| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
BRIEF REVIEWS |
Departments of
*
Internal Medicine (Division of Pulmonary and Critical Care Medicine) and
Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109
Leukotrienes are bronchoconstrictor and vasoactive lipid mediators that are targets in the treatment of asthma. Although they are increasingly recognized to exert broad proinflammatory effects, their role in innate immune responses is less well appreciated. These molecules are indeed synthesized by resident and recruited leukocytes during infection. Acting via cell surface G protein-coupled receptors and subsequent intracellular signaling events, they enhance leukocyte accumulation, phagocyte capacity for microbial ingestion and killing, and generation of other proinflammatory mediators. Interestingly, a variety of acquired states of immunodeficiency, such as HIV infection and malnutrition, are characterized by a relative deficiency of leukotriene synthesis. The data reviewed herein point to leukotrienes as underappreciated yet highly relevant mediators of innate immunity.
This article has been cited by other articles:
|
|
 |
|
  L. L. N. Hubbard, M. N. Ballinger, P. E. Thomas, C. A. Wilke, T. J. Standiford, K. S. Kobayashi, R. A. Flavell, and B. B. Moore A Role for IL-1 Receptor-Associated Kinase-M in Prostaglandin E2-Induced Immunosuppression Post-Bone Marrow Transplantation J. Immunol., June 1, 2010; 184(11): 6299 - 6308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mancuso, C. Lewis, C. H. Serezani, D. Goel, and M. Peters-Golden Intrapulmonary Administration of Leukotriene B4 Enhances Pulmonary Host Defense against Pneumococcal Pneumonia Infect. Immun., May 1, 2010; 78(5): 2264 - 2271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Meliton, N. M. Munoz, C. M. Osan, L. N. Meliton, and A. R. Leff Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes Eur. Respir. J., February 1, 2010; 35(2): 402 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. d. S. Costa, R. de Souza-Martins, M. C. de Souza, C. F. Benjamim, B. Piva, B. L. Diaz, M. Peters-Golden, M. d. G. Henriques, C. Canetti, and C. Penido Leukotriene B4 mediates {gamma}{delta} T lymphocyte migration in response to diverse stimuli J. Leukoc. Biol., February 1, 2010; 87(2): 323 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. H. Serezani, D. M. Aronoff, R. G. Sitrin, and M. Peters-Golden Fc{gamma}RI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions Blood, October 8, 2009; 114(15): 3316 - 3324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Balestrieri, A. Maekawa, W. Xing, M. H. Gelb, H. R. Katz, and J. P. Arm Group V Secretory Phospholipase A2 Modulates Phagosome Maturation and Regulates the Innate Immune Response against Candida albicans J. Immunol., April 15, 2009; 182(8): 4891 - 4898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Lee, C. H. Serezani, A. I. Medeiros, M. N. Ballinger, and M. Peters-Golden Crosstalk between Prostaglandin E2 and Leukotriene B4 Regulates Phagocytosis in Alveolar Macrophages via Combinatorial Effects on Cyclic AMP J. Immunol., January 1, 2009; 182(1): 530 - 537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Medeiros, A. Sa-Nunes, W. M. Turato, A. Secatto, F. G. Frantz, C. A. Sorgi, C. H. Serezani, G. S. Deepe Jr., and L. H. Faccioli Leukotrienes Are Potent Adjuvant during Fungal Infection: Effects on Memory T Cells J. Immunol., December 15, 2008; 181(12): 8544 - 8551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Uozumi, Y. Kita, and T. Shimizu Modulation of Lipid and Protein Mediators of Inflammation by Cytosolic Phospholipase A2{alpha} during Experimental Sepsis J. Immunol., September 1, 2008; 181(5): 3558 - 3566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Ballinger, L. L. N. Hubbard, T. R. McMillan, G. B. Toews, M. Peters-Golden, R. Paine III, and B. B. Moore Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L114 - L122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kalsotra, L. Du, Y. Wang, P. A. Ladd, Y. Kikuta, M. Duvic, A. S. Boyd, D. S. Keeney, and