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Ig-Independent Ig Expression on the Surface of B Lymphocytes after B Cell Receptor Aggregation¹

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104

In order for humoral immune responses to develop, B cells must be able to recognize, bind, and internalize Ags. These functions are performed by the BCR, which is also responsible for initiating and transducing activation signals necessary for B cell proliferation and differentiation. We have examined surface expression patterns of individual components of the BCR following anti-Ig- and Ag-induced aggregation. Specifically, the localization and expression levels of the Ag-binding component, surface Ig (sIg), and the Ig component of the Ig/Ig signaling unit were investigated to determine their individual participation in the internalization and signal transduction. Using primary murine B cells, we found that while >95% of the sIg is internalized following anti-Ig-induced aggregation, 20–30% of Ig remains on the surface. These results suggest that sIg and Ig may function independently following the initial stages of signal transduction.

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The JI 2005 174: 1139-1141. [Full Text]  

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