HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dai, Z. Articles by Lakkis, F. G. Search for Related Content PubMed PubMed Citation Articles by Dai, Z. Articles by Lakkis, F. G.

Impaired Recall of CD8 Memory T Cells in Immunologically Privileged Tissue¹

Zhenhua Dai^*,, Isam W. Nasr^*,, Michael Reel, Songyan Deng^*, Lonnette Diggs^*,, Christian P. Larsen, David M. Rothstein^* and Fadi G. Lakkis^2,*,

^* Section of Nephrology, Department of Internal Medicine, and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520; and Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322

Foreign Ags that enter immunologically privileged sites such as the eye, brain, and testis persist for an extended period of time, whereas the same Ags are rapidly eliminated at conventional sites. Immune privilege, therefore, provides unwanted refuge for pathogens and tumor cells but is beneficial for the survival of allogeneic grafts. In this study, we asked whether memory T cells can eliminate foreign Ags deposited at an immunologically privileged site by studying CD8 memory T cell-mediated rejection of pancreatic islet allografts placed either in the testis (a privileged organ) or under the kidney capsule (a nonprivileged site) of diabetic mice. We found that CD8 memory T cells reject intratesticular grafts at a significantly slower rate than the rejection of intrarenal grafts. Delayed graft rejection in the testis was not due to reduced homing or proliferation of memory T cells but due to their increased apoptosis at that site. Apoptosis was mediated by the combined actions of two TNFR family members that are up-regulated on activated memory T cells, Fas, and CD30. Therefore, memory T cells survey immunologically privileged tissues but are subject to the immunosuppressive mechanisms present at these sites.

This article has been cited by other articles:

				V. Dal Secco, A. Riccioli, F. Padula, E. Ziparo, and A. Filippini Mouse Sertoli Cells Display Phenotypical and Functional Traits of Antigen-Presenting Cells in Response to Interferon Gamma Biol Reprod, February 1, 2008; 78(2): 234 - 242. [Abstract] [Full Text] [PDF]

				J. Yang, M. O. Brook, M. Carvalho-Gaspar, J. Zhang, H. E. Ramon, M. H. Sayegh, K. J. Wood, L. A. Turka, and N. D. Jones Allograft rejection mediated by memory T cells is resistant to regulation PNAS, December 11, 2007; 104(50): 19954 - 19959. [Abstract] [Full Text] [PDF]

				J. Stein-Streilein and A. W. Taylor An eye's view of T regulatory cells J. Leukoc. Biol., March 1, 2007; 81(3): 593 - 598. [Abstract] [Full Text] [PDF]

				S. V. Krysov, T. F. Rowley, and A. Al-Shamkhani Inhibition of p38 mitogen-activated protein kinase unmasks a CD30-triggered apoptotic pathway in anaplastic large cell lymphoma cells Mol. Cancer Ther., February 1, 2007; 6(2): 703 - 711. [Abstract] [Full Text] [PDF]

				C. Ramakrishna, R. A. Atkinson, S. A. Stohlman, and C. C. Bergmann Vaccine-Induced Memory CD8+ T Cells Cannot Prevent Central Nervous System Virus Reactivation. J. Immunol., March 1, 2006; 176(5): 3062 - 3069. [Abstract] [Full Text] [PDF]

				I. W. Nasr, Y. Wang, G. Gao, S. Deng, L. Diggs, D. M. Rothstein, G. Tellides, F. G. Lakkis, and Z. Dai Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells J. Immunol., May 15, 2005; 174(10): 6161 - 6168. [Abstract] [Full Text] [PDF]