H. W. Strobel Inflammation resolved by retinoid X receptor-mediated inactivation of leukotriene signaling pathways FASEB J, February 1, 2008; 22(2): 538 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Coffey, C. H. Serezani, S. M. Phare, N. Flamand, and M. Peters-Golden NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis J. Leukoc. Biol., December 1, 2007; 82(6): 1585 - 1591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Haworth and B. D. Levy Endogenous lipid mediators in the resolution of airway inflammation Eur. Respir. J., November 1, 2007; 30(5): 980 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wada, C. J. DeLong, Y. H. Hong, C. J. Rieke, I. Song, R. S. Sidhu, C. Yuan, M. Warnock, A. H. Schmaier, C. Yokoyama, et al. Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic Acid-derived Substrates and Products J. Biol. Chem., August 3, 2007; 282(31): 22254 - 22266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Woszczek, L.-Y. Chen, S. Nagineni, S. Alsaaty, A. Harry, C. Logun, R. Pawliczak, and J. H. Shelhamer IFN-{gamma} Induces Cysteinyl Leukotriene Receptor 2 Expression and Enhances the Responsiveness of Human Endothelial Cells to Cysteinyl Leukotrienes J. Immunol., April 15, 2007; 178(8): 5262 - 5270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Valera, A. G. Vigo, S. Alonso, L. Barbolla, M. S. Crespo, and N. Fernandez Peptidoglycan and mannose-based molecular patterns trigger the arachidonic acid cascade in human polymorphonuclear leukocytes J. Leukoc. Biol., April 1, 2007; 81(4): 925 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Serio, C. Luo, L. Luo, and J. T. Mao TNF-{alpha} downregulates the leukotriene C4 synthase gene in mononuclear phagocytes Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L215 - L222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Ballinger, D. M. Aronoff, T. R. McMillan, K. R. Cooke, K. Olkiewicz, G. B. Toews, M. Peters-Golden, and B. B. Moore Critical Role of Prostaglandin E2 Overproduction in Impaired Pulmonary Host Response following Bone Marrow Transplantation J. Immunol., October 15, 2006; 177(8): 5499 - 5508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Serezani, J. H. Perrela, M. Russo, M. Peters-Golden, and S. Jancar Leukotrienes Are Essential for the Control of Leishmania amazonensis Infection and Contribute to Strain Variation in Susceptibility. J. Immunol., September 1, 2006; 177(5): 3201 - 3208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Ballinger, R. Paine III, C. H. C. Serezani, D. M. Aronoff, E. S. Choi, T. J. Standiford, G. B. Toews, and B. B. Moore Role of Granulocyte Macrophage Colony-Stimulating Factor during Gram-Negative Lung Infection with Pseudomonas aeruginosa Am. J. Respir. Cell Mol. Biol., June 1, 2006; 34(6): 766 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Wieland, S. Florquin, J. M. Pater, S. Weijer, and T. van der Poll CD4+ Cells Play a Limited Role in Murine Lung Infection with Mycobacterium kansasii Am. J. Respir. Cell Mol. Biol., February 1, 2006; 34(2): 167 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mancuso, G. B. Huffnagle, M. A. Olszewski, J. Phipps, and M. Peters-Golden Leptin Corrects Host Defense Defects after Acute Starvation in Murine Pneumococcal Pneumonia Am. J. Respir. Crit. Care Med., January 15, 2006; 173(2): 212 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Carey, J. A. Bradbury, J. M. Seubert, R. Langenbach, D. C. Zeldin, and D. R. Germolec Contrasting Effects of Cyclooxygenase-1 (COX-1) and COX-2 Deficiency on the Host Response to Influenza A Viral Infection J. Immunol., November 15, 2005; 175(10): 6878 - 6884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Woszczek, R. Pawliczak, H.-Y. Qi, S. Nagineni, S. Alsaaty, C. Logun, and J. H. Shelhamer Functional Characterization of Human Cysteinyl Leukotriene 1 Receptor Gene Structure J. Immunol., October 15, 2005; 175(8): 5152 - 5159. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
