The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kamath, A. T.
Right arrow Articles by Tough, D. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kamath, A. T.
Right arrow Articles by Tough, D. F.
The Journal of Immunology, 2005, 174: 767-776.
Copyright © 2005 by The American Association of Immunologists

Dendritic Cells and NK Cells Stimulate Bystander T Cell Activation in Response to TLR Agonists through Secretion of IFN-{alpha}{beta} and IFN-{gamma}1

Arun T. Kamath, Christopher E. Sheasby and David F. Tough2

The Edward Jenner Institute for Vaccine Research, Compton, Newbury, United Kingdom

Recognition of conserved features of infectious agents by innate pathogen receptors plays an important role in initiating the adaptive immune response. We have investigated early changes occurring among T cells after injection of TLR agonists into mice. Widespread, transient phenotypic activation of both naive and memory T cells was observed rapidly after injection of molecules acting through TLR3, -4, -7, and -9, but not TLR2. T cell activation was shown to be mediated by a combination of IFN-{alpha}{beta}, secreted by dendritic cells (DCs), and IFN-{gamma}, secreted by NK cells; notably, IFN-{gamma}-secreting NK cells expressed CD11c and copurified with DCs. Production of IFN-{gamma} by NK cells could be stimulated by DCs from TLR agonist-injected mice, and although soluble factors secreted by LPS-stimulated DCs were sufficient to induce IFN-{gamma}, maximal IFN-{gamma} production required both direct contact of NK cells with DCs and DC-secreted cytokines. In vitro, IFN-{alpha}{beta}, IL-18, and IL-12 all contributed to DC stimulation of NK cell IFN-{gamma}, whereas IFN-{alpha}{beta} was shown to be important for induction of T cell bystander activation and NK cell IFN-{gamma} production in vivo. The results delineate a pathway involving innate immune mediators through which TLR agonists trigger bystander activation of T cells.




