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The Journal of Immunology, 2005, 174: 1501-1506.
Copyright © 2005 by The American Association of Immunologists

Ig-Independent Ig{beta} Expression on the Surface of B Lymphocytes after B Cell Receptor Aggregation1

Marina Kremyanskaya and John G. Monroe2

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104

In order for humoral immune responses to develop, B cells must be able to recognize, bind, and internalize Ags. These functions are performed by the BCR, which is also responsible for initiating and transducing activation signals necessary for B cell proliferation and differentiation. We have examined surface expression patterns of individual components of the BCR following anti-Ig- and Ag-induced aggregation. Specifically, the localization and expression levels of the Ag-binding component, surface Ig (sIg), and the Ig{beta} component of the Ig{alpha}/Ig{beta} signaling unit were investigated to determine their individual participation in the internalization and signal transduction. Using primary murine B cells, we found that while >95% of the sIg is internalized following anti-Ig-induced aggregation, 20–30% of Ig{beta} remains on the surface. These results suggest that sIg and Ig{beta} may function independently following the initial stages of signal transduction.


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