|
|
||||||||
CUTTING EDGE |
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655
Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.
This article has been cited by other articles:
![]() |
S. A. Brown, J. L. Hurwitz, A. Zirkel, S. Surman, T. Takimoto, I. Alymova, C. Coleclough, A. Portner, P. C. Doherty, and K. S. Slobod A Recombinant Sendai Virus Is Controlled by CD4+ Effector T Cells Responding to a Secreted Human Immunodeficiency Virus Type 1 Envelope Glycoprotein J. Virol., November 15, 2007; 81(22): 12535 - 12542. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. J. Tyznik and M. J. Bevan The Surprising Kinetics of the T Cell Response to Live Antigenic Cells J. Immunol., October 15, 2007; 179(8): 4988 - 4995. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. S. Zimmermann, A. Casati, C. Schiering, S. Caserta, R. H. Michelini, V. Basso, and A. Mondino Tumors Hamper the Immunogenic Competence of CD4+ T Cell-Directed Dendritic Cell Vaccination J. Immunol., September 1, 2007; 179(5): 2899 - 2909. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Mitra-Kaushik, J. Cruz, L. J. Stern, F. A. Ennis, and M. Terajima Human Cytotoxic CD4+ T Cells Recognize HLA-DR1-Restricted Epitopes on Vaccinia Virus Proteins A24R and D1R Conserved among Poxviruses J. Immunol., July 15, 2007; 179(2): 1303 - 1312. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Moutaftsi, H.-H. Bui, B. Peters, J. Sidney, S. Salek-Ardakani, C. Oseroff, V. Pasquetto, S. Crotty, M. Croft, E. J. Lefkowitz, et al. Vaccinia Virus-Specific CD4+ T Cell Responses Target a Set of Antigens Largely Distinct from Those Targeted by CD8+ T Cell Responses J. Immunol., June 1, 2007; 178(11): 6814 - 6820. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. M. Sitati and M. S. Diamond CD4+ T-Cell Responses Are Required for Clearance of West Nile Virus from the Central Nervous System J. Virol., December 15, 2006; 80(24): 12060 - 12069. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Charalambous, M. Oks, G. Nchinda, S. Yamazaki, and R. M. Steinman Dendritic Cell Targeting of Survivin Protein in a Xenogeneic Form Elicits Strong CD4+ T Cell Immunity to Mouse Survivin J. Immunol., December 15, 2006; 177(12): 8410 - 8421. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. M. Brown, A. M. Dilzer, D. L. Meents, and S. L. Swain CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J. Immunol., September 1, 2006; 177(5): 2888 - 2898. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. N. Heller, C. Gurer, and C. Munz Virus-specific CD4+ T cells: ready for direct attack J. Exp. Med., April 17, 2006; 203(4): 805 - 808. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. K. Whitmire, N. Benning, and J. L. Whitton Precursor Frequency, Nonlinear Proliferation, and Functional Maturation of Virus-Specific CD4+ T Cells. J. Immunol., March 1, 2006; 176(5): 3028 - 3036. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. J. Cohen, Z. Zheng, R. Bray, Y. Zhao, L. A. Sherman, S. A. Rosenberg, and R. A. Morgan Recognition of Fresh Human Tumor by Human Peripheral Blood Lymphocytes Transduced with a Bicistronic Retroviral Vector Encoding a Murine Anti-p53 TCR J. Immunol., November 1, 2005; 175(9): 5799 - 5808. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Neumann, C. Wagner, K.-D. Preuss, B. Kubuschok, C. Schormann, S. Stevanovic, and M. Pfreundschuh Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells Blood, November 1, 2005; 106(9): 3105 - 3113. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. R. Hegde, C. Dunn, D. M. Lewinsohn, M. A. Jarvis, J. A. Nelson, and D. C. Johnson Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL J. Exp. Med., October 17, 2005; 202(8): 1109 - 1119. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. J. Zaunders, M. L. Munier, D. E. Kaufmann, S. Ip, P. Grey, D. Smith, T. Ramacciotti, D. Quan, R. Finlayson, J. Kaldor, et al. Early proliferation of CCR5+ CD38+++ antigen-specific CD4+ Th1 effector cells during primary HIV-1 infection Blood, September 1, 2005; 106(5): 1660 - 1667. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Guo, H. Niiya, T. Azuma, N. Uchida, Y. Yakushijin, I. Sakai, T. Hato, M. Takahashi, S. Senju, Y. Nishimura, et al. Direct recognition and lysis of leukemia cells by WT1-specific CD4+ T lymphocytes in an HLA class II-restricted manner Blood, August 15, 2005; 106(4): 1415 - 1418. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Santosuosso, X. Zhang, S. McCormick, J. Wang, M. Hitt, and Z. Xing Mechanisms of Mucosal and Parenteral Tuberculosis Vaccinations: Adenoviral-Based Mucosal Immunization Preferentially Elicits Sustained Accumulation of Immune Protective CD4 and CD8 T Cells within the Airway Lumen J. Immunol., June 15, 2005; 174(12): 7986 - 7994. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |