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The Journal of Immunology, 2005, 174: 8011-8016.
Copyright © 2005 by The American Association of Immunologists

Phosphatidylinositol-Specific Phospholipase C of Bacillus anthracis Down-Modulates the Immune Response1

Lauren A. Zenewicz, Zhengyu Wei, Howard Goldfine and Hao Shen2

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104

Phosphatidylinositol-specific phospholipases (PI-PLCs) are virulence factors produced by many pathogenic bacteria, including Bacillus anthracis and Listeria monocytogenes. Bacillus PI-PLC differs from Listeria PI-PLC in that it has strong activity for cleaving GPI-anchored proteins. Treatment of murine DCs with Bacillus, but not Listeria, PI-PLC inhibited dendritic cell (DC) activation by TLR ligands. Infection of mice with Listeria expressing B. anthracis PI-PLC resulted in a reduced Ag-specific CD4 T cell response. These data indicate that B. anthracis PI-PLC down-modulates DC function and T cell responses, possibly by cleaving GPI-anchored proteins important for TLR-mediated DC activation.




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