| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455
Clonal expansion of T cells requires cell division and survival during the proliferative phase of the response. Naive murine CD8 T cells responding to Ag and costimulation undergo an abortive response characterized by impaired clonal expansion, failure to develop effector functions, and long-term tolerance. A third signal provided by IL-12 is required for full expansion, activation, and establishment of memory. The enhanced survival, and thus clonal expansion, supported by IL-12 is not due to increased Bcl-2 or Bcl-xL expression; both are maximally activated by signals 1 and 2. In contrast, Bcl-3, recently shown to enhance survival when ectopically expressed in T cells, is increased only when IL-12 is present. Furthermore, examination of Bcl-3-deficient CD8 T cells demonstrates that the increased survival caused by IL-12 depends upon Bcl-3. The time courses of expression suggest that Bcl-2 and Bcl-xL promote survival early in the response, whereas Bcl-3 acts later in the response.
This article has been cited by other articles:
|
|
 |
|
  P. Agarwal, A. Raghavan, S. L. Nandiwada, J. M. Curtsinger, P. R. Bohjanen, D. L. Mueller, and M. F. Mescher Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory J. Immunol., August 1, 2009; 183(3): 1695 - 1704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. V. Shurin, I. L. Tourkova, R. Kaneno, and M. R. Shurin Chemotherapeutic Agents in Noncytotoxic Concentrations Increase Antigen Presentation by Dendritic Cells via an IL-12-Dependent Mechanism J. Immunol., July 1, 2009; 183(1): 137 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. J. Bassetti, J. White, J. W. Kappler, and P. Marrack Transgenic Bcl-3 slows T cell proliferation Int. Immunol., April 1, 2009; 21(4): 339 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Xiao, K. A. Casey, S. C. Jameson, J. M. Curtsinger, and M. F. Mescher Programming for CD8 T Cell Memory Development Requires IL-12 or Type I IFN J. Immunol., March 1, 2009; 182(5): 2786 - 2794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kovar, J. Tomala, H. Chmelova, L. Kovar, T. Mrkvan, R. Joskova, Z. Zakostelska, T. Etrych, J. Strohalm, K. Ulbrich, et al. Overcoming Immunoescape Mechanisms of BCL1 Leukemia and Induction of CD8+ T-Cell-Mediated BCL1-Specific Resistance in Mice Cured by Targeted Polymer-Bound Doxorubicin Cancer Res., December 1, 2008; 68(23): 9875 - 9883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-M. Kim, N. Sharma, and J. K. Nyborg The Proto-Oncogene Bcl3, Induced by Tax, Represses Tax-Mediated Transcription via p300 Displacement from the Human T-Cell Leukemia Virus Type 1 Promoter J. Virol., December 1, 2008; 82(23): 11939 - 11947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Pakpour, C. Zaph, and P. Scott The Central Memory CD4+ T Cell Population Generated during Leishmania major Infection Requires IL-12 to Produce IFN-{gamma} J. Immunol., June 15, 2008; 180(12): 8299 - 8305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zheng, P. A. Cohen, C. A. Paustian, T. D. Johnson, W. T. Lee, S. Shu, and G. K. Koski Paired Toll-like Receptor Agonists Enhance Vaccine Therapy through Induction of Interleukin-12 Cancer Res., June 1, 2008; 68(11): 4045 - 4049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Joshi and S. M. Kaech Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation J. Immunol., February 1, 2008; 180(3): 1309 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-B. Lee, K.-A Lee, and J. Chang Phenotypic changes induced by IL-12 priming regulate effector and memory CD8 T cell differentiation Int. Immunol., September 6, 2007; (2007) dxm072v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Curtsinger, M. Y. Gerner, D. C. Lins, and M. F. Mescher Signal 3 Availability Limits the CD8 T Cell Response to a Solid Tumor J. Immunol., June 1, 2007; 178(11): 6752 - 6760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Li, H. Yamada, T. Yajima, R. Nakagawa, K. Shimoda, K. Nakayama, and Y. Yoshikai Tyk2 Signaling in Host Environment Plays an Important Role in Contraction of Antigen-Specific CD8+ T Cells following a Microbial Infection J. Immunol., April 1, 2007; 178(7): 4482 - 4488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Li, C. Eppolito, K. Odunsi, and P. A. Shrikant IL-12-Programmed Long-Term CD8+ T Cell Responses Require STAT4 J. Immunol., December 1, 2006; 177(11): 7618 - 7625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Chilton and T. C. Mitchell CD8 T Cells Require Bcl-3 for Maximal Gamma Interferon Production upon Secondary Exposure to Antigen Infect. Immun., July 1, 2006; 74(7): 4180 - 4189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Havenar-Daughton, G. A. Kolumam, and K. Murali-Krishna Cutting Edge: The Direct Action of Type I IFN on CD4 T Cells Is Critical for Sustaining Clonal Expansion in Response to a Viral but Not a Bacterial Infection J. Immunol., March 15, 2006; 176(6): 3315 - 3319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zakharova and H. K. Ziegler Paradoxical Anti-Inflammatory Actions of TNF-{alpha}: Inhibition of IL-12 and IL-23 via TNF Receptor 1 in Macrophages and Dendritic Cells J. Immunol., October 15, 2005; 175(8): 5024 - 5033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Curtsinger, D. C. Lins, C. M. Johnson, and M. F. Mescher Signal 3 Tolerant CD8 T Cells Degranulate in Response to Antigen but Lack Granzyme B to Mediate Cytolysis J. Immunol., October 1, 2005; 175(7): 4392 - 4399. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
