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The Journal of Immunology, 2005, 174: 614-618.
Copyright © 2005 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: MHC Class II-Restricted Killing In Vivo during Viral Infection1

Evan R. Jellison, Sung-Kwon Kim and Raymond M. Welsh2

Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655

Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.




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