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
Y. Zhang, T. Ohkuri, D. Wakita, Y. Narita, K. Chamoto, H. Kitamura, and T. Nishimura
Sialyl lewisx antigen-expressing human CD4+ T and CD8+ T cells as initial immune responders in memory phenotype subsets
J. Leukoc. Biol., September 1, 2008; 84(3): 730 - 735.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Martinez-Soria, M.-L. Santiago-Raber, L. Ho, T. Moll, and S. Izui
Protection of Murine Systemic Lupus by the Ea Transgene without Expression of I-E Heterodimers
J. Immunol., September 1, 2008; 181(5): 3651 - 3657.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Errington, L. Steele, R. Prestwich, K. J. Harrington, H. S. Pandha, L. Vidal, J. de Bono, P. Selby, M. Coffey, R. Vile, et al.
Reovirus Activates Human Dendritic Cells to Promote Innate Antitumor Immunity
J. Immunol., May 1, 2008; 180(9): 6018 - 6026.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. P. McAleer, D. J. Zammit, L. Lefrancois, R. J. Rossi, and A. T. Vella
The Lipopolysaccharide Adjuvant Effect on T Cells Relies on Nonoverlapping Contributions from the MyD88 Pathway and CD11c+ Cells
J. Immunol., November 15, 2007; 179(10): 6524 - 6535.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Lan, E. R. Kandimalla, D. Yu, L. Bhagat, Y. Li, D. Wang, F. Zhu, J. X. Tang, M. R. Putta, Y. Cong, et al.
Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8
PNAS, August 21, 2007; 104(34): 13750 - 13755.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. T. Robinson and J. D. Gorham
TGF-beta1 Regulates Antigen-Specific CD4+ T Cell Responses in the Periphery
J. Immunol., July 1, 2007; 179(1): 71 - 79.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Bourquin, L. Schmidt, V. Hornung, C. Wurzenberger, D. Anz, N. Sandholzer, S. Schreiber, A. Voelkl, G. Hartmann, and S. Endres
Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response
Blood, April 1, 2007; 109(7): 2953 - 2960.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Uchida, P. O. Scumpia, D. M. Murasko, S. Seki, S. Woulfe, M. J. Clare-Salzler, and L. L. Moldawer
Variable Requirement of Dendritic Cells for Recruitment of NK and T Cells to Different TLR Agonists
J. Immunol., March 15, 2007; 178(6): 3886 - 3892.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
T. P. Kenny, C. L. Keen, H. H. Schmitz, and M. E. Gershwin
Immune Effects of Cocoa Procyanidin Oligomers on Peripheral Blood Mononuclear Cells
Experimental Biology and Medicine, February 1, 2007; 232(2): 293 - 300.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
R. Yadav, D. J. Zammit, L. Lefrancois, and A. T. Vella
Effects of LPS-mediated bystander activation in the innate immune system
J. Leukoc. Biol., December 1, 2006; 80(6): 1251 - 1261.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
H. Hwa Cho, Y. C. Bae, and J. S. Jung
Role of Toll-Like Receptors on Human Adipose-Derived Stromal Cells
Stem Cells, December 1, 2006; 24(12): 2744 - 2752.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
U. I. Chaudhry, T. P. Kingham, G. Plitas, S. C. Katz, J. R. Raab, and R. P. DeMatteo
Combined Stimulation with Interleukin-18 and CpG Induces Murine Natural Killer Dendritic Cells to Produce IFN-{gamma} and Inhibit Tumor Growth
Cancer Res., November 1, 2006; 66(21): 10497 - 10504.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
K. S. Gorski, E. L. Waller, J. Bjornton-Severson, J. A. Hanten, C. L. Riter, W. C. Kieper, K. B. Gorden, J. S. Miller, J. P. Vasilakos, M. A. Tomai, et al.
Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists
Int. Immunol., July 1, 2006; 18(7): 1115 - 1126.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-f. Kwa, P. Beverley, and A. L. Smith
Peyer's Patches Are Required for the Induction of Rapid Th1 Responses in the Gut and Mesenteric Lymph Nodes during an Enteric Infection.
J. Immunol., June 15, 2006; 176(12): 7533 - 7541.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Eriksson, S. K. Meadows, S. Basu, T. F. Mselle, C. R. Wira, and C. L. Sentman
TLRs Mediate IFN-{gamma} Production by Human Uterine NK Cells in Endometrium
J. Immunol., May 15, 2006; 176(10): 6219 - 6224.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
U. I. Chaudhry, S. C. Katz, T. P. Kingham, V. G. Pillarisetty, J. R. Raab, A. B. Shah, and R. P. DeMatteo
In vivo overexpression of Flt3 ligand expands and activates murine spleen natural killer dendritic cells
FASEB J, May 1, 2006; 20(7): 982 - 984.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. Martinez-Sobrido, N. Gitiban, A. Fernandez-Sesma, J. Cros, S. E. Mertz, N. A. Jewell, S. Hammond, E. Flano, R. K. Durbin, A. Garcia-Sastre, et al.
Protection against Respiratory Syncytial Virus by a Recombinant Newcastle Disease Virus Vector
J. Virol., February 1, 2006; 80(3): 1130 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Wesch, S. Beetz, H.-H. Oberg, M. Marget, K. Krengel, and D. Kabelitz
Direct Costimulatory Effect of TLR3 Ligand Poly(I:C) on Human {gamma}{delta} T Lymphocytes
J. Immunol., February 1, 2006; 176(3): 1348 - 1354.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. Polley, S. Stager, S. Prickett, A. Maroof, S. Zubairi, D. F. Smith, and P. M. Kaye
Adoptive Immunotherapy against Experimental Visceral Leishmaniasis with CD8+ T Cells Requires the Presence of Cognate Antigen
Infect. Immun., January 1, 2006; 74(1): 773 - 776.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Uehara, C. M. Chase, W. H. Kitchens, H. S. Rose, R. B. Colvin, P. S. Russell, and J. C. Madsen
NK Cells Can Trigger Allograft Vasculopathy: The Role of Hybrid Resistance in Solid Organ Allografts
J. Immunol., September 1, 2005; 175(5): 3424 - 3430.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. M. Arnaboldi, M. J. Behr, and D. W. Metzger
Mucosal B Cell Deficiency in IgA-/- Mice Abrogates the Development of Allergic Lung Inflammation
J. Immunol., July 15, 2005; 175(2): 1276 - 1285.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.