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The Journal of Immunology, 2005, 174: 7492-7495.
Copyright © 2005 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Egress of Newly Generated Plasma Cells from Peripheral Lymph Nodes Depends on {beta}2 Integrin1

Oliver Pabst*, Thorsten Peters{dagger}, Niklas Czeloth*, Günter Bernhardt*, Karin Scharffetter-Kochanek{dagger} and Reinhold Förster2,*

* Institute of Immunology, Hannover Medical School, Hannover, Germany; and {dagger} Department of Dermatology and Allergology, University of Ulm, Ulm, Germany

During humoral immune responses, naive B cells differentiate into Ab-secreting plasma cells within secondary lymphoid organs. Differentiating plasma cells egress from their sites of generation and redistribute to other tissues, predominantly the bone marrow and mucosal tissues. In this study, we demonstrate that within peripheral lymph nodes newly generated plasma cells localize to medullary cords which express the {beta}2 integrin ligand ICAM-1. In {beta}2 integrin-deficient mice plasma cells accumulate inside the lymph nodes, resulting in severely reduced plasma cell numbers in the bone marrow. Since plasma cells isolated from {beta}2 integrin-deficient animals migrate efficiently into the bone marrow when transferred i.v., our findings provide profound evidence that {beta}2 integrins are required for the egress of plasma cells from peripheral lymph nodes.




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