HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Xiao, Y. Articles by Zhong, G. Search for Related Content PubMed PubMed Citation Articles by Xiao, Y. Articles by Zhong, G. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CYCLOHEXIMIDE

NF-B Activation Is Not Required for Chlamydia trachomatis Inhibition of Host Epithelial Cell Apoptosis¹

Yangming Xiao^*, Youmin Zhong^*, Heng Su^*,, Zhiguang Zhou, Paul Chiao and Guangming Zhong^2,*

^* Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; Institute of Metabolism and Endocrinology, Central South University Xiangya Medical College, Hunan, China; and Department of Molecular and Cellular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030

Chlamydia trachomatis, an obligate intracellular bacterial species, is known to inhibit host cell apoptosis. However, the chlamydial antiapoptotic mechanism is still not clear. Because NF-B activation is antiapoptotic, we tested the potential role of NF-B activation in chlamydial antiapoptotic activity in the current study. First, no obvious NF-B activation was detected in the chlamydia-infected cells when these cells were resistant to apoptosis induced via either the intrinsic or extrinsic apoptosis pathways. Second, inhibition of NF-B activation with pharmacologic reagents failed to block the chlamydial antiapoptotic activity. Finally, NF-B p65 gene deletion did not prevent chlamydia from inhibiting host cell apoptosis. These observations together have demonstrated that NF-B activation is not required for the chlamydial antiapoptotic activity.

This article has been cited by other articles:

				X. Zhang, L. Gao, L. Lei, Y. Zhong, P. Dube, M. T. Berton, B. Arulanandam, J. Zhang, and G. Zhong A MyD88-Dependent Early IL-17 Production Protects Mice against Airway Infection with the Obligate Intracellular Pathogen Chlamydia muridarum J. Immunol., July 15, 2009; 183(2): 1291 - 1300. [Abstract] [Full Text] [PDF]

				Z. Li, D. Chen, Y. Zhong, S. Wang, and G. Zhong The Chlamydial Plasmid-Encoded Protein pgp3 Is Secreted into the Cytosol of Chlamydia-Infected Cells Infect. Immun., August 1, 2008; 76(8): 3415 - 3428. [Abstract] [Full Text] [PDF]

				Z. Li, C. Chen, D. Chen, Y. Wu, Y. Zhong, and G. Zhong Characterization of Fifty Putative Inclusion Membrane Proteins Encoded in the Chlamydia trachomatis Genome Infect. Immun., June 1, 2008; 76(6): 2746 - 2757. [Abstract] [Full Text] [PDF]

				W. Cheng, P. Shivshankar, Y. Zhong, D. Chen, Z. Li, and G. Zhong Intracellular Interleukin-1{alpha} Mediates Interleukin-8 Production Induced by Chlamydia trachomatis Infection via a Mechanism Independent of Type I Interleukin-1 Receptor Infect. Immun., March 1, 2008; 76(3): 942 - 951. [Abstract] [Full Text] [PDF]

				R. K. Herman, R. E. Molestina, A. P. Sinai, and D. K. Howe The Apicomplexan Pathogen Neospora caninum Inhibits Host Cell Apoptosis in the Absence of Discernible NF-{kappa}B Activation Infect. Immun., September 1, 2007; 75(9): 4255 - 4262. [Abstract] [Full Text] [PDF]

				R. Flores, J. Luo, D. Chen, G. Sturgeon, P. Shivshankar, Y. Zhong, and G. Zhong Characterization of the hypothetical protein Cpn1027, a newly identified inclusion membrane protein unique to Chlamydia pneumoniae Microbiology, March 1, 2007; 153(3): 777 - 786. [Abstract] [Full Text] [PDF]

				M. Pirbhai, F. Dong, Y. Zhong, K. Z. Pan, and G. Zhong The Secreted Protease Factor CPAF Is Responsible for Degrading Pro-apoptotic BH3-only Proteins in Chlamydia trachomatis-infected Cells J. Biol. Chem., October 20, 2006; 281(42): 31495 - 31501. [Abstract] [Full Text] [PDF]

				C. Chen, D. Chen, J. Sharma, W. Cheng, Y. Zhong, K. Liu, J. Jensen, R. Shain, B. Arulanandam, and G. Zhong The Hypothetical Protein CT813 Is Localized in the Chlamydia trachomatis Inclusion Membrane and Is Immunogenic in Women Urogenitally Infected with C. trachomatis. Infect. Immun., August 1, 2006; 74(8): 4826 - 4840. [Abstract] [Full Text] [PDF]

				J. Sharma, F. Dong, M. Pirbhai, and G. Zhong Inhibition of Proteolytic Activity of a Chlamydial Proteasome/Protease-Like Activity Factor by Antibodies from Humans Infected with Chlamydia trachomatis Infect. Immun., July 1, 2005; 73(7): 4414 - 4419. [Abstract] [Full Text] [PDF]