibited the development of OVA-specific Th2 cells. Furthermore, the effects of IL-2 occurred independently of CD25+ T regulatory cells. These studies establish a previously unrecognized requirement for autocrine IL-4 and IL-2 in Th2 responses elicited by nematode parasites.
This article has been cited by other articles:
|
|
 |
|
  A. M. Dittrich, H.-C. Chen, L. Xu, P. Ranney, S. Connolly, T. O. Yarovinsky, and H. K. Bottomly A New Mechanism for Inhalational Priming: IL-4 Bypasses Innate Immune Signals J. Immunol., November 15, 2008; 181(10): 7307 - 7315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mostbock, M. E. C. Lutsiak, D. E. Milenic, K. Baidoo, J. Schlom, and H. Sabzevari IL-2/Anti-IL-2 Antibody Complex Enhances Vaccine-Mediated Antigen-Specific CD8+ T Cell Responses and Increases the Ratio of Effector/Memory CD8+ T Cells to Regulatory T Cells J. Immunol., April 1, 2008; 180(7): 5118 - 5129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. S. King, A. M. Knorn, C. Ohnmacht, and D. Voehringer Accumulation of Effector CD4 T Cells during Type 2 Immune Responses Is Negatively Regulated by Stat6 J. Immunol., January 15, 2008; 180(2): 754 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Pesce, Z. Liu, H. Hamed, F. Alem, J. Whitmire, H. Lin, Q. Liu, J. F. Urban Jr., and W. C. Gause Neutrophils Clear Bacteria Associated with Parasitic Nematodes Augmenting the Development of an Effective Th2-Type Response J. Immunol., January 1, 2008; 180(1): 464 - 474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Liu, Z. Liu, C. T. Rozo, H. A. Hamed, F. Alem, J. F. Urban Jr., and W. C. Gause The Role of B Cells in the Development of CD4 Effector T Cells during a Polarized Th2 Immune Response J. Immunol., September 15, 2007; 179(6): 3821 - 3830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Dolan, K. D. Gibbs Jr, and S. Ostrand-Rosenberg Dendritic Cells Cross-Dressed with Peptide MHC Class I Complexes Prime CD8+ T Cells J. Immunol., November 1, 2006; 177(9): 6018 - 6024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Voehringer, T. A. Reese, X. Huang, K. Shinkai, and R. M. Locksley Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system J. Exp. Med., June 12, 2006; 203(6): 1435 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. So, J. Song, K. Sugie, A. Altman, and M. Croft Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment PNAS, March 7, 2006; 103(10): 3740 - 3745. